Comparison of Leptin Blood Levels and Correlation of Leptin with LH and FSH in PCOS Patients and Normal Individuals

Introduction: There are high concentrations of LH in Polycystic Ovary syndrome (PCOS) patients. These patients are usually obese and have increased leptin levels in their blood. It is not clear whether obesity or increased leptin levels cause changes in the hypothalamus- pituitary axis. This study evaluated the blood leptin, LH and FSH levels in PCOS group and compared them with a control group. Methods: The study included 27 PCOS patients and 27 normal individuals as control. They were matched for age (18-40 year). A fasting blood sample was taken and then freezed at -80 degrees Celsius. This sample was used for measurement of leptin, FSH, LH and insulin levels. Results: There was a significant difference between leptin, insulin and glucose levels in the two groups (P25 as compared to group with BMI<25 (P<0.05). The mean LH level in PCOS group was significantly higher than the control group. Conclusion: It is possible that in PCOS patients, high levels of LH could be related to an increase in leptin levels along with insulin resistance

Study of Blood Leptin Levels before and After Treatment with Metformin in Diabetes Type Ii Patients

Introduction: Leptin is a fat tissue hormone that has 176 amino acids with a molecular weight of 16 KD . Leptin has effects on the hypothalamus and peripheral tissues resulting in decreased food absorption and increased energy consumption that finally reduces the body weight and BMI. The aim of this research was to investigate the blood levels of leptin before and after treatment with Metformin in type II diabetic patients. Methods: 25 type II diabetic patients without any previous drug treatment history were investigated. This study was a clinical trail before and after treatment with Metformin. Results: There was no particular difference in BMI, average body weight, fat mass and free fat mass before and after treatment. Similarly, the difference in concentration levels of blood glucose, cholesterol, tri-glycerides and LDL-cholesterol before and after treatment was not statistically significant. Also, there was no difference in the average concentration of leptin and insulin before and after treatment Conclusion: This result showed that although metformin decreased glucose and lipid levels during the treatment period, (1 month) it did not have an effect on leptin, Insulin and other related factors during treatment.