Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Search for heavy charged long-lived particles in the ATLAS detector in 36.1 fb−1 of proton-proton collision data at √s=13 TeV

A search for heavy charged long-lived particles is performed using a data sample of 36.1     fb − 1 of proton-proton collisions at √ s = 13     TeV collected by the ATLAS experiment at the Large Hadron Collider. The search is based on observables related to ionization energy loss and time of flight, which are sensitive to the velocity of heavy charged particles traveling significantly slower than the speed of light. Multiple search strategies for a wide range of lifetimes, corresponding to path lengths of a few meters, are defined as model independently as possible, by referencing several representative physics cases that yield long-lived particles within supersymmetric models, such as gluinos/squarks ( R -hadrons), charginos and staus. No significant deviations from the expected Standard Model background are observed. Upper limits at 95% confidence level are provided on the production cross sections of long-lived R -hadrons as well as directly pair-produced staus and charginos. These results translate into lower limits on the masses of long-lived gluino, sbottom and stop R -hadrons, as well as staus and charginos of 2000, 1250, 1340, 430, and 1090 GeV, respectively

Measurement of W^±Z production cross sections and gauge boson polarisation in pp collisions at √s=13 TeV with the ATLAS detector

This work is licensed under a Creative Commons Attribution 4.0 International License.This paper presents measurements of ± production cross sections in pp collisions at a centre-of-mass energy of 13 TeV. The data were collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider, and correspond to an integrated luminosity of 36.1 fb−1. The ± candidate events are reconstructed using leptonic decay modes of the gauge bosons into electrons and muons. The measured inclusive cross section in the detector fiducial region for a single leptonic decay mode is fid.±→ℓ′ℓℓ=63.7± 1.0 (stat.)± 2.3 (syst.)± 1.4 (lumi.) fb, reproduced by the next-to-next-to-leading-order Standard Model prediction of 61.5+1.4−1.3 fb. Cross sections for + and − production and their ratio are presented as well as differential cross sections for several kinematic observables. An analysis of angular distributions of leptons from decays of W and Z bosons is performed for the first time in pair-produced events in hadronic collisions, and integrated helicity fractions in the detector fiducial region are measured for the W and Z bosons separately. Of particular interest, the longitudinal helicity fraction of pair-produced vector bosons is also measured

The accretion histories of brightest cluster galaxies from their stellar population gradients

We analyse the spatially-resolved stellar populations of 9 local ($z<0.1$) Brightest Cluster Galaxies (BCGs) observed with VIMOS in IFU mode. Our sample is composed of 7 slow-rotating and 2 fast-rotating BCGs. We do not find a connection between stellar kinematics and stellar populations in this small sample. The BCGs have shallow metallicity gradients (median $\Delta$[Fe/H] $= -0.11\pm0.1$), high central metallicities (median $[$Fe/H]$_{[\alpha/Fe]=0} = 0.13\pm0.07$), and a wide range of central ages (from 5 to 15 Gyr). We propose that the reason for this is diverse evolutionary paths in BCGs. 67 per cent of the sample (6/9) show $\sim 7$ Gyr old central ages, which reflects an active accretion history, and 33 per cent of the sample (3/9) have central ages older than 11 Gyr, which suggest no star formation since $z=2$. The BCGs show similar central stellar populations and stellar population gradients to early-type galaxies of similar mass (M$_{dyn}> 10^{11.3}$M$_{\odot}$) from the ATLAS$^{3D}$ survey (median [Z/H] $= 0.04\pm0.07$, $\Delta$[Z/H] $= -0.19\pm0.1$). However, massive early-type galaxies from ATLAS$^{3D}$ have consistently old ages (median Age $=12.0\pm3.8$Gyr). We also analyse the close massive companion galaxies of two of the BCGs. These galaxies have similar stellar populations to their respective BCGs.Comment: Accepted for publication, MNRAS, March 3, 201

Microbial natural products: molecular blueprints for antitumor drugs

Microbes from two of the three domains of life, the Prokarya, and Eukarya, continue to serve as rich sources of structurally complex chemical scaffolds that have proven to be essential for the development of anticancer therapeutics. This review describes only a handful of exemplary natural products and their derivatives as well as those that have served as elegant blueprints for the development of novel synthetic structures that are either currently in use or in clinical or preclinical trials together with some of their earlier analogs in some cases whose failure to proceed aided in the derivation of later compounds. In every case, a microbe has been either identified as the producer of secondary metabolites or speculated to be involved in the production via symbiotic associations. Finally, rapidly evolving next-generation sequencing technologies have led to the increasing availability of microbial genomes. Relevant examples of genome mining and genetic manipulation are discussed, demonstrating that we have only barely scratched the surface with regards to harnessing the potential of microbes as sources of new pharmaceutical leads/agents or biological probes

Erratum: Search for supersymmetry in final states with two same-sign or three leptons and jets using 36 fb−1 of s = 13 TeV pp collision data with the ATLAS detector (Journal of High Energy Physics, (2017), 2017, 9, (84), 10.1007/JHEP09(2017)084)

One correction is made to the figure 4e of the paper