Pneumococcal conjugate vaccine given shortly after birth stimulates effective antibody concentrations and primes immunological memory for sustained infant protection.

BACKGROUND: In developing countries, newborn immunization with pneumococcal conjugate vaccines (PCVs) could protect young infants who are at high risk of invasive pneumococcal disease (IPD) but might lead to immune tolerance. METHODS: In a randomized trial, young infants received 7-valent PCV at 6, 10, and 14 weeks (Expanded Programme on Immunization [EPI] group) or 0, 10, and 14 weeks (newborn group). Safety was monitored actively at 2-7 days and then passively. Serum samples obtained at birth and 6, 10, 14, 18, 36, and 37 weeks were assayed by enzyme-linked immunosorbent assay for anticapsular immunoglobulin G concentration and avidity. Infants were boosted with either 7-valent PCV or one-fifth dose of pneumococcal polysaccharide vaccine at 36 weeks. Nasopharyngeal swab samples were obtained at 18 and 36 weeks. RESULTS: Three-hundred neonates and young infants were enrolled. Newborn vaccination was well tolerated. Adverse events occurred equally in each group; none was related to immunization. One infant, immunized at birth, died of unrelated neonatal sepsis. At 18 weeks, protective concentrations (≥0.35 μg/mL) were achieved against each serotype by ≥87% of infants with no significant differences between groups. Geometric mean concentrations were higher in the EPI group for serotypes 4, 9V, 18C, and 19F at 18 weeks and for serotype 4 at 36 weeks. Avidity was greater in the newborn group for serotypes 4, 6B, and 19F at 18 weeks and for serotype 19F at 36 weeks. Booster responses and vaccine-type/nonvaccine-type carriage prevalence did not differ between groups. CONCLUSIONS: PCV was safe, immunogenic, and primed for memory when given at birth. There was no evidence of immune tolerance. Vaccination beginning at birth offers an alternative to control IPD in vulnerable young infants

The Distribution of Redshifts in New Samples of Quasi-stellar Objects

Two new samples of QSOs have been constructed from recent surveys to test the hypothesis that the redshift distribution of bright QSOs is periodic in $\log(1+z)$. The first of these comprises 57 different redshifts among all known close pairs or multiple QSOs, with image separations $\leq$ 10\arcsec, and the second consists of 39 QSOs selected through their X-ray emission and their proximity to bright comparatively nearby active galaxies. The redshift distributions of the samples are found to exhibit distinct peaks with a periodic separation of $\sim 0.089$ in $\log(1+z)$ identical to that claimed in earlier samples but now extended out to higher redshift peaks $z = 2.63, 3.45$ and 4.47, predicted by the formula but never seen before. The periodicity is also seen in a third sample, the 78 QSOs of the 3C and 3CR catalogues. It is present in these three datasets at an overall significance level $10^{-5}$ - $10^{-6}$, and appears not to be explicable by spectroscopic or similar selection effects. Possible interpretations are briefly discussed.Comment: submitted for publication in the Astronomical Journal, 15 figure

Ejection of Matter and Energy from NGC 4258

It has been claimed that the megamaser observations of the nucleus of NGC 4258 show that a massive black hole is present in its center (Miyoshi et al. 1995, Greenhill et al. 1995). We show that the evidence of ejection of gas, radio plasma, and X-ray emitting QSOs from this nucleus all show that the ejection is coming from the center in a curving flow within a cone with angle ~40 degrees, centered at P.A. 100 degrees. This is close to the direction in which the velocities from the megamaser have been measured, so that the evidence taken as a whole suggests that the masering gas also is being ejected in the same direction at velocities +/- 900 km/sec and not rotating about a massive black hole. Thus it does not provide evidence for a black hole in the center. Subject headings: galaxies: nuclei: individual (NGC 4258) -- black holes -- masersComment: 7 pages, 1 Figure, LaTex using epsf.tex, submitted to Ap.J.Letter

Cosmology and Cosmogony in a Cyclic Universe

In this paper we discuss the properties of the quasi-steady state cosmological model (QSSC) developed in 1993 in its role as a cyclic model of the universe driven by a negative energy scalar field. We discuss the origin of such a scalar field in the primary creation process first described by F. Hoyle and J. V. Narlikar forty years ago. It is shown that the creation processes which takes place in the nuclei of galaxies are closely linked to the high energy and explosive phenomena, which are commonly observed in galaxies at all redshifts. The cyclic nature of the universe provides a natural link between the places of origin of the microwave background radiation (arising in hydrogen burning in stars), and the origin of the lightest nuclei (H, D, He$^3$ and He$^4$). It also allows us to relate the large scale cyclic properties of the universe to events taking place in the nuclei of galaxies. Observational evidence shows that ejection of matter and energy from these centers in the form of compact objects, gas and relativistic particles is responsible for the population of quasi-stellar objects (QSOs) and gamma-ray burst sources in the universe. In the later parts of the paper we briefly discuss the major unsolved problems of this integrated cosmological and cosmogonical scheme. These are the understanding of the origin of the intrinsic redshifts, and the periodicities in the redshift distribution of the QSOs.Comment: 51 pages including 1 figur

A deep X-ray observation of NGC 4258 and its surrounding field

We present a deep X-ray observation of the low-luminosity active galactic nucleus in NGC4258 (M106) using ASCA. The soft X-ray spectrum <2keV is dominated by thermal emission from optically-thin plasma with kT~0.5keV. The hard X-ray emission is clearly due to a power-law component with photon index Gamma=1.8 absorbed by a column density of N_H=8x10^22/cm^2. The power-law is readily identified with primary X-ray emission from the AGN central engine. We also clearly detect a narrow iron K-alpha emission line at 6.4keV. No broad component is detected. We suggest that the bulk of this narrow line comes from the accretion disk and, furthermore, that the power-law X-ray source which excites this line emission (which is typically identified with a disk corona) must be at least 100GM/c^2 in extent. This is in stark contrast to many higher-luminosity Seyfert galaxies which display a broad iron line indicating a small 10 GM/c^2 X-ray emitting region. It must be stressed that this study constrains the size of the X-ray emitting corona rather than the presence/absence of a radiatively efficient accretion disk in the innermost regions. If, instead, a substantial fraction of the observed narrow line originates from material not associated with the accretion disk, limits can be placed on the parameter space of possible allowed relativistically broad iron lines. By comparing our data with previous ASCA observations, we find marginal evidence for a change in absorbing column density through to the central engine, and good evidence for a change in the AGN flux.Comment: 11 pages, 9 postscript figures. Accepted for publication in Ap

Hybrid nature of 0846+51W1: a BL Lac object with a narrow line Seyfert 1 nucleus

We have found a NLS1 nucleus in the extensively studied eruptive BL Lac, 0846+51W1, out of a large sample of NLS1 compiled from the spectroscopic dataset of SDSS DR1. Its optical spectrum can be well decomposed into three components, a power law component from the relativistic jet, a stellar component from the host galaxy, and a component from a typical NLS1 nucleus. The emission line properties of 0846+51W1, FWHM(Hbeta) ~ 1710 km s^-1 and [OIII]5007/Hbeta ~ 0.32 when it was in faint state, fulfil the conventional definition of NLS1. Strong FeII emission is detected in the SDSS spectrum, which is also typical of NLS1s. We try to estimate its central black hole mass using various techniques and find that 0846+51W1 is very likely emitting at a few times 10% L_Edd. We speculate that Seyfert-like nuclei, including NLS1s, might be concealed in a significant fraction of BL Lacs but have not been sufficiently explored due to the fact that, by definition, the optical-UV continuum of such kind of objects are often overwhelmed by the synchrotron emission.Comment: ChJAA accepte

Population genetic structure associated with a landscape barrier in the Western Grasswren (Amytornis textilis textilis)

Dispersal patterns can dictate genetic population structure and, ultimately, population resilience, through maintaining gene flow and genetic diversity. However, geographical landforms, such as peninsulas, can impact dispersal patterns and thus be a barrier to gene flow. Here, we use 13 375 genome-wide single-nucleotide polymorphisms (SNPs) to evaluate genetic population structure and infer dispersal patterns of the Western Grasswren Amytornis textilis textilis (WGW, n = 140) in the Shark Bay region of Western Australia. We found high levels of genetic divergence between subpopulations on the mainland (Hamelin) and narrow peninsula (Peron). In addition, we found evidence of further genetic sub-structuring within the Hamelin subpopulation, with individuals collected from the western and eastern regions of a conservation reserve forming separate genetic clusters. Spatial autocorrelation analysis within each subpopulation revealed significant local-scale genetic structure up to 35 km at Hamelin and 20 km at Peron. In addition, there was evidence of male philopatry in both subpopulations. Our results suggest a narrow strip of land may be acting as a geographical barrier in the WGW, limiting dispersal between a peninsula and mainland subpopulation. In addition, heterogeneous habitat within Hamelin may be restricting dispersal at the local scale. Furthermore, there is evidence to suggest that the limited gene flow is asymmetrical, with directional dispersal occurring from the bounded peninsula subpopulation to the mainland. This study highlights the genetic structure existing within and between some of the few remaining WGW subpopulations, and shows a need to place equal importance on conservation efforts to maintain them in the future

Globular Clusters as Candidates for Gravitational Lenses to Explain Quasar-Galaxy Associations

We argue that globular clusters (GCs) are good candidates for gravitational lenses in explaining quasar-galaxy associations. The catalog of associations (Bukhmastova 2001) compiled from the LEDA catalog of galaxies (Paturel 1997) and from the catalog of quasars (Veron-Cetty and Veron 1998) is used. Based on the new catalog containing 8382 pairs, we show that one might expect an increased number of GCs around irregular galaxies of types 9 and 10 from the hypothesis that distant compact sources are gravitationally lensed by GCs in the halos of foreground galaxies. The King model is used to determine the central surface densities of 135 GCs in the Milky Way. The distribution of GCs in central surface density was found to be lognormal.Comment: 22 pages, 4 figure

Modeling Repulsive Gravity with Creation

There is a growing interest in the cosmologists for theories with negative energy scalar fields and creation, in order to model a repulsive gravity. The classical steady state cosmology proposed by Bondi, Gold and Hoyle in 1948, was the first such theory which used a negative kinetic energy creation field to invoke creation of matter. We emphasize that creation plays very crucial role in cosmology and provides a natural explanation to the various explosive phenomena occurring in local (z<0.1) and extra galactic universe. We exemplify this point of view by considering the resurrected version of this theory - the quasi-steady state theory, which tries to relate creation events directly to the large scale dynamics of the universe and supplies more natural explanations of the observed phenomena. Although the theory predicts a decelerating universe at the present era, it explains successfully the recent SNe Ia observations (which require an accelerating universe in the standard cosmology), as we show in this paper by performing a Bayesian analysis of the data.Comment: The paper uses an old SNeIa dataset. With the new improved data, for example the updated gold sample (Riess et al, astro-ph/0611572), the fit improves considerably (\chi^2/DoF=197/180 and a probability of goodness-of-fit=18%

Molecular Gas, Dust and Star Formation in the Barred Spiral NGC 5383

We present multi-wavelength (interferometer and single-dish CO J=1-0, Halpha, broadband optical and near-infrared) observations of the classic barred spiral NGC 5383. We compare the observed central gas and dust morphology to the predictions of recent hydrodynamic simulations. In the nuclear region, our observations reveal three peaks lying along a S-shaped gas and dust distribution. In contrast, the model predicts a circumnuclear ring, not the observed S-shaped distribution; moreover, the predicted surface density contrast between the central gas accumulation and the bar dust lanes is an order of magnitude larger than observed. The discrepancies are not due to unexplored model parameter space or a nuclear bar but are probably due to the vigorous (7 solar masses per year) star formation activity in the center. As is common in similar bars, the star formation rate in the bar between the bar ends and the central region is low (~0.5 solar masses per yr), despite the high gas column density in the bar dust lanes; this is generally attributed to shear and shocks. We note a tendency for the HII regions to be associated with the spurs feeding the main bar dust lanes, but these are located on the leading side of the bar. We propose that stars form in the spurs, which provide a high column density but low shear environment. HII regions can therefore be found even on the leading side of the bar because the ionizing stars pass ballistically through the dust laneComment: Accepted for publication in The Astrophysical Journal, 33 pages (includes 10 figures