10 research outputs found

    The investigation of acute optic neuritis: a review and proposed protocol

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    High resolution laser range detection using extremely chirped pulses from a mode-locked semiconductor laser

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    Spectral interferemetry is used in conjunction with pairs of time reversed, extremely chirped femtosecond pulses to demonstrate high energies with simultaneous high resolution range measurements using a femtosecond mode-locked semiconductor laser. ©2007 IEEE

    Precision Laser Ranging Using Extremely Chirped Pulses From Chirped Fiber Bragg Gratings

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    Spectrally resolved interferometry combining up-chirped and down-chirped pulses allows for millimeter range resolution in laser ranging applications. Key in our approach is the use of temporally stretched optical pulses of 5 nanoseconds in duration. These stretched pulses were obtained from a femtosecond semiconductor mode-locked laser and were up-chirped and down-chirped using a chirped fiber Bragg grating and recombined to realize spectral interferometry. This approach provides a means to achieve the high pulse energies required for a laser radar application which are easy to achieve using nanosecond pulses but maintains the high spatial resolution associated with femtosecond optical pulses

    The effect of compaction on the mechanical behaviour of mix granulate base course materials and on pavement performance

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    Road and Railroad Research LaboratoryCivil Engineering and Geoscience

    The investigation of acute optic neuritis: a review and proposed protocol

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    Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials

    OCT and Multiple Sclerosis

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