A 300 GHz "Always-in-Focus" Focusing System for Target Detection

A focusing system for a 300 GHz radar with 5 m target distance and 10 mm diameter spot size resolution is proposed. The focusing system is based on a Gaussian telescope scheme and its main parameters have been de¬signed using Gaussian beam quasi-optical propagation theory with an in-house developed MATLAB® based analysis tool. Then, this approach has been applied to a real focusing system based on two elliptical mirrors in order to reduce the distortion and cross-polar level and a plane mirror to provide scanning capabilities. The over¬all system has been simulated with a full-wave electromag¬netic simulator and its behavior is presented. With this approach, the focusing system always works "in-focus" since the only mirror that is rotated when scanning is the output plane mirror, so the beam is almost not distorted. The design process, although based in the well-known Gaussian beam quasi-optical propagation theory, provides a fast and accurate method and minimizes the overall size of the mirrors. As a consequence, the size of the focusing system is also reduced

Evolution of small-scale magnetic elements in the vicinity of granular-size swirl convective motions

Advances in solar instrumentation have led to a widespread usage of time series to study the dynamics of solar features, specially at small spatial scales and at very fast cadences. Physical processes at such scales are determinant as building blocks for many others occurring from the lower to the upper layers of the solar atmosphere and beyond, ultimately for understanding the bigger picture of solar activity. Ground-based (SST) and space-borne (Hinode) high-resolution solar data are analyzed in a quiet Sun region displaying negative polarity small-scale magnetic concentrations and a cluster of bright points observed in G-band and Ca II H images. The studied region is characterized by the presence of two small-scale convective vortex-type plasma motions, one of which appears to be affecting the dynamics of both, magnetic features and bright points in its vicinity and therefore the main target of our investigations. We followed the evolution of bright points, intensity variations at different atmospheric heights and magnetic evolution for a set of interesting selected regions. A description of the evolution of the photospheric plasma motions in the region nearby the convective vortex is shown, as well as some plausible cases for convective collapse detected in Stokes profiles.Comment: 9 figure

Manejo de plantas daninhas na produção orgânica de frutas.

bitstream/CNPUV/8122/1/cir045.pd

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug

BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses. The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations. METHODOLOGY: We studied the activity of the veterinary drug oxantel pamoate against Trichuris muris, Ancylostoma ceylanicum and Necator americanus in vitro and in vivo. In addition, the dose-effect of oxantel pamoate combined with albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin was studied against T. muris in vitro and additive or synergistic combinations were followed up in vivo. PRINCIPAL FINDINGS: We calculated an ED50 of 4.7 mg/kg for oxantel pamoate against T. muris in mice. Combinations of oxantel pamoate with pyrantel pamoate behaved antagonistically in vitro (combination index (CI) = 2.53). Oxantel pamoate combined with levamisole, albendazole or ivermectin using ratios based on their ED50s revealed antagonistic effects in vivo (CI = 1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI = 0.15) was observed when oxantel pamoate-mebendazole was administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacked activity against Ancylostoma ceylanicum and Necator americanus in vivo. CONCLUSIONSIGNIFICANCE: Our study confirms the excellent trichuricidal properties of oxantel pamoate. Since the drug lacks activity against hookworms it is necessary to combine oxantel pamoate with a partner drug with anti-hookworm properties. Synergistic effects were observed for oxantel pamoate-mebendazole, hence this combination should be studied in more detail. Since, of the standard drugs, albendazole has the highest efficacy against hookworms, additional investigations on the combination effect of oxantel pamoate-albendazole should be launche