39 research outputs found

    Mitochondrial BK Ca

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    A knowledge-based system for spinning management

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    This paper describes the development of a knowledge-based system to support and improve the spinning process. It is divided in three parts. The first part describes a statistical study using sixteen raw cottons and three kinds of yarn. A set of mathematical models describes the relationships between cotton fiber and yarn properties. Eighteen different models have been identified according to different control processes (HVI motion control and Spinlab and individual instruments) and different production processes (ring and rotor spinning, OE RU 14 Spincomat and Autocoro 117). The second part details the implementation of the knowledge-based system using the programming languages PROLOG and C. The knowledge base uses a framework shell (flex or forward logical expert systems) that interfaces with PROLOG. This prototype can be used either to predict the characteristics of the yarn according to those of the available raw materials, or to select the raw materials adequate to produce yarn with specific characteristics. The last section presents some conclusions of the work

    Evidence of necroptosis in hearts subjected to various forms of ischemic insults

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    Long-lasting ischemia can result in cell loss; however, repeated episodes of brief ischemia increase the resistance of the heart against deleterious effects of subsequent prolonged ischemic insult and promote cell survival. Traditionally, it is believed that the supply of blood to the ischemic heart is associated with release of cytokines, activation of inflammatory response and induction of necrotic cell death. In the past few years, this paradigm of passive necrosis as an uncontrolled cell death has been re-examined and the existence of a strictly regulated form of necrotic cell death, necroptosis, has been documented. This controlled cell death modality, resembling all morphological features of necrosis, has been investigated in different types of ischemia-associated heart injuries. The process of necroptosis has been found to be dependent on the activation of RIP1-RIP3-MLKL axis, which induces changes leading to the rupture of cell membrane. This pathway is activated by TNF-Îą, which has also been implicated in the cardioprotective signaling pathway of ischemic preconditioning. Thus, this review is intended to describe the TNF-Îą mediated signaling leading to either cell survival or necroptotic cell death. In addition, some experimental data suggesting a link between heart dysfunction and the cellular loss due to necroptosis are discussed in various conditions of myocardial ischemia.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
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