Leaving the nest: the rise of regional financial arrangements and the future of global governance

This article examines the impact of regional financial arrangements (RFAs) on the global liquidity regime. It argues that the design of RFAs could potentially alter the global regime, whether by strengthening it and making it more coherent or by decentring the International Monetary Fund (IMF) and destabilizing it. To determine possible outcomes, this analysis deploys a ‘middle‐up’ approach that focuses on the institutional design of these RFAs. It first draws on the rational design of institutions framework to identify the internal characteristics of RFAs that are most relevant to their capabilities and capacities. It then applies these insights to the interactions of RFAs with the IMF, building on Aggarwal's (1998) concept of ‘nested’ versus ‘parallel’ institutions, to create an analytical lens through which to assess the nature and sustainability of nested linkages. Through an analysis of the Chiang Mai Initiative Multilateralization (CMIM) and the Latin American Reserve Fund (FLAR), the article demonstrates the usefulness of this lens. It concludes by considering three circumstances in which fault lines created by these RFAs’ institutional design could be activated, permitting an institution to ‘leave the nest’, including changing intentions of principals, creation of parallel capabilities and facilities, and failure of the global regime to address regional needs in a crisis.The authors would like to thank Veronica Artola, Masatsugu Asakawa, Ana Maria Carrasquilla, Junhong Chang, Paolo Hernando, Hoe Ee Khor, Kazunori Koike, Jae Young Lee, Ser-Jin Lee, Guillermo Perry, Yoichi Nemoto, Freddy Trujillo, Masaaki Watanabe, Yasuto Watanabe, Akihiko Yoshida, and others who wished to remain anonymous, for their generosity in providing in-person interviews. Further, the authors would like to thank various central bank and ministry of finance officials of both FLAR and CMIM member countries. We also thank Jose Antonio Ocampo, Diana Barrowclough, and participants in the 'Beyond Bretton Woods' Workshop at Boston University (where an earlier version of this article was presented in September 2017) for their feedback on our broader research projects on RFAs. Last but not least, the authors wish to thank the anonymous referees for their constructive comments. This work builds upon previous work funded by UNCTAD and the Global Economic Governance Initiative at the Global Development Policy Center at Boston University. (UNCTAD; Global Economic Governance Initiative at the Global Development Policy Center at Boston University)Accepted manuscrip

UČINAK SELEKCIJE SNIŽENJA STABLJIKE NA UROD I KOMPONENTE URODA ZRNA JEČMA

This investigation deals with the effects of selection for short stem in population lines of the F4 generation derived from the barley cross between Timura x Osk. 4.208´2-84 developed by the single seed descent and pedigree method. Direct genetic gain from reducing the stem length was found to be 10.22 % at dense planting (400 kernels/m2) and 11.47 % at wide-spaced planting (100 kernels/m2). It was found that stem length had relatively high heritability (0.643 and 0.735). Large negative effects of reducing the stem length at wide-spaced and dense planting were estimated for the grain yield per plant, grain yield per plot and number of fertile tillers. Less pronounced negative effects were found for the grain weight per spike and grain number per spike. Phenotypic and genotypic correlations between stem length and other traits were mostly significant and positive with higher values at dense planting. Selection for a short stem length was efficient for the improvement of this trait. However, unfavorable correlations have significantly affected undesired expression of other traits, especially grain yield per plant, grain yield per plot and number of fertile tillers. Any further decrease of plant height should be accompanied by the appropriate selection for other traits, especially grain yield per plant, mass of one grain and harvest index.U radu su istraženi učinci selekcije na kraću stabljiku kod ječma u populaciji linija F4 generacije izvedene iz kombinacije križanja Timura x Osk.4.208´2-84 pomoću metode potomstva sjemenke po biljci (SSD) i pedigree metode. Ostvarena izravna genetska dobit sniženja stabljike bila je 10,22 % u gustoj sjetvi (400 zrna/m2 ) i 11,47 % u rijetkoj sjetvi (100 zrna/m2 ). Utvrđeno je da je dužina stabljike svojstvo relativno visokog heritabiliteta (0,643 i 0,735). Jaki negativni učinci sniženja dužine stabljike u rijetkoj i gustoj sjetvi procijenjeni su za urod zrna po biljci, urod zrna po parceli i broj plodnih vlati. Manje naglašeni negativni učinci utvrđeni su za masu zrna po klasu i broj zrna po klasu. Fenotipske i genotipske korelacije između dužine stabljike i drugih svojstava bile su uglavnom značajne i pozitivne s višim vrijednostima u gustoj sjetvi. Selekcija na skraćenje stabljike bila je učinkovita za poboljšanje toga svojstva. Međutim, nepovoljne korelacije značajno su utjecale na neželjenu ekspresiju drugih svojstava, naročito na urod zrna po biljci, urod zrna po parceli i broj plodnih vlati. Daljnje snižavanje visine stabljike trebalo bi biti praćeno i odgovarajućom selekcijom na druga svojstva, posebno urod zrna po biljci, masu zrna i žetveni indeks

UČINAK SELEKCIJE SNIŽENJA STABLJIKE NA UROD I KOMPONENTE URODA ZRNA JEČMA

This investigation deals with the effects of selection for short stem in population lines of the F4 generation derived from the barley cross between Timura x Osk. 4.208´2-84 developed by the single seed descent and pedigree method. Direct genetic gain from reducing the stem length was found to be 10.22 % at dense planting (400 kernels/m2) and 11.47 % at wide-spaced planting (100 kernels/m2). It was found that stem length had relatively high heritability (0.643 and 0.735). Large negative effects of reducing the stem length at wide-spaced and dense planting were estimated for the grain yield per plant, grain yield per plot and number of fertile tillers. Less pronounced negative effects were found for the grain weight per spike and grain number per spike. Phenotypic and genotypic correlations between stem length and other traits were mostly significant and positive with higher values at dense planting. Selection for a short stem length was efficient for the improvement of this trait. However, unfavorable correlations have significantly affected undesired expression of other traits, especially grain yield per plant, grain yield per plot and number of fertile tillers. Any further decrease of plant height should be accompanied by the appropriate selection for other traits, especially grain yield per plant, mass of one grain and harvest index.U radu su istraženi učinci selekcije na kraću stabljiku kod ječma u populaciji linija F4 generacije izvedene iz kombinacije križanja Timura x Osk.4.208´2-84 pomoću metode potomstva sjemenke po biljci (SSD) i pedigree metode. Ostvarena izravna genetska dobit sniženja stabljike bila je 10,22 % u gustoj sjetvi (400 zrna/m2 ) i 11,47 % u rijetkoj sjetvi (100 zrna/m2 ). Utvrđeno je da je dužina stabljike svojstvo relativno visokog heritabiliteta (0,643 i 0,735). Jaki negativni učinci sniženja dužine stabljike u rijetkoj i gustoj sjetvi procijenjeni su za urod zrna po biljci, urod zrna po parceli i broj plodnih vlati. Manje naglašeni negativni učinci utvrđeni su za masu zrna po klasu i broj zrna po klasu. Fenotipske i genotipske korelacije između dužine stabljike i drugih svojstava bile su uglavnom značajne i pozitivne s višim vrijednostima u gustoj sjetvi. Selekcija na skraćenje stabljike bila je učinkovita za poboljšanje toga svojstva. Međutim, nepovoljne korelacije značajno su utjecale na neželjenu ekspresiju drugih svojstava, naročito na urod zrna po biljci, urod zrna po parceli i broj plodnih vlati. Daljnje snižavanje visine stabljike trebalo bi biti praćeno i odgovarajućom selekcijom na druga svojstva, posebno urod zrna po biljci, masu zrna i žetveni indeks

A Survey on Approximation Mechanism Design without Money for Facility Games

In a facility game one or more facilities are placed in a metric space to serve a set of selfish agents whose addresses are their private information. In a classical facility game, each agent wants to be as close to a facility as possible, and the cost of an agent can be defined as the distance between her location and the closest facility. In an obnoxious facility game, each agent wants to be far away from all facilities, and her utility is the distance from her location to the facility set. The objective of each agent is to minimize her cost or maximize her utility. An agent may lie if, by doing so, more benefit can be obtained. We are interested in social choice mechanisms that do not utilize payments. The game designer aims at a mechanism that is strategy-proof, in the sense that any agent cannot benefit by misreporting her address, or, even better, group strategy-proof, in the sense that any coalition of agents cannot all benefit by lying. Meanwhile, it is desirable to have the mechanism to be approximately optimal with respect to a chosen objective function. Several models for such approximation mechanism design without money for facility games have been proposed. In this paper we briefly review these models and related results for both deterministic and randomized mechanisms, and meanwhile we present a general framework for approximation mechanism design without money for facility games

International criteria for electrocardiographic interpretation in athletes: Consensus statement.

Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete. A critical need exists for physician education in modern ECG interpretation that distinguishes normal physiological adaptations in athletes from distinctly abnormal findings suggestive of underlying pathology. Since the original 2010 European Society of Cardiology recommendations for ECG interpretation in athletes, ECG standards have evolved quickly, advanced by a growing body of scientific data and investigations that both examine proposed criteria sets and establish new evidence to guide refinements. On 26-27 February 2015, an international group of experts in sports cardiology, inherited cardiac disease, and sports medicine convened in Seattle, Washington (USA), to update contemporary standards for ECG interpretation in athletes. The objective of the meeting was to define and revise ECG interpretation standards based on new and emerging research and to develop a clear guide to the proper evaluation of ECG abnormalities in athletes. This statement represents an international consensus for ECG interpretation in athletes and provides expert opinion-based recommendations linking specific ECG abnormalities and the secondary evaluation for conditions associated with SCD

A preliminary audit of medical and aid provision in English Rugby union clubs:compliance with Regulation 9

BackgroundGoverning bodies are largely responsible for the monitoring and management of risks associated with a safe playing environment, yet adherence to regulations is currently unknown. The aim of this study was to investigate and evaluate the current status of medical personnel, facilities, and equipment in Rugby Union clubs at regional level in England.MethodsA nationwide cross-sectional survey of 242 registered clubs was undertaken, where clubs were surveyed online on their current medical personnel, facilities, and equipment provision, according to regulation 9 of the Rugby Football Union (RFU).ResultsOverall, 91 (45. 04%) surveys were returned from the successfully contacted recipients. Of the completed responses, only 23.61% (n = 17) were found to be compliant with regulations. Furthermore, 30.56% (n = 22) of clubs were unsure if their medical personnel had required qualifications; thus, compliance could not be determined. There was a significant correlation (p = −0.029, r = 0.295) between club level and numbers of practitioners. There was no significant correlation indicated between the number of practitioners/number of teams and number of practitioners/number of players. There were significant correlations found between club level and equipment score (p = 0.003, r = −0.410), club level and automated external defibrillator (AED) access (p = 0.002, r = −0.352) and practitioner level and AED access (p = 0.0001, r = 0.404). Follow-up, thematic analysis highlighted widespread club concern around funding/cost, awareness, availability of practitioners and AED training.ConclusionThe proportion of clubs not adhering overall compliance with Regulation 9 of the RFU is concerning for player welfare, and an overhaul, nationally, is required

Using Research Metrics to Improve Timelines: Proceedings from the 2nd Annual CTSA Clinical Research Management Workshop

The Clinical and Translational Science Award (CTSA) Consortium Workshop was conceived as a venue to foster communication among Academic Medical Centers (AMCs) in the development of methods to improve clinical research management. The consortium, comprised of 46 awardee sites as of 2009, many with multiple AMCs, is expected to expand to 60 sites when fully implemented. At the 2nd Annual CTSA Clinical Research Management Workshop held on June 22 nd and 23 rd , 2009, on the National Institutes of Health (NIH) campus, consortium members and potential CTSA sites gathered with stakeholders from private industry, the NIH, the Food and Drug Administration, and private research organizations, to formulate a plan to address challenges in clinical research management. Specific aims included improving protocol processing and sharing process improvement initiatives in the expectation that best practices will be implemented and improvements will be measured and reported. The findings presented at this workshop indicated significant variance in Institutional Review Board approval of protocols and contract execution by AMC and CTSA sites. Most represented marked delays compared to non-AMC sites and that, as a likely consequence, AMCs were later to enroll patients and/or meet enrollment targets compared to dedicated or professional sites. Clin Trans Sci 2010; Volume 3: 305–308Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79218/1/j.1752-8062.2010.00246.x.pd

ALELNA VARIJABILNOST HRVATSKIH KULTIVARA PŠENICE NA MIKROSATELITNOM LOKUSU XGWM261

The plant height of wheat is an important quantitative trait, controlled by several genes with strong effect. However, in worldwide wheat breeding, only several of those genes have been used. Rht8 (Reduced Height Gene) is especially important in agro-climatic conditions of South-East Europe. Because of its close linkage with dwarfing gene Rht8, microsatellite marker gwm261 has been accepted as the diagnostic molecular marker for gene Rht8. In this study, allelic variability at the locus Xgwm261 for 122 Croatian and foreign wheat cultivars by means of microsatellite marker gwm261 was determined. A 192 base pairs allele at the locus Xgwm261 was found for 84 Croatian cultivars. The genetic heritage of Croatian cultivars at the locus Xgwm261 is the consequence of new parental components usage, carriers of short plant and early maturity attributes and the consequent selection of progeny with these traits during breeding process. The results of this research will be helpful in characterization of domestic wheat cultivars, as well as in more accurate selection of parents for hybridization purposes.Visina biljke pšenice važno je kvantitativno svojstvo kontrolirano s više gena jakog učinka. Međutim, u oplemenjivanju pšenice u svijetu, najčešće se koristi samo nekoliko takvih gena. U agroklimatskim uvjetima jugoistoka Europe posebno je važan gen Rht8 (Reduced Height Gene). Mikrosatelit gwm261 je, zbog svoje bliske vezanosti s lokusom za gen Rht8, prihvaćen kao dijagnostički molekularni biljeg gena Rht8. U ovome istraživanju je pomoću mikrosatelita gwm261 utvrđena alelna varijabilnost na lokusu Xgwm261 za 122 hrvatska i strana kultivara pšenice. Alel sa 192 para baza na lokusu Xgwm261 utvrđen je za 84 hrvatska kultivara. Genetsko naslijeđe hrvatskih kultivara na lokusu Xgwm261 posljedica je korištenja novih roditelja, nositelja svojstava niže stabljike i ranozrelosti te odabira potomstva s tim svojstvima tijekom oplemenjivačkoga procesa. Rezultati istraživanja pomoći će u karakterizaciji domaćih kultivara pšenice, kao i u preciznijem odabiru roditelja u svrhu križanja

Aluminum-induced de novo bone formation in the beagle. A parathyroid hormone-dependent event.

L'aluminium stimule la néo-ostéogenèse et produit un bilan osseux positif. Cependant cet effet semble dépendre de la disponibilité d'un pool d'ostéoblastes fonctionnels qui, s'il est réduit par la thyroparathyroïdectomie limite l'expression de la néoformation d'os provoquée par l'aluminium

ALELNA VARIJABILNOST HRVATSKIH KULTIVARA PŠENICE NA MIKROSATELITNOM LOKUSU XGWM261

The plant height of wheat is an important quantitative trait, controlled by several genes with strong effect. However, in worldwide wheat breeding, only several of those genes have been used. Rht8 (Reduced Height Gene) is especially important in agro-climatic conditions of South-East Europe. Because of its close linkage with dwarfing gene Rht8, microsatellite marker gwm261 has been accepted as the diagnostic molecular marker for gene Rht8. In this study, allelic variability at the locus Xgwm261 for 122 Croatian and foreign wheat cultivars by means of microsatellite marker gwm261 was determined. A 192 base pairs allele at the locus Xgwm261 was found for 84 Croatian cultivars. The genetic heritage of Croatian cultivars at the locus Xgwm261 is the consequence of new parental components usage, carriers of short plant and early maturity attributes and the consequent selection of progeny with these traits during breeding process. The results of this research will be helpful in characterization of domestic wheat cultivars, as well as in more accurate selection of parents for hybridization purposes.Visina biljke pšenice važno je kvantitativno svojstvo kontrolirano s više gena jakog učinka. Međutim, u oplemenjivanju pšenice u svijetu, najčešće se koristi samo nekoliko takvih gena. U agroklimatskim uvjetima jugoistoka Europe posebno je važan gen Rht8 (Reduced Height Gene). Mikrosatelit gwm261 je, zbog svoje bliske vezanosti s lokusom za gen Rht8, prihvaćen kao dijagnostički molekularni biljeg gena Rht8. U ovome istraživanju je pomoću mikrosatelita gwm261 utvrđena alelna varijabilnost na lokusu Xgwm261 za 122 hrvatska i strana kultivara pšenice. Alel sa 192 para baza na lokusu Xgwm261 utvrđen je za 84 hrvatska kultivara. Genetsko naslijeđe hrvatskih kultivara na lokusu Xgwm261 posljedica je korištenja novih roditelja, nositelja svojstava niže stabljike i ranozrelosti te odabira potomstva s tim svojstvima tijekom oplemenjivačkoga procesa. Rezultati istraživanja pomoći će u karakterizaciji domaćih kultivara pšenice, kao i u preciznijem odabiru roditelja u svrhu križanja