64 research outputs found

    Successful treatment of idiopathic cold urticaria with the association of H1 and H2 antagonists: a case report

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    We report here the case of a patient suffering from idiopathic cold urticaria who did not respond to H1 antihistamine but who responded dramatically to the combination of H1 and H2 antagonists. Under H1 treatment, the urticaria was florid and the ice cube test clearly positive. After the addition of an H2 antihistamine, all the symptoms disappeared and the ice cube test became negative. The different therapeutic schedules proposed thereafter, showed that only the combination therapy was effective H1 antihistamine alone or H2 antihistamine alone being unable to modify the course of the disease

    Rendement diagnostique et utilite d'une unite d'investigation: etude prospective. [Diagnostic performance and usefulness of a research unit: prospective study]

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    An attempt was made to compare the diagnostic efficiency and overall usefulness (for the patient and for his primary care physician) of an investigation unit in internal medicine. 100 patients seen successively were studied. At the end of the investigation the patients were divided into 3 groups: (A) organic disease diagnosed (n = 44); (B) unexplained somatic complaint (n = 16); (C) unexplained functional complaint (n = 40). One year later, an inquiry about the patient's outcome was made by telephone to the patient and/or his physician. Follow-up of 99 patients did not disclose diagnostic errors in patients of groups A and C; in group B, 2 diagnoses were missed. The investigation was considered "useful" in 31 patients (disease cured or improved, patient reassured); 57% of primary-care physicians were aided despite a negative investigation

    Frequence des allergenes respiratoires impliques dans la rhinite et l'asthme bronchique de l'adulte. Etude prospective. [Frequency of respiratory allergens involved in rhinitis and bronchial asthma in adults. Prospective study]

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    In a prospective study of 100 adults, we determined the frequency of hypersensitivity to allergens most often diagnosed in patients suffering from rhinitis and bronchial asthma. Skin-prick tests and RAST for 15 allergens were performed in all patients. The most frequent allergen detected by skin-prick test was the extract "total house dust" (50%) but the corresponding RAST was rarely positive (16%); then came grass pollens (46%), house dust mites (D. pteronyssinus, 38%) and animal danders (cat 33%). On the other hand, a positive skin test with the two moulds chosen was rare (Alternaria tenuis 5%, Cladosporium herbarum 4%). For all the allergens investigated, the correlation between positive skin test and positive RAST was proportional to the intensity of the skin reaction (94% for the skin tests +, 40% for the skin tests ++). 35% of the patients with at least a positive skin test and a RAST for one of the allergens tested had in fact a total IgE concentration not suggestive of atopy (less than 100 kU/1). The results indicate that, with the exception of the 2 moulds chosen, the frequency of allergens diagnosed in Switzerland is very similar to what has been found in other countries with different climates

    Effect of foodstuffs on the absorption of zinc sulfate

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    Single doses of zinc sulfate were given to healthy young volunteers, either in the fasting state or with various types of meals. Dairy products (milk and cheese) and brown bread decreased zinc absorption, as indicated by a significant drop in peak serum zinc levels. Zinc absorption was decreased when zinc was given in the fasting state with the same amounts of purified phosphate or phytate as those found in foods above. Experiments in vitro have shown that zinc is precipitated by phosphate and phytate at pH values close to that of the intestinal lumen. Coffee also seems to inhibit zinc absorption
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