Benefit of visual speech information for word comprehension in post-stroke aphasia

Aphasia is a language disorder that often involves speech comprehension impairments affecting communication. In face-to-face settings, speech is accompanied by mouth and facial movements, but little is known about the extent to which they benefit aphasic comprehension. This study investigated the benefit of visual information accompanying speech for word comprehension in people with aphasia (PWA) and the neuroanatomic substrates of any benefit. Thirty-six PWA and 13 neurotypical matched control participants performed a picture-word verification task in which they indicated whether a picture of an animate/inanimate object matched a subsequent word produced by an actress in a video. Stimuli were either audiovisual (with visible mouth and facial movements) or auditory-only (still picture of a silhouette) with audio being clear (unedited) or degraded (6-band noise-vocoding). We found that visual speech information was more beneficial for neurotypical participants than PWA, and more beneficial for both groups when speech was degraded. A multivariate lesion-symptom mapping analysis for the degraded speech condition showed that lesions to superior temporal gyrus, underlying insula, primary and secondary somatosensory cortices, and inferior frontal gyrus were associated with reduced benefit of audiovisual compared to auditory-only speech, suggesting that the integrity of these fronto-temporo-parietal regions may facilitate cross-modal mapping. These findings provide initial insights into our understanding of the impact of audiovisual information on comprehension in aphasia and the brain regions mediating any benefit

Benefit of Visual Speech Information for Word Comprehension in Post-stroke Aphasia

Aphasia is a language disorder that often involves speech comprehension impairments affecting communication. In face-to-face settings, speech is accompanied by mouth and facial movements, but little is known about the extent to which they benefit aphasic comprehension. This study investigated the benefit of visual information accompanying speech for word comprehension in people with aphasia (PWA) and the neuroanatomic substrates of any benefit. Thirty-six PWA and 13 neurotypical matched control participants performed a picture-word verification task in which they indicated whether a picture of an animate/inanimate object matched a subsequent word produced by an actress in a video. Stimuli were either audiovisual (with visible mouth and facial movements) or auditory-only (still picture of a silhouette) with audio being clear (unedited) or degraded (6-band noise-vocoding). We found that visual speech information was more beneficial for neurotypical participants than PWA, and more beneficial for both groups when speech was degraded. A multivariate lesion-symptom mapping analysis for the degraded speech condition showed that lesions to superior temporal gyrus, underlying insula, primary and secondary somatosensory cortices, and inferior frontal gyrus were associated with reduced benefit of audiovisual compared to auditory-only speech, suggesting that the integrity of these fronto-temporo-parietal regions may facilitate cross-modal mapping. These findings provide initial insights into our understanding of the impact of audiovisual information on comprehension in aphasia and the brain regions mediating any benefit

Line Graphs of Weighted Networks for Overlapping Communities

In this paper, we develop the idea to partition the edges of a weighted graph in order to uncover overlapping communities of its nodes. Our approach is based on the construction of different types of weighted line graphs, i.e. graphs whose nodes are the links of the original graph, that encapsulate differently the relations between the edges. Weighted line graphs are argued to provide an alternative, valuable representation of the system's topology, and are shown to have important applications in community detection, as the usual node partition of a line graph naturally leads to an edge partition of the original graph. This identification allows us to use traditional partitioning methods in order to address the long-standing problem of the detection of overlapping communities. We apply it to the analysis of different social and geographical networks.Comment: 8 Pages. New title and text revisions to emphasise differences from earlier paper

Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging

Objective: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain structure and therapy response. Methods: A cross-over randomised repeated measures trial with five testing time points (12-week intervals), conducted at the university or participants' homes, captured baseline (T1), therapy (T2-T4) and maintenance (T5) effects. Participants with chronic poststroke aphasia and spoken language comprehension impairments completed consecutive Listen-In and standard care blocks (both 12 weeks with order randomised). Repeated measures analyses of variance compared change in spoken language comprehension on two co-primary outcomes over therapy versus standard care. Three structural MRI scans (T2-T4) for each participant (subgroup, n=25) were analysed using cross-sectional and longitudinal voxel-based morphometry. Results: Thirty-five participants completed, on average, 85 hours (IQR=70–100) of Listen-In (therapy first, n=18). The first study-specific co-primary outcome (Auditory Comprehension Test (ACT)) showed large and significant improvements for trained spoken words over therapy versus standard care (11%, Cohen’s d=1.12). Gains were largely maintained at 12 and 24 weeks. There were no therapy effects on the second standardised co-primary outcome (Comprehensive Aphasia Test: Spoken Words and Sentences). Change on ACT trained words was associated with volume of pretherapy right hemisphere white matter and post-therapy grey matter tissue density changes in bilateral temporal lobes. Conclusions: Individuals with chronic aphasia can improve their spoken word comprehension many years after stroke. Results contribute to hemispheric debates implicating the right hemisphere in therapy-driven language recovery. Listen-In will soon be available on GooglePlay. Trial registration number: NCT02540889

Numerical studies of suspension system with double spring loaded using the force pulse

The forced vibration of a dependent rear suspension model of the two-axle vehicle, equipped with a 3D model of a double spring and a viscous shock absorber is the subject of consideration. The clearance between the master and auxiliary springs is a specificity of the double suspension construction. Dynamic analysis of such a system has been performed by forcing with different forms of force pulses using the fixed base of force 10 kN. Three different time runs (two trapezoidal and one triangular model) are used as the force impulses. Modelling and analysis taking into consideration contact problems have been developed using the MSC.Software package with a special use of Patran pre-processor and Nastran solver. A finite element method (FEM) has been used in numerical analysis of the suspension model with geometric nonlinearities, viscous damping [9] and time-varying load. The boundary conditions of numerical models correspond to a spring support in the real vehicle suspension. The non-periodic damped vibrations and damped free vibrations of the simplified suspension system are investigated during numerical analysis. Selected results of the model tests have been presented in the form of the timings of the accelerations of the spring elements and of the forces in the suspension damper

Multibody rigid models and 3D FE models in numerical analysis of transport aircraft main landing gear

Dynamic analyses of a transport aircraft landing gear are conducted to determine the effort of such a complex system and provide capabilities to predict their behaviour under hazardous conditions. This kind of investigation with the use of numerical methods implementation is much easier and less expensive than stand tests. Various 3D models of the landing gear part are defined for the multistage static FE analysis. A complete system of the main landing gear was mapped as a deformable 3D numerical model for dynamic analysis with the use of LS-Dyna code. In this 3D deformable FE model, developed in a drop test simulation, the following matters were taken into consideration: contact problems between collaborating elements, the phenomena of energy absorption by a gas-liquid damper placed in the landing gear and the response of the landing gear during the touchdown of a flexible wheel with the ground. The results of numerical analyses for the selected drop tests and the results from the experiments carried out on a real landing gear were used for verification of FE models and a methodology of the landing gear dynamics analysis. The results obtained from the various simulations of the touchdown have proved the effectiveness of the 3D numerical model and how many problems can be solved in the course of only one numerical run, e.g. geometric and material nonlinearities, a question of contact between the mating components, investigation of the landing gear kinematics, investigation of the energy dissipation problem in the whole system and the stresses influence on the structure behaviour, which can appear in some elements due to overload

Field test and numerical studies of the scissors-AVLB type bridge

Scissor bridges are characterized by high mobility and modular structure. A single module-span consists of two spanning parts of the bridge; two main trucks and the support structure. Pin joints are used between modules of the single bridge span. Some aspects of the experimental test and numerical analysis of the scissor-AVLB type bridge operation are presented in this paper. Numerical analyses, presented here, were carried out for the scissors-type BLG bridge with treadways extended as compared to the classical bridge operated up to the present in the Armed Forces of the Republic of Poland. A structural modification of this kind considerably affects any changes in the effort of the force transmitting structure of the bridge. These changes may prove to be disadvantageous to the whole structure because of torsional moments that additionally load the treadways. Giving careful consideration to such operational instances has been highly appreciated because of the possibility of using this kind of bridges while organizing the crossing for vehicles featured with various wheel/track spaces (different from those used previously). The BLG bridge was numerically analysed to assess displacements and distributions of stresses throughout the bridge structure in different loading modes. Because of the complexity of the structure in question and simplifications assumed at the stage of constructing geometric and discrete models, the deformable 3D model of the scissors-type bridge needs verification. Verification of the reliability of models was performed by comparing deflections obtained in the different load modes that corresponded with tests performed on the test stand. It has been shown that the examined changes in conditions of loading the treadways of the bridge are of the greatest effect to the effort of the area of the joint which is attached to the girder bottom. Stress concentrations determined in the analysis are not hazardous to safe operation of the structure

Geological evolution and analysis of confirmed or suspected gas hydrate localities: Volume 10, Basin analysis, formation and stability of gas hydrates of the Aleutian Trench and the Bering Sea

Four major areas with inferred gas hydrates are the subject of this study. Two of these areas, the Navarin and the Norton Basins, are located within the Bering Sea shelf, whereas the remaining areas of the Atka Basin in the central Aleutian Trench system and the eastern Aleutian Trench represent a huge region of the Aleutian Trench-Arc system. All four areas are geologically diverse and complex. Particularly the structural features of the accretionary wedge north of the Aleutian Trench still remain the subjects of scientific debates. Prior to this study, suggested presence of the gas hydrates in the four areas was based on seismic evidence, i.e., presence of bottom simulating reflectors (BSRs). Although the disclosure of the BSRs is often difficult, particularly under the structural conditions of the Navarin and Norton basins, it can be concluded that the identified BSRs are mostly represented by relatively weak and discontinuous reflectors. Under thermal and pressure conditions favorable for gas hydrate formation, the relative scarcity of the BSRs can be attributed to insufficient gas supply to the potential gas hydrate zone. Hydrocarbon gas in sediment may have biogenic, thermogenic or mixed origin. In the four studied areas, basin analysis revealed limited biogenic hydrocarbon generation. The migration of the thermogenically derived gases is probably diminished considerably due to the widespread diagenetic processes in diatomaceous strata. The latter processes resulted in the formation of the diagenetic horizons. The identified gas hydrate-related BSRs seem to be located in the areas of increased biogenic methanogenesis and faults acting as the pathways for thermogenic hydrocarbons