Venus

This is a film review of Venus (2022), directed by Jaume Balagueró

The Convert

This is a film review of The Convert (2023), directed by Lee Tamahori

Werckmeister Harmonies

This is a film review of the 4K restoration of Werckmeister Harmonies (2000), directed by Béla Tarr and Ágnes Hranitzky

Reason (Vivek)

This is a film review of Reason (Vivek) (2018), directed by Anand Patwardhan

Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease

<p>Abstract</p> <p>Background</p> <p>Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by cortico-striatal dysfunction and loss of glutamate uptake. At 7 weeks of age, R6/2 mice, which model an aggressive form of juvenile HD, show a glutamate-uptake deficit in striatum that can be reversed by treatment with ceftriaxone, a β-lactam antibiotic that increases GLT1 expression. Only at advanced ages (> 11 weeks), however, do R6/2 mice show an actual loss of striatal GLT1. Here, we tested whether ceftriaxone can reverse the decline in GLT1 expression that occurs in older R6/2s.</p> <p>Results</p> <p>Western blots were used to assess GLT1 expression in both striatum and cerebral cortex in R6/2 and corresponding wild-type (WT) mice at 9 and 13 weeks of age. Mice were euthanized for immunoblotting 24 hr after five consecutive days of once daily injections (ip) of ceftriaxone (200 mg/kg) or saline vehicle. Despite a significant GLT1 reduction in saline-treated R6/2 mice relative to WT at 13, but not 9, weeks of age, ceftriaxone treatment increased cortical and striatal GLT1 expression relative to saline in all tested mice.</p> <p>Conclusions</p> <p>The ability of ceftriaxone to up-regulate GLT1 in R6/2 mice at an age when GLT1 expression is significantly reduced suggests that the mechanism for increasing GLT1 expression is still functional. Thus, ceftriaxone could be effective in modulating glutamate transmission even in late-stage HD.</p

Penal Agnosis and Historical Denial: Problematising ‘Common Sense’ Understandings of Prison Officers and Violence in Prison

The aim of this chapter is to consider if the much-publicised ‘causal relationship’ between prison officer numbers and prisoner violence is a form of ‘penal agnosis’: the cultural production of penal ignorance (Proctor, Agnotology: a missing term to describe the cultural production of ignorance. In R. Proctor & L. Schiebinger (Eds.), Agnotology: the making and unmaking of ignorance. Stanford: Stanford University Press, 2008). My use of penal agnosis draws directly from the writings of Cohen (States of denial. Cambridge: Polity, 2001) and Mathiesen (Silently silenced. Winchester: Waterside Press, 2004). Silencing techniques deployed in everyday life help to keep people quiet and neutralise criticism. Whilst these are varied, of particular concern here is when an event becomes “isolated in the present” (Mathiesen, Silently silenced. Winchester: Waterside Press, 2004: 42), specifically contemporary media and political discussions of prison officers and prison violence. This chapter provides a theoretical context to the invisibility of historical evidence regarding the deeply embedded harms and violence of penal confinement. It focuses on how the narrative of prison staffing levels is not only time-locked but also how the current understandings of the relationship with violence are derived primarily from the perspective of prison officers. Through critique of this approach an alternative space is opened for thinking differently about how to best respond to the current harms and violence of incarceration

Quantum reflection of ultracold atoms from thin films, graphene, and semiconductor heterostructures

We show that thin dielectric films can be used to enhance the performance of passive atomic mirrors by enabling quantum reflection probabilities of over 90% for atoms incident at velocities ~1 mm/s, achieved in recent experiments. This enhancement is brought about by weakening the Casimir-Polder attraction between the atom and the surface, which induces the quantum reflection. We show that suspended graphene membranes also produce higher quantum reflection probabilities than bulk matter. Temporal changes in the electrical resistance of such membranes, produced as atoms stick to the surface, can be used to monitor the reflection process, non-invasively and in real time. The resistance change allows the reflection probability to be determined purely from electrical measurements without needing to image the reflected atom cloud optically. Finally, we show how perfect atom mirrors may be manufactured from semiconductor heterostructures, which employ an embedded two-dimensional electron gas to tailor the atom-surface interaction and so enhance the reflection by classical means.Comment: 8 pages, 4 figure