Sirtuins, bioageing, and cancer

The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins are heavily implicated in cell cycle, cell division, transcription regulation, and metabolism, which places the various family members at critical junctures in cellular metabolism. Typically, Sirtuins have been implicated in the preservation of genomic stability and in the prolongation of lifespan though many of their target interactions remain unknown. Sirtuins play key roles in tumourigenesis, as some have tumour-suppressor functions and others influence tumours through their control of the metabolic state of the cell. Their links to ageing have also highlighted involvement in various age-related and degenerative diseases. Here, we discuss the current understanding of the role of Sirtuins in age-related diseases while taking a closer look at their roles and functions in maintaining genomic stability and their influence on telomerase and telomere function

On the nature of the torus in the complex Lorenz equations.

The complex Lorenz equations are a nonlinear fifth-order set of physically derived differential equations which exhibit an exact analytic limit cycle which subsequently bifurcates to a torus. In this paper we build upon previously derived results to examine a connection between this torus at high and low r1 bifurcation parameter) and between zero and nonzero r2(complexity parameter); in so doing, we are able to gain insight on the effect of the rotational invariance of the system, and on how extra weak dispersion (r2 ≠ 0) affects the chaotic behavior of the real Lorenz system (which describes a weakly dissipative, dispersive instability)

A delay recruitment model of the cardiovascular control system.

Copyright will be owned by Springer. We develop a nonlinear delay-differential equation for the human cardiovascular control system, and use it to explore blood pressure and heart rate variability under short-term baroreflex control. The model incorporates an intrinsically stable heart rate in the absence of nervous control, and features baroreflex influence on both heart rate and peripheral resistance. Analytical simplifications of the model allow a general investigation of the rôles played by gain and delay, and the effects of ageing.

Labour Market Mismatch Among UK Graduates: An Analysis Using REFLEX Data

There is much disagreement in the literature over the extent to which graduates are mismatched in the labour market and the reasons for this. In this paper we utilise the Flexible Professional in the Knowledge Society (REFLEX) data set to cast light on these issues, based on data for UK graduates. REFLEX examines the labour market status of graduates five years after graduation and distinguishes between first and current job, vertical and horizontal mismatch, over/underqualification and over/underskilling as well as including a range of questions on the nature of work organisation and individual competences. We find substantial pay penalties for over-education for both sexes and for overskilling in the case of men only. When both education and skill mismatch variables are included together in the model only overskilling reduces job satisfaction consistently for both sexes. Using job attributes data it appears that the lower wages of the overqualified may in part simply represent a compensating wage differential for positive job attributes, while for men at least there are real costs to being overskilled.skills, education, job matching, graduates

What Can Active Labour Market Policies Do?

Ireland faces a crisis of mass unemployment. More than 14 per cent of the labour force is unemployed, and long-term unemployment is growing rapidly. Active labour market policies (ALMPs) - consisting of a range of assistance, training and employment programmes to support the unemployed back to work - have been held out as an essential part of the policy response to unemployment. This paper examines a wide range of national and international research on the effectiveness of ALMPs to ask: i) what do ALMPs do for the unemployed?, ii) are some programmes more effective than others? iii) what can we expect ALMPs to achieve in a recession? The paper shows that while research on the impact of active labour market programmes is far from conclusive and faces a number of difficult methodological challenges, it does provide a basis on which to identify the types of programmes that have been found to enhance the employment prospects of their unemployed clients.labour market/Policy