Iron-binding fragments from the N-Terminal and C-Terminal regions of human lactoferrin

Digestion of lactoferrin with pepsin at pH 3.0 gave an iron-binding half-molecule that represents the C-terminal part of the native protein. Tryptic or chymotryptic digestion of 30%/-iron-saturated lactoferrin yielded the N- and C-terminal half molecules, which could be separated by DEAE-Sephadex chromatography. The N- and C-terminal fragments did not show any immunological cross-reaction. The carbohydrate of lactoferrin was distributed equally between the two fragments

A multi-modal utility to assist powered mobility device navigation tasks

© Springer International Publishing Switzerland 2014. This paper presents the development of a shared control systemfor power mobility device users of varying capability in order toreduce carer oversight in navigation. Weighting of a user’s joystick inputagainst a short-tem trajectory prediction and obstacle avoidancealgorithm is conducted by taking into consideration proximity to obstaclesand smoothness of user driving, resulting in capable users rewardedgreater levels of manual control for undertaking maneuvres that can beconsidered more challenging. An additional optional comparison with aVector Field Histogram applied to leader-tracking provides further activities,such as completely autonomous following and a task for the userto follow a leading entity. Indoor tests carried out on university campusdemonstrate the viability of this work, with future trials at a care homefor the disabled intended to show the system functioning in one of itsintended settings

Degradation of AB25 dye in liquid medium by atmospheric pressure non-thermal plasma and plasma combination with photocatalyst TiO2

In this work, degradation of the anthraquinonic dye Acid Blue 25 by non-thermal plasma at atmospheric pressure with and without photocatalyst is investigated. Titanium dioxide (TiO2) is used as a photocatalyst. The dye degradation by plasma in the presence of TiO2 is investigated as a function of TiO2 concentration, dye concentration and pH. The degradation rate is higher in acidic solutions with pH of 2 to 4.3, especially at pH 2, and decreases to 0.38 mg L-1 min(-1) with the increase of pH from 2 to 5.65. A similar effect is observed in basic media, where a higher degradation rate is found at pH = 10.3. The degradation rate increases in the presence of TiO2 compared to the discharge without photocatalysis. The results show that the degradation of the dye increases in the presence of TiO2 until the catalyst load reaches 0.5 g L-1 after which the suppression of AB25 degradation is observed. The results indicate that the tested advanced oxidation processes are very effective for the degradation of AB25 in aqueous solutions

Hypoxia does not influence the response of fish to a mixture of estrogenic chemicals

The official published version can be obtained from the link below - Copyright @ 2009 American Chemical SocietyChemical risk assessment procedures assign a major role to standardized toxicity tests, in which the response of a particular organism to a single test substance is determined under otherwise constant and favorable conditions in the laboratory. This approach fails to consider the potential for chemical interactions, as well as failing to consider how the toxicological response varies, depending on the conditions of exposure. As yet, the issue of confounding factors on chemically mediated effects in wildlife has received little attention, despite the fact that a range of physicochemical parameters, including temperature, water quality, and pH, are known to modify chemical toxicity. Here, we consider how the estrogenic response of fish varies with regard to hypoxia. Fathead minnows (Pimephales promelas) were exposed to a mixture of estrogenic chemicals under hypoxic or normoxic conditions. Their estrogenic response was characterized using an in vivo assay, involving the analysis of the egg yolk protein, vitellogenin (VTG). The results revealed that there was no effect of hypoxia on the VTG response in either treatment group at the end of the exposure period. This suggests that this end point is robust and relatively insensitive to the effects of any physiological changes that arise as a result of hypoxia. The implications of these negative findings are discussed in terms of their relevance with regard to the development of risk assessment policy.This work was funded by a grant from the Natural Environment Research Council(NE/D00389X/1)

Guided Unfoldings for Finding Loops in Standard Term Rewriting

In this paper, we reconsider the unfolding-based technique that we have introduced previously for detecting loops in standard term rewriting. We improve it by guiding the unfolding process, using distinguished positions in the rewrite rules. This results in a depth-first computation of the unfoldings, whereas the original technique was breadth-first. We have implemented this new approach in our tool NTI and compared it to the previous one on a bunch of rewrite systems. The results we get are promising (better times, more successful proofs).Comment: Pre-proceedings paper presented at the 28th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2018), Frankfurt am Main, Germany, 4-6 September 2018 (arXiv:1808.03326

A passive estimator of functional degradation in power mobility device users

© 2015 IEEE. This paper documents the development of a passive technique for assessing a power mobility device user's driving proficiency during everyday driving activities outside formal assessment conditions by therapists. This is approached by first building a model by means of an Artificial Neural Network to infer longer-Term destinations for discretized bouts of travel, and subsequently drawing cues indicative of decline in driving proficiency for the duration of point-To-point navigation rather than relying on instantaneously calculated metrics. This resultant quantity, which we refer to as 'functional degradation', can then provide therapists with additional information concerning user health or serve as a leveraging parameter in combinatory shared-control mobility frameworks. Experiments conducted by able-bodied users subject to simulated noise scaled to varying degrees of functional degradation reveal a quantitative correlation between these longer-Term proficiency metrics and the magnitude of degradation experienced; a promising outcome that sets the scene for a larger-scale clinical trial

A general theory for preferential sampling in environmental networks

This is the final version. Available from the Institute of Mathematical Statistics via the DOI in this recordThis paper presents a general model framework for detecting the preferential sampling of environmental monitors recording an environmental process across space and/or time. This is achieved by considering the joint distribution of an environmental process with a site–selection process that considers where and when sites are placed to measure the process. The environmental process may be spatial, temporal or spatio–temporal in nature. By sharing random effects between the two processes, the joint model is able to establish whether site placement was stochastically dependent of the environmental process under study. Furthermore, if stochastic dependence is identified between the two processes, then inferences about the probability distribution of the spatio–temporal process will change, as will predictions made of the process across space and time. The embedding into a spatio–temporal framework also allows for the modelling of the dynamic site—selection process itself. Real–world factors affecting both the size and location of the network can be easily modelled and quantified. Depending upon the choice of population of locations to consider for selection across space and time under the site– selection process, different insights about the precise nature of preferential sampling can be obtained. The general framework developed in the paper is designed to be easily and quickly fit using the R-INLA package. We apply this framework to a case study involving particulate air pollution over the UK where a major reduction in the size of a monitoring network through time occurred. It is demonstrated that a significant response–biased reduction in the air quality monitoring network occurred, namely the relocation of monitoring sites to locations with the highest pollution levels, and the routine removal of sites at locations with the lowest. We also show that the network was consistently unrepresentative of the levels of particulate matter seen across much of GB throughout the operating life of the network. Finally we show that this may have led to a severe over-reporting of the population–average exposure levels experienced across GB. This could have great impacts on estimates of the health effects of black smoke levels.Natural Science and Engineering Research Council of Canad

Mediating punitiveness: understanding public attitudes towards work-related fatality cases

This paper concerns an empirical investigation into public attitudes towards work-related fatality cases, where organizational offenders cause the death of workers or members of the public. This issue is particularly relevant following the introduction of the Corporate Manslaughter and Corporate Homicide Act 2007 into UK law. Here, as elsewhere, the use of criminal law against companies reflects governmental concerns over public confidence in the law’s ability to regulate risk. The empirical findings demonstrate that high levels of public concern over these cases do not translate into punitive attitudes. Such cases are viewed rationally and constructively, and lead to instrumental rather than purely expressive enforcement preferences

Media coverage and public understanding of sentencing policy in relation to crimes against children

This research examines how the media report on sentences given to those who commit serious crimes against children and how this impacts on public knowledge and attitudes. Three months of press and television coverage were analysed in order to establish the editorial lines that are taken in different sections of the media and how they are promoted by selective reporting of sentencing. Results indicate that a small number of very high profile crimes account for a significant proportion of reporting in this area and often, particularly in the tabloid press, important information regarding sentencing rationale is sidelined in favour of moral condemnation and criticism of the judiciary. Polling data indicate that public attitudes are highly critical of sentencing but also confused about the meaning of tariffs. The article concludes by discussing what can be done to promote a more informed public debate over penal policy in this area

Personalized Medicine: Paradigm Shift in ALK Positive Non-Small Cell Lung Cancer: a Case Report

Background: Since the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the availability of the best treatments to our patients. Case presentation: We present a case of a caucasian male in his fifth decade of life, non-smoker, who highlights the complex journey of ALK-positive patients. This particular case, demonstrates the efficacy and tolerability of the new ALK target therapies, allowing our patients to maintain their routines without compromising the effectiveness of the therapy. Conclusion: Focusing on the reality of ALK positive patients and the impact that this therapy has on the daily lives of our patients, we can contribute to the awareness of this specific pathology.info:eu-repo/semantics/publishedVersio