Recent developments in monetary and financial integration in Asia.

Asia’s share of world trade has expanded constantly over the last two decades. This increase reflects, inter alia, the considerable strengthening of trade links between the countries of the region, fostered by the vertical specialisation of the Asian economies. In the 1980s, the most advanced economies in the region, e.g. Japan, relocated the most labour-intensive stages of their production processes to the newly-industrialised Asian economies like South Korea and Singapore and then, in the 1990s, to emerging Asia, i.e. Indonesia, Malaysia, the Philippines and Thailand. The emergence of China has also given signifi cant impetus to regional trade integration. Surging intra-regional direct investment fl ows have accompanied and shored up trade fl ows, however, portfolio investment fl ows and cross-border bank loans have remained limited. Given that production processes within the region are complementary and that the final destination for exports is outside the region, the lack of a regional exchange rate arrangement in Asia does not appear to be a concern in the short term. Indeed, the regional integration initiatives adopted in Asia in the aftermath of the 1997-1998 financial crisis aim to build further resilience to fi nancial market turbulence. Firstly, deeper and more liquid local bond markets should make it possible to reduce the double financial mismatch, i.e. the currency mismatch and maturity mismatch, which largely sustained the crisis. In this regard, the ASEAN+3 Asian Bond Market Initiative examines the supply-side issues while the Asian Bond Funds initiative of the Executives’ Meeting of East Asia-Pacifi c Central Banks (EMEAP) deals with demand-side issues via the pooling of resources to buy bonds issued by member countries. Secondly, the Chiang Mai Initiative, which consists in a network of currency swap arrangements between the central banks of the ASEAN+3 member states, provides these countries with a regional fi nancial assistance mechanism in the event of a liquidity crisis. The Asian vertical model of production appears to have reached its limit and is evolving towards a more “horizontal” model in terms of both production (substitutability of production processes as a result of the shift towards higher value-added activities) and consumption (expansion of the regional market linked to the growth potential of domestic Chinese demand). Regional monetary co-operation could therefore aim in the future at curbing intra-regional exchange rate fl uctuations in order to promote trade and investment within the region.

Using the Xenopus Developmental Eye Regrowth Stystem to Distinguish the Role of Developmental Versus Regenerative Mechanisms

A longstanding challenge in regeneration biology is to understand the role of developmental mechanisms in restoring lost or damaged tissues and organs. As these body structures were built during embryogenesis, it is not surprising that a number of developmental mechanisms are also active during regeneration. However, it remains unclear whether developmental mechanisms act similarly or differently during regeneration as compared to development. Since regeneration is studied in the context of mature, differentiated tissues, it is difficult to evaluate comparative studies with developmental processes due to the latter’s highly proliferative environment. We have taken a more direct approach to study regeneration in a developmental context (regrowth). Xenopus laevis, the African clawed frog, is a well-established model for both embryology and regeneration studies, especially for the eye. Xenopus eye development is well-defined. Xenopus is also an established model for retinal and lens regeneration studies. Previously, we demonstrated that Xenopus tailbud embryo can successfully regrow a functional eye that is morphologically indistinguishable from an age-matched control eye. In this study, we assessed the temporal regulation of retinal differentiation and patterning restoration during eye regrowth. Our findings showed that during regrowth, cellular patterning and retinal layer formation was delayed by approximately 1 day but was restored by 3 days when compared to eye development. An assessment of the differentiation of ganglion cells, photoreceptor cells, and Müller glia indicated that the retinal birth order generated during regrowth was consistent with that observed for eye development. Thus, retina differentiation and patterning during regrowth is similar to endogenous eye development. We used this eye regrowth model to assess the role of known mechanisms in development versus regrowth. Loss-of-function studies showed that Pax6 was required for both eye development and regrowth whereas apoptosis was only required for regrowth. Together, these results revealed that the mechanisms required for both development and regrowth can be distinguished from regrowth-specific ones. Our study highlights this developmental model of eye regrowth as a robust platform to systematically and efficiently define the molecular mechanisms that are required for regeneration versus development

Learning policies through argumentation-derived evidence (extended abstract)

(c) IFAAMASPublisher PD

Learning policy constraints through dialogue

Publisher PD

Reducing the Number of Sputum Samples Examined and Thresholds for Positivity: An Opportunity to Optimise Smear Microscopy.

SETTING: Urban health clinic, Nairobi. OBJECTIVE: To evaluate the impact on tuberculosis (TB) case detection and laboratory workload of reducing the number of sputum smears examined and thresholds for diagnosing positive smears and positive cases. DESIGN: In this prospective study, three Ziehl-Neelsen stained sputum smears from consecutive pulmonary TB suspects were examined blind. The standard approach (A), > or = 2 positive smears out of 3, using a cut-off of 10 acid-fast bacilli (AFB)/100 high-power fields (HPF), was compared with approaches B, > or = 2 positive smears (> or = 4 AFB/100 HPF) out of 3, one of which is > or = 10 AFB/100 HPF; C, > or = 2 positive smears (> or = 4 AFB/100 HPF) out of 3; D, > or = 1 positive smear (> or = 10 AFB/100 HPF) out of 2; and E, > or = 1 positive smear (> or = 4 AFB/100 HPF) out of 2. The microscopy gold standard was detection of at least one positive smear (> or = 4 AFB/100 HPF) out of 3. RESULTS: Among 644 TB suspects, the alternative approaches detected from 114 (17.7%) (approach B) to 123 cases (19.1%) (approach E) compared to 105 cases (16.3%) for approach A (P < 0.005). Sensitivity ranged between 82.0% (105/128) for A and 96.1% (123/128) for E. The single positive smear approaches reduced the number of smears by 36% compared to approach A. CONCLUSION: Reducing the number of specimens and the positivity threshold to define a positive case increased the sensitivity of microscopy and reduced laboratory workload

Guided atom laser : a new tool for guided atom optics

We present a guided atom laser. A Bose-Einstein condensate (BEC) is created in a crossed hybrid magnetic and an elongated optical trap, which acts as a matterwave guide. Atoms are extracted from the BEC by radio frequency (rf) outcoupling and then guided in the horizontal optical matterwave guide. This method allows to control the acceleration of the beam and to achieve large de Broglie wavelength. We also measure the longitudinal energy of the guided atom laser using atom optical elements based on a blue light barrier

Exploring the Time to Intervene with a Reactive Mass Vaccination Campaign in Measles Epidemics.

The current WHO policy during measles outbreaks focuses on case management rather than reactive vaccination campaigns in urban areas of resource-poor countries having low vaccine coverage. Vaccination campaigns may be costly, or not timely enough to impact significantly on morbidity and mortality. We explored the time available for intervention during two recent epidemics. Our analysis suggests that the spread of measles in African urban settings may not be as fast as expected. Examining measles epidemic spread in Kinshasa (DRC), and Niamey (Niger) reveals a progression of smaller epidemics. Intervening with a mass campaign or in areas where cases have not yet been reported could slow the epidemic spread. The results of this preliminary analysis illustrate the importance of revisiting outbreak response plans

Reducing wasting in young children with preventive supplementation: a cohort study in Niger

OBJECTIVE: To compare the incidence of wasting, stunting, and mortality among children aged 6 to 36 months who are receiving preventive supplementation with either ready-to-use supplementary foods (RUSFs) or ready-to-use therapeutic foods (RUTFs). SUBJECTS AND METHODS: Children aged 6 to 36 months in 12 villages of Maradi, Niger, (n = 1645) received a monthly distribution of RUSFs (247 kcal [3 spoons] per day) for 6 months or RUTFs (500-kcal sachet per day) for 4 months. We compared the incidence of wasting, stunting, and mortality among children who received preventive supplementation with RUSFs versus RUTFs. RESULTS: The effectiveness of RUSF supplementation depended on receipt of a previous preventive intervention. In villages in which a preventive supplementation program was previously implemented, the RUSF strategy was associated with a 46% (95% confidence interval [CI]: 6%-69%) and 59% (95% CI: 17%-80%) reduction in wasting and severe wasting, respectively. In contrast, in villages in which the previous intervention was not implemented, we found no difference in the incidence of wasting or severe wasting according to type of supplementation. Compared with the RUTF strategy, the RUSF strategy was associated with a 19% (95% CI: 0%-34%) reduction in stunting overall. CONCLUSION: We found that the relative performance of a 6-month RUSF supplementation strategy versus a 4-month RUTF strategy varied with receipt of a previous nutritional intervention. Contextual factors will continue to be important in determining the dose and duration of supplementation that will be most effective, acceptable, and sustainable for a given setting