Wind-tunnel investigation of basic aerodynamic characteristics of a supercritical-wing research airplane configuration

Transonic pressure tunnel and transonic tunnel tests were performed to determine the aerodynamic characteristics of a 0.087 scale model of a supercritical wing research airplane configuration at Mach numbers from 0.25 to 1.30. The investigation included tests to determine the basic longitudinal aerodynamic characteristics, the lateral-directional aerodynamic characteristics for sideslip angles of 0 deg and + or - 2.5 deg, and the effects of Reynolds number and aeroelasticity

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer

<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression. <b>PATIENTS AND METHODS</b>: Angiogenesis was assessed in 105 patients with either prostate cancer (79) or benign prostatic hyperplasia (BPH, 26) and these data correlated with levels of COX-2 expression in the same dataset. The mean microvessel density (MVD) was analysed as a marker of angiogenesis, using the endothelial antigen CD34 stained by immunohistochemistry. <b>RESULTS</b>: There was no difference in MVD in progressive tumour stages compared with BPH. There was a negative correlation between MVD and COX-2 expression, but the effect of increased COX-2 expression on MVD was not marked. <b>CONCLUSION</b>: These data suggest that COX-2 drives tumour spread in prostate cancer by means other than the promotion of angiogenesis

Convergence improvement for coupled cluster calculations

Convergence problems in coupled-cluster iterations are discussed, and a new iteration scheme is proposed. Whereas the Jacobi method inverts only the diagonal part of the large matrix of equation coefficients, we invert a matrix which also includes a relatively small number of off-diagonal coefficients, selected according to the excitation amplitudes undergoing the largest change in the coupled cluster iteration. A test case shows that the new IPM (inversion of partial matrix) method gives much better convergence than the straightforward Jacobi-type scheme or such well-known convergence aids as the reduced linear equations or direct inversion in iterative subspace methods.Comment: 7 pages, IOPP styl

A New Local Temperature Distribution Function for X-ray Clusters: Cosmological Applications

(abridged) We present a new determination of the local temperature function of X-ray clusters. We use a new sample comprising fifty clusters for which temperature information is now available, making it the largest complete sample of its kind. It is therefore expected to significantly improve the estimation of the temperature distribution function of moderately hot clusters. We find that the resulting temperature function is higher than previous estimations, but agrees well with the temperature distribution function inferred from the BCS and RASS luminosity function. We have used this sample to constrain the amplitude of the matter fluctuations on cluster's scale of $8\sqrt[3]{\Omega_0}^{-1}h^{-1}$Mpc, assuming a mass-temperature relation based on recent numerical simulations. We find $\sigma_8 = 0.6\pm 0.02$ for an $\Omega_0 = 1$ model. Our sample provides an ideal reference at $z \sim 0$ to use in the application of the cosmological test based on the evolution of X-ray cluster abundance (Oukbir & Blanchard 1992, 1997). Using Henry's sample, we find that the abundance of clusters at $z = 0.33$ is significantly smaller, by a factor larger than 2, which shows that the EMSS sample provides strong evidence for evolution of the cluster abundance. A likelihood analysis leads to a rather high value of the mean density parameter of the universe: $\Omega =0.92 \pm 0.22$ (open case) and $\Omega =0.86 \pm 0.25$ (flat case), which is consistent with a previous, independent estimation based on the full EMSS sample by Sadat et al.(1998). Some systematic uncertainties which could alter this result are briefly discussed.Comment: 31 pages, 12 figures, mathches the version published in Astronomy and Astrophysic

An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients

Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters. In contrast an increase in N-Ras membrane expression in the transition from hormone sensitive to hormone refractory prostate cancer was associated with shorter time to relapse (p=0.01) and shorter disease specific survival (p=0.008). In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse (p=0.02) and expression correlated with phosphorylated MAP kinase (p=0.010) and proliferation index (Ki67, p=0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade

Drive mechanism for production of simulated human breath

Simulated breath drive mechanism was developed as subsystem to breathing metabolic simulator. Mechanism reproduces complete range of human breath rate, breath depth, and breath waveform, as well as independently controlled functional residual capacity. Mechanism was found capable of simulating various individual human breathing characteristics without any changes of parts

Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer

Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer. Patients and methods Twenty patients with prostate cancer resistant to androgen-deprivation therapy were selected for study. The records of patients with tumours before and after antiandrogen therapy, and with a full clinical follow-up, were retrieved. AR gene amplification and X chromosome copy number were assessed by fluorescence in situ hybridization using a labelled probe at locus Xq11-13 for the AR gene and a labelled a-satellite probe for the X chromosome. At least 20 nuclei were scored over three tumour areas by two independent observers. Results Aneusomy of the X chromosome was reported respectively in seven (35%) and 11 (55%) tumours before and after hormone relapse, the AR gene copy number was increased in seven (35%) and 13 (65%), respectively, and AR gene amplification was detected in one (5%) and three (15%), respectively. Neither increased AR copy number nor AR amplification in primary tumours precluded a biological response to androgen-deprivation therapy. Conclusion The rate of AR gene amplification is too low to be solely responsible for the development of antiandrogen-resistant prostate cancer. Also, the presence of amplified AR and cells aneusomic for the X chromosome in primary tumours that respond to androgen-deprivation therapy suggests that an increase in AR gene copy number does not prevent a tumour from responding to this therapy. Therefore other mechanisms which could cause hormone-refractory prostate cancer must be investigated before it is understood why so many patients relapse with this disease

Particle-particle and quasiparticle random phase approximations: Connections to coupled cluster theory

We establish a formal connection between the particle-particle (pp) random phase approximation (RPA) and the ladder channel of the coupled cluster doubles (CCD) equations. The relationship between RPA and CCD is best understood within a Bogoliubov quasiparticle (qp) RPA formalism. This work is a follow-up to our previous formal proof on the connection between particle-hole (ph) RPA and ring-CCD. Whereas RPA is a quasibosonic approximation, CC theory is a correct bosonization in the sense that the wavefunction and Hilbert space are exactly fermionic. Coupled cluster theory achieves this goal by interacting the ph (ring) and pp (ladder) diagrams via a third channel that we here call "crossed-ring" whose presence allows for full fermionic antisymmetry. Additionally, coupled cluster incorporates what we call "mosaic" terms which can be absorbed into defining a new effective one-body Hamiltonian. The inclusion of these mosaic terms seems to be quite important. The pp-RPA an d qp-RPA equations are textbook material in nuclear structure physics but are largely unknown in quantum chemistry, where particle number fluctuations and Bogoliubov determinants are rarely used. We believe that the ideas and connections discussed in this paper may help design improved ways of incorporating RPA correlation into density functionals based on a CC perspective