2,099 research outputs found
Deformation of crosslinked semiflexible polymer networks
Networks of filamentous proteins play a crucial role in cell mechanics. These
cytoskeletal networks, together with various crosslinking and other associated
proteins largely determine the (visco)elastic response of cells. In this letter
we study a model system of crosslinked, stiff filaments in order to explore the
connection between the microstructure under strain and the macroscopic response
of cytoskeletal networks. We find two distinct regimes as a function primarily
of crosslink density and filament rigidity: one characterized by affine
deformation and one by non-affine deformation. We characterize the crossover
between these two.Comment: Typos fixed and some technical details clarified. To appear in Phys.
Rev. Let
Non-equilibrium mechanics and dynamics of motor activated gels
The mechanics of cells is strongly affected by molecular motors that generate
forces in the cellular cytoskeleton. We develop a model for cytoskeletal
networks driven out of equilibrium by molecular motors exerting transient
contractile stresses. Using this model we show how motor activity can
dramatically increase the network's bulk elastic moduli. We also show how motor
binding kinetics naturally leads to enhanced low-frequency stress fluctuations
that result in non-equilibrium diffusive motion within an elastic network, as
seen in recent \emph{in vitro} and \emph{in vivo} experiments.Comment: 21 pages, 8 figure
Mechanics and force transmission in soft composites of rods in elastic gels
We report detailed theoretical investigations of the micro-mechanics and bulk
elastic properties of composites consisting of randomly distributed stiff
fibers embedded in an elastic matrix in two and three dimensions. Recent
experiments published in Physical Review Letters [102, 188303 (2009)] have
suggested that the inclusion of stiff microtubules in a softer, nearly
incompressible biopolymer matrix can lead to emergent compressibility. This can
be understood in terms of the enhancement of the compressibility of the
composite relative to its shear compliance as a result of the addition of stiff
rod-like inclusions. We show that the Poisson's ratio of such a composite
evolves with increasing rod density towards a particular value, or {\em fixed
point}, independent of the material properties of the matrix, so long as it has
a finite initial compressibility. This fixed point is in three
dimensions and in two dimensions. Our results suggest an important
role for stiff filaments such as microtubules and stress fibers in cell
mechanics. At the same time, our work has a wider elasticity context, with
potential applications to composite elastic media with a wide separation of
scales in stiffness of its constituents such as carbon nanotube-polymer
composites, which have been shown to have highly tunable mechanics.Comment: 10 pages, 8 figure
The mechanical response of semiflexible networks to localized perturbations
Previous research on semiflexible polymers including cytoskeletal networks in
cells has suggested the existence of distinct regimes of elastic response, in
which the strain field is either uniform (affine) or non-uniform (non-affine)
under external stress. Associated with these regimes, it has been further
suggested that a new fundamental length scale emerges, which characterizes the
scale for the crossover from non-affine to affine deformations. Here, we extend
these studies by probing the response to localized forces and force dipoles. We
show that the previously identified nonaffinity length [D.A. Head et al. PRE
68, 061907 (2003).] controls the mesoscopic response to point forces and the
crossover to continuum elastic behavior at large distances.Comment: 16 pages, 18 figures; substantial changes to text and figures to
clarify the crossover to continuum elasticity and the role of finite-size
effect
The chemical composition and nutritive value of Australian pulses
Grain legumes are the harvested seed of leguminous crops, typically peas, beans and their close relatives within the Fabaceae. Another term for many of these crops is pulses. In Australia, generally grain legumes are referred to as pulses. The term pulse is derived from the Latin puls meaning that the seed or grain can be made into a thick soup or pottage. The term pulse is most commonly associated with the food legumes whereas grain legumes are mostly associated with the feed industry. The terms are interchangeable, but with few exceptions (notably chickpeas, lentils and mung beans), the majority of the crops are used for animal feed. Both soybeans and peanuts are leguminous plants; however they are traditionally regarded as oilseed crops, and will not be discussed here.https://researchlibrary.agric.wa.gov.au/books/1020/thumbnail.jp
A narrative synthesis of factors that affect women speaking up about early warning signs and symptoms of pre-eclampsia and responses of healthcare staff.
BACKGROUND: One of the challenges for treating pre-eclampsia and preventing further deterioration is determining how best to enable early detection. If women or their partners and families are able to raise early warnings about potential signs and symptoms of pre-eclampsia in pregnancy, birth and in the postnatal period, women may be able to receive earlier intervention to prevent severe pre-eclampsia from developing. The aim of this study was to improve understanding of factors affecting the ability of women to recognise symptoms and signs of pre-eclampsia/eclampsia and seek appropriate medical help and factors affecting health care professionals' responses to women and their families who 'speak up' about early warning signs and symptoms. METHODS: A narrative synthesis was conducted of evidence relevant to address the research question. The following electronic data bases were searched for qualitative studies which met inclusion criteria from January 1980 to April 2016; Medline, CINAHL, HMIC, PsycINFO, Embase, BNI, ASSIA, Scopus, Maternity and Infant Care, Web of Science, Google Scholar, Cochrane, JBI and IBSS with the support of an Information Service Consultant. RESULTS: Following thematic analysis, three themes were identified; 1: Women's understanding and knowledge of pre-eclampsia/eclampsia; 2: Factors affecting help seeking behaviour from perspectives of women and their families'; 3: Factors affecting staff response. There was widespread lack of knowledge and understanding of signs and symptoms of pre-eclampsia/eclampsia among women and their families, with some women not exhibiting signs and symptoms of pre-eclampsia or unable to distinguish them from 'normal' pregnancy changes. CONCLUSIONS: Women and their families not only need to be made aware of signs and symptoms of pre-eclampsia/eclampsia but also require information on the most effective ways to seek urgent medical assessment and care. Some women did not experience prodromal signs and symptoms, which raises concerns about how women and families can detect early onset, and is an issue which needs further exploration. There is very limited research exploring clinical staff response to women who raise concerns about their health when experiencing symptoms and signs of pre-eclampsia/eclampsia with further research needed if safety and quality of care are to be improved
Magnetic anisotropy of vicinal (001) fcc Co films: role of crystal splitting and structure relaxation in step-decoration effect
The uniaxial in-plane magnetic anisotropy (UIP-MA) constant is calculated for
a single step on the (001) surface of fcc Co() films. The calculations are
done for both an undecorated step and the step decorated with one or more, up
to 7, Cu wires. Our objective is to explain the mechanisms by which the
decoration decreases the UIP-MA constant, which is the effect observed
experimentally for ultrathin Co films deposited on vicinal (001) Cu surfaces
and can lead to reorientation of magnetization within the film plane.
Theoretical calculations performed with a realistic tight-binding model show
that the step decoration changes the UIP-MA constant significantly only if the
splitting between the on-site energies of various -orbitals is included for
atoms located near the step edge. The local relaxation of atomic structure
around the step is also shown to have a significant effect on the shift of the
UIP-MA constant. The influence of these two relevant factors is analyzed
further by examining individual contributions to the UIP-MA constant from atoms
around the step. The magnitude of the obtained UIP-MA shift agrees well with
experimental data. It is also found that an additional shift due to possible
charge transfer between Cu and Co atoms is very small.Comment: 12 pages,9 figures, RevTeX, submitted to Physical Review B version 3:
additions to content version 2: minor correction
Velocity distributions in dissipative granular gases
Motivated by recent experiments reporting non-Gaussian velocity distributions
in driven dilute granular materials, we study by numerical simulation the
properties of 2D inelastic gases. We find theoretically that the form of the
observed velocity distribution is governed primarily by the coefficient of
restitution and , the ratio between the average number of
heatings and the average number of collisions in the gas. The differences in
distributions we find between uniform and boundary heating can then be
understood as different limits of , for and
respectively.Comment: 5 figure
One-Bead Microrheology with Rotating Particles
We lay the theoretical basis for one-bead microrheology with rotating
particles, i.e, a method where colloids are used to probe the mechanical
properties of viscoelastic media. Based on a two-fluid model, we calculate the
compliance and discuss it for two cases. We first assume that the elastic and
fluid component exhibit both stick boundary conditions at the particle surface.
Then, the compliance fulfills a generalized Stokes law with a complex shear
modulus whose validity is only limited by inertial effects, in contrast to
translational motion. Secondly, we find that the validity of the Stokes regime
is reduced when the elastic network is not coupled to the particleComment: 7 pages, 5 figures, submitted to Europhys. Let
- …