210 research outputs found
ΠΠΈΠΊΡΠΎΡΠ²Π΅ΡΠ΄ΠΎΡΡΡ Π²Π°Π»ΠΈΠΊΠΎΠ² ΠΈΠ· Π±ΡΠΎΠ½Π·Ρ ΠΠ-19Π-01, Π½Π°Π½Π΅ΡΠ΅Π½Π½ΡΡ ΠΊΠ°ΠΊ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠ°Ρ ΠΌΡΠ»ΡΠΈΠΌΠΎΠ΄Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΡΡΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΌΡΠ»ΡΡΠΈΠΌΠΎΠ΄Π°Π»ΡΠ½ΡΡ
ΠΏΠΎΠΊΡΡΡΠΈΠΉ ΠΈΠ· ΡΠ°Π·Π½ΠΎΡΠΎΠ΄Π½ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ². ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΌΠΈΠΊΡΠΎΡΠ²Π΅ΡΠ΄ΠΎΡΡΠΈ Π² ΠΏΠΎΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π½Π°ΠΏΠ»Π°Π²Π»Π΅Π½Π½ΡΡ
Π²Π°Π»ΠΈΠΊΠΎΠ² ΠΈΠ· Π°Π»ΡΠΌΠΈΠ½ΠΈΠ΅Π²ΠΎΠΉ Π±ΡΠΎΠ½Π·Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΊΠΎΡΠΎΡΡΠΈ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ²Π΅ΡΠ΄ΠΎΡΡΡ Π² Π½Π°ΠΏΠ»Π°Π²Π»Π΅Π½Π½ΡΡ
Π²Π°Π»ΠΈΠΊΠ°Ρ
.The advantages and the capabilities of laser cladding are analyses for used laser cladding for applying multimodal coatings from heterogeneous metal work materials. Results of microhardness investigations in cross section of cladding tracks from Al-bronze are exhibited. The influence of cladding velocity on microhardness are examined
ΠΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ ΡΡΠ΅Π½ΠΈΠΈ Π½Π΅ΡΠΆΠ°Π²Π΅ΡΡΠ΅ΠΉ ΡΡΠ°Π»ΠΈ Π°ΡΡΡΠ΅Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 12Π₯18Π10Π’ Ρ ΡΠ»ΡΡΡΠ°ΠΌΠ΅Π»ΠΊΠΎΠ·Π΅ΡΠ½ΠΈΡΡΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠΎΠΉ
Π ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ ΡΡΠ΅Π½ΠΈΠΈ ΠΎΠ±ΡΠ΅ΠΌΠ½ΡΡ
ΡΠ»ΡΡΡΠ°ΠΌΠ΅Π»ΠΊΠΎΠ·Π΅ΡΠ½ΠΈΡΡΡΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ². Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»Π°ΡΡ Π½Π΅ΡΠΆΠ°Π²Π΅ΡΡΠ°Ρ ΡΡΠ°Π»Ρ Π°ΡΡΡΠ΅Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 12Π₯18Π10Π’ Ρ ΡΠ»ΡΡΡΠ°ΠΌΠ΅Π»ΠΊΠΎΠ·Π΅ΡΠ½ΠΈΡΡΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠΎΠΉ, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ABC ΠΏΡΠ΅ΡΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠΊΠ°ΡΠΊΠΈ. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΡΡ
ΠΎΠ³ΠΎ ΡΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΠ»ΡΠΆΠ΅Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»Π°ΡΡ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΡ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² Π²ΠΈΠ±ΡΠΎΡΡΠΊΠΎΡΠ΅Π½ΠΈΠΉ ΠΈ Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΌΠΈΡΡΠΈΠΈ
A comparison of the effects of antibiotics, probiotics, synbiotics and prebiotics on the performance and carcass characteristics of broilers
Routine use of the antibiotic flavomycin in broiler production may lead to resistance, and alternative growth promoters are used to enhance performance. Two hundred day-old male Ross 308 broiler chicks were allocated to five dietary supplements included from d 1-42: flavomycin, three possible alternatives, a probiotic, prebiotic and a synbiotic, as well as a control treatment. There were four replicate cages of 10 birds each in each treatment. Compared with the control and antibiotics treatments, the probiotic, prebiotic and synbiotic treatments increased (pβ=β0.001) weight gain (64, 66, 73, 70 and 74\ua0g/d, respectively). The synbiotic treatment reduced (pβ=β0.004) the feed conversion ratio, compared with the control and antibiotic treatments (1.70, 1.84, 1.83, respectively). Compared with the control and antibiotic treatments, the birds fed the synbiotic treatment had greater relative gizzard (+47%) and spleen weights (+115%), and lighter kidneys (-47%). The birds fed the symbiotic treatment also had thinner walls of the caudal gut segments. The prebiotic had the most beneficial effect on cecal microbiota, stimulating aerobic and lactic acid producing bacteria and reducing Escherichia coli bacteria. Enterococci were increased in the antibiotic treatment. We conclude that there were significant performance and health benefits of using prebiotics, probiotics and synbiotics for broilers, rather than antibiotics
Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study
BACKGROUND: The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radiochemotherapy for locally advanced, unresectable non-small cell lung cancer (NSCLC) and to evaluate the efficacy of this regime in a phase II study. METHODS: 33 patients with histologically confirmed NSCLC were enrolled in a combined radiochemotherapy protocol. 29 patients were assessable for evaluation of toxicity and tumor response. Treatment included two cycles of induction chemotherapy with gemcitabine (1200 mg/m(2)) and vinorelbine (30 mg/m(2)) at day 1, 8 and 22, 29 followed by concurrent radiotherapy (2.0 Gy/d; total dose 66.0 Gy) and chemotherapy with gemcitabine every two weeks at day 43, 57 and 71. Radiotherapy planning included [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET) based target volume definition. 10 patients were included in the phase I study with an initial gemcitabine dose of 300 mg/m(2). The dose of gemcitabine was increased in steps of 100 mg/m(2 )until the MTD was realized. RESULTS: MTD was defined for the patient group receiving gemcitabine 500 mg/m(2 )due to grade 2 (next to grade 3) esophagitis in all patients resulting in a mean body weight loss of 5 kg (SD = 1.4 kg), representing 8% of the initial weight. These patients showed persisting dysphagia 3 to 4 weeks after completing radiotherapy. In accordance with expected complications as esophagitis, dysphagia and odynophagia, we defined the MTD at this dose level, although no dose limiting toxicity (DLT) grade 3 was reached. In the phase I/II median follow-up was 15.7 months (4.1 to 42.6 months). The overall response rate after completion of therapy was 64%. The median overall survival was 19.9 (95% CI: [10.1; 29.7]) months for all eligible patients. The median disease-free survival for all patients was 8.7 (95% CI: [2.7; 14.6]) months. CONCLUSION: After induction chemotherapy, the maximum tolerated dose and frequency of gemcitabine was defined at 500 mg/m(2 )every two weeks in three cycles during a maximum of 7 weeks of thoracic radiotherapy for the phase II study. This regimen represents an effective and tolerable therapy in the treatment of NSCLC
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