Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis

BACKGROUND: The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS: Two cohorts were compared: one was a group with young-onset PrCa, tested for germline BRCA2 mutations (6 of 263 cases had a germline BRAC2 mutation), and the second was a validation set consisting of a clinical set from Manchester of known BRCA2 mutuation carriers (15 cases) with PrCa. Survival data were compared with a control series of patients in a single clinic as determined by Kaplan-Meier estimates. Loss of heterozygosity was tested for in the DNA of tumour tissue of the young-onset group by typing four microsatellite markers that flanked the BRCA2 gene, followed by sequencing. RESULTS: Median survival of all PrCa cases with a germline BRCA2 mutation was shorter at 4.8 years than was survival in controls at 8.5 years (P = 0.002). Loss of heterozygosity was found in the majority of tumours of BRCA2 mutation carriers. Multivariate analysis confirmed that the poorer survival of PrCa in BRCA2 mutation carriers is associated with the germline BRCA2 mutation per se. CONCLUSION: BRCA2 germline mutation is an independent prognostic factor for survival in PrCa. Such patients should not be managed with active surveillance as they have more aggressive disease. British Journal of Cancer (2010) 103, 918-924. doi:10.1038/sj.bjc.6605822 www.bjcancer.com Published online 24 August 2010 (C) 2010 Cancer Research U

Catálogo de autoridades da Rede BIM (DPHDM): Estudo de caso no tratamento de registros de pontos de acesso

Identificar possíveis problemas na alimentação da base de autoridades de assuntos da Rede BIM através da utilização do software Pergamum, e contribuir para padronização de seus pontos de acesso. A partir da revisão da literatura proposta, considera a importância da recuperação da informação para sua disseminação e ainda faz um breve levantamento dos padrões internacionais utilizados para esse fim. A metodologia utilizada envolveu a análise da base, limitada à letra “c” do alfabeto, e se propôs a detectar possíveis inconsistências existentes. Os principais problemas encontrados foram: falhas de grafia, falhas de entrada de cabeçalhos e duplicidade de assuntos. Os resultados práticos para a Rede BIM são: agilização dos serviços de catalogação e referência da Rede BIM, maior controle bibliográfico e facilidade na recuperação de itens nas pesquisas dos usuários. O Estudo de caso se propõe a contribuir com esclarecimentos quanto a equívocos cometidos, de forma a auxiliar na padronização e documentação do processo de alimentação da base de autoridades de assuntos pelos bibliotecários das 45 organizações militares, possibilitando benefícios aos serviços de catalogação e referência e finalmente, propiciando um atendimento mais prático e ágil ao usuário da Rede BIM

Reynolds-Averaged Navier-Stokes Calculations Of Unsteady Turbulent Flow

In this study, a combination of the unsteady incompressible Navier-Stokes equations in vorticityvelocity formulation and the Algebraic Stress Model (ASM) of Gatski and Speziale (1996) is employed for Unsteady Reynolds Averaged Navier-Stokes (URANS) calculations of turbulent boundary layer flows. The Navier-Stokes equations are solved using a fourth-order compact difference scheme in space and a fourth-order Runge-Kutta method in time. The highly accurate numerical method greatly reduces the possibility of contamination of the results by second-order artificial dissipation from the numerical schemes. A flat plate boundary layer subjected to a strong adverse pressure gradient with laminar separation and turbulent reattachment is investigated. Performing URANS calculations for this flow, we found that unsteady vortical structures remain in the flow field despite the large "effective eddy viscosity" produced by the turbulence model (ASM). This is due to the fact that a special function is ..

A Multiple Regime Nonlinear Asymmetric AR(p)-GARCH(1,1) Model

In this article a multiple regime extension for the Heston-Nandi GARCH(1,1) model is presented to describe the asymmetries and intermittent dynamics in financial volatility. The statistical properties and the estimation of their parameters are addressed in detail. The number of regimes in the model is determined through a statistical procedure based on a novel robust Lagrange Multiplier (LM) specification. The ability of the model to forecast financial market volatility is empirically compared to other GARCH models for a set comprising some of the major world stock indexes and their corresponding foreign exchange rates during the recent financial crisis