Hydrothermal synthesis of zinc stannate nanoparticles for antibacterial applications

AbstractA facile and economical hydrothermal method was used to synthesise Zn2SnO4 nanoparticles with cubic spinel structure. The crystallography and optical properties of the as-synthesised nanoparticles were studied using X-ray diffraction (XRD) and UV–visible spectroscopy (UV–vis). The morphology of the nanoparticles was observed using field emission scanning electron microscopy (FESEM). The synergistic antibacterial effect of Zn2SnO4 nanoparticles against Gram-positive and Gram-negative pathogenic bacteria was investigated. These results indicate that the Zn2SnO4 nanoparticles have potent antibacterial activity against both Gram-positive and Gram-negative bacteria and can be used as a bactericidal agent to prevent and control the spread and persistence of infectious diseases

In vitro antibacterial and anticancer activity of copper oxide nanostructures in human breast cancer Michigan Cancer Foundation-7 cells

Objective: The use of nanoparticles (NPs) in cancer diagnosis and treatment is a rapidly developing area of nanotechnology. The main objective of this research work is to synthesize copper oxide (CuO) NPs and to investigate its vitro anticancer and antibacterial property. Methods: The CuO NPs were synthesized via a facile and cost-effective precipitation method using cupric acetate (monohydrate) (CuAc 2 .2H 2 O), sodium hydroxide, and glacial acetic acid. By varying the pH of the precursor solution, the morphology, particle size, and reaction rate of the NPs could be well tailored. The prepared CuO NPs were characterized by X-ray diffraction, ultraviolet-visible spectroscopy, Fourier transform infrared analysis, and scanning electron microscopy. Results: The results revealed a well crystalline structure with leaf-like morphology. By controlling the pH of the solution, particle size and morphology of the NPs are altered. The synthesized CuO NPs have been screened for its antibacterial potency against Gram-positive (Methicillin-resistant Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Salmonella Paratyphi, Klebsiella pneumonia, and Enterobacter aerogenes) bacterial strains. The as-synthesized NPs were found to be remarkable in inhibiting pathogenic bacteria. The anticancer activity reveals the dose-dependent influence of CuO NPs against human breast cancer cell line Michigan Cancer Foundation-7 (MCF-7). Conclusions: The results suggested that CuO NPs have a wide range of antibacterial applications which can be used to control the spread and infection of a variety of bacterial strains. The CuO NPs showed promising anticancer activity against human breast cancer cell line (MCF-7). Overall, CuO NPs are an effective candidate for pharmaceutical, biomedical, and environmental applications