81 research outputs found

    Long-term changes in drought indices in eastern and central Europe

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    This study analyses long-term changes in drought indices (Standardised Precipitation Index—SPI, Standardised Precipitation–Evapotranspiration Index—SPEI) at 1 and 3 months scales at 182 stations in 11 central and eastern European countries during 1949–2018. For comparative purposes, the necessary atmospheric evaporative demand (AED) to obtain SPEI was calculated using two methods, Hargreaves-Samani (SPEIH) and Penman-Monteith (SPEIP). The results show some relevant changes and tendencies in the drought indices. Statistically significant increase in SPI and SPEI during the cold season (November–March), reflecting precipitation increase, was found in the northern part of the study region, in Estonia, Latvia, Lithuania, northern Belarus and northern Poland. In the rest of study domain, a weak and mostly insignificant decrease prevailed in winter. Summer season (June–August) is characterized by changes in the opposite sign. An increase was observed in the north, while a clear decrease in SPEI, reflecting a drying trend, was typical for the southern regions: the Czech Republic, Slovakia, Hungary, Romania, Moldova and southern Poland. A general drying tendency revealed also in April, which was statistically significant over a wide area in the Czech Republic and Poland. Increasing trends in SPI and SPEI for September and October were detected in Romania, Moldova and Hungary. The use of SPEI instead of SPI generally enhances drying trends

    Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets.

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    Platelets protect the vascular system during damage or inflammation, but platelet activation can result in pathological thrombosis. Activated platelets release a variety of extracellular vesicles (EVs). EVs shed from the plasma membrane often expose phosphatidylserine (PS). These EVs are pro-thrombotic and increased in number in many cardiovascular and metabolic diseases. The mechanisms by which PS-exposing EVs are shed from activated platelets are not well characterised. Cholesterol-rich lipid rafts provide a platform for coordinating signalling through receptors and Ca2+ channels in platelets. We show that cholesterol depletion with methyl-β-cyclodextrin or sequestration with filipin prevented the Ca2+-triggered release of PS-exposing EVs. Although calpain activity was required for release of PS-exposing, calpain-dependent cleavage of talin was not affected by cholesterol depletion. P2Y12 and TPα, receptors for ADP and thromboxane A2, respectively, have been reported to be in platelet lipid rafts. However, the P2Y12 antagonist, AR-C69931MX, or the cyclooxygenase inhibitor, aspirin, had no effect on A23187-induced release of PS-exposing EVs. Together, these data show that lipid rafts are required for release of PS-exposing EVs from platelets.Isaac Newton Trust/ Wellcome Trust ISSF/University of Cambridge Joint Research Grant British Heart Foundation grant SP/15/7/3156

    Cyclic dormancy, temperature and water availability control germination of Carrichtera annua, an invasive species in chenopod shrublands

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    © 2008 Ecological Society of AustraliaWe studied the germination of seeds of Carrichtera annua L. from a single cohort, stored in the field for up to 18 months, when retrieved at different times and subject to different combinations of temperature and water availability. Germination was affected by season of retrieval, and temperature and water availability in a complex interactive way. Germination rates were lowest when seeds were retrieved during summer or spring, but seeds germinated readily when retrieved during autumn and winter, if exposed to temperatures simulating autumn or winter conditions, and provided water equivalent to at least 50% field capacity. High temperatures and low water availability reduced germination substantially. The results indicate that this species has a combination of cyclic dormancy and germination requirements that minimizes the risk of germination during periods when the risk of prereproductive mortality is high. Given the short life of the seeds of this species, these mechanisms may be essential for the persistence of the species in the highly unpredictable arid lands of southern Australia

    Daily measurement of organic compounds in ambient particulate matter in Augsburg, Germany: new aspects on aerosol sources and aerosol related health effects

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    Several epidemiological studies have shown that in the human population ambient particulate matter (PM) is associated with adverse health effects. Little is known, however, about the relative effects of aerosol constituents. Since 2002, diurnal samples of ambient PM2.5 were analysed by automated methods for the quantification of particle-associated organic compounds (POC). Data on chemical composition have been investigated in epidemiological and biological effect studies. As a result of these studies, the associations found between PAH concentration and symptoms of myocardial infarction survivors suggest a major influence of combustion sources on cardiovascular health effects. The correlations found between formation of reactive oxygen species and the presence of specific organic compounds suggests an important influence of biomass combustion particles in PM2.5-associated oxidative stress
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