Multi-learner based recursive supervised training

In this paper, we propose the Multi-Learner Based Recursive Supervised Training (MLRT) algorithm which uses the existing framework of recursive task decomposition, by training the entire dataset, picking out the best learnt patterns, and then repeating the process with the remaining patterns. Instead of having a single learner to classify all datasets during each recursion, an appropriate learner is chosen from a set of three learners, based on the subset of data being trained, thereby avoiding the time overhead associated with the genetic algorithm learner utilized in previous approaches. In this way MLRT seeks to identify the inherent characteristics of the dataset, and utilize it to train the data accurately and efficiently. We observed that empirically, MLRT performs considerably well as compared to RPHP and other systems on benchmark data with 11% improvement in accuracy on the SPAM dataset and comparable performances on the VOWEL and the TWO-SPIRAL problems. In addition, for most datasets, the time taken by MLRT is considerably lower than the other systems with comparable accuracy. Two heuristic versions, MLRT-2 and MLRT-3 are also introduced to improve the efficiency in the system, and to make it more scalable for future updates. The performance in these versions is similar to the original MLRT system

An Experimental and Analytical Approach to Understanding the Dynamic Leaching from Municipal Solid Waste Combustion Residue

This paper describes an experimental technique involving the use of small columns for generating significant quantities of leachate data from municipal solid waste (MSW) solid residues within a relatively short amount of time. Data analysis using the discretized mass balance equations descriptive of the system results in best estimates of governing transport parameters that can, in turn, be used to predict the long-term release of leachable components (As, Cd, Cu, Fe, Ni, Pb, Zn, Ca, Mg, Na, K, Cl, SO4) from the solid matrix. Results indicate that both chemical solubility and physical transport are important factors affecting the flux of contaminants from the solid to the solution phase

A fractional kinetic process describing the intermediate time behaviour of cellular flows

This paper studies the intermediate time behaviour of a small random perturbation of a periodic cellular flow. Our main result shows that on time scales shorter than the diffusive time scale, the limiting behaviour of trajectories that start close enough to cell boundaries is a fractional kinetic process: A Brownian motion time changed by the local time of an independent Brownian motion. Our proof uses the Freidlin-Wentzell framework, and the key step is to establish an analogous averaging principle on shorter time scales. As a consequence of our main theorem, we obtain a homogenization result for the associated advection-diffusion equation. We show that on intermediate time scales the effective equation is a fractional time PDE that arises in modelling anomalous diffusion

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

Journal ArticleThe metabolism of irinotecan (CPT-11) involves sequential activation to SN-38 and detoxification to the pharmacologically inactive SN-38 glucuronide (SN-38G). We have previously demonstrated the role of UGT1A1 enzyme in the glucuronidation of SN-38 and a significant correlation between in vitro glucuronidation of SN-38 and UGT1A1 gene promoter polymorphism. This polymorphism (UGT1A1*28) is characterized by the presence of an additional TA repeat in the TATA sequence of the UGT1A1 promoter, ((TA)7TAA, instead of (TA)6TAA). Here we report the results from a prospective clinical pharmacogenetic study to determine the significance of UGT1A1*28 polymorphism on irinotecan disposition and toxicity in patients with cancer. Twenty patients with solid tumors were treated with a 90 min i.v. infusion of irinotecan (300 mg m−2) once every 3 weeks. The frequency of UGT1A1 genotypes was as follows: 6/6-45%, 6/7-35% and 7/7-20%, with allele frequencies of 0.375 and 0.625 for (TA)7TAA and (TA)6TAA, respectively. Patients with the (TA)7TAA polymorphism had significantly lower SN-38 glucuronidation rates than those with the normal allele (6/6>6/7>7/7, P = 0.001). More severe grades of diarrhea and neutropenia were observed only in patients heterozygous (grade 4 diarrhea, n = 1) or homozygous (grade 3 diarrhea/grade 4 neutropenia, n = 1 and grade 3 neutropenia, n = 1) for the (TA)7TAA sequence. The results suggest that screening for UGT1A1*28 polymorphism may identify patients with lower SN-38 glucuronidation rates and greater susceptibility to irinotecan induced gastrointestinal and bone marrow toxicity

Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates

Lampreys possess two T-like lymphocyte lineages that express either variable lymphocyte receptor (VLR) A or VLRC antigen receptors. VLRA+ and VLRC+ lymphocytes share many similarities with the two principal T-cell lineages of jawed vertebrates expressing the αβ and γδ T-cell receptors (TCRs). During the assembly of VLR genes, several types of genomic cassettes are inserted, in step-wise fashion, into incomplete germ-line genes to generate the mature forms of antigen receptor genes. Unexpectedly, the structurally variable components of VLRA and VLRC receptors often possess partially identical sequences; this phenomenon of module sharing between these two VLR isotypes occurs in both lampreys and hagfishes. By contrast, VLRA and VLRC molecules typically do not share their building blocks with the structurally analogous VLRB receptors that are expressed by B-like lymphocytes. Our studies reveal that VLRA and VLRC germ-line genes are situated in close proximity to each other in the lamprey genome and indicate the interspersed arrangement of isotype-specific and shared genomic donor cassettes; these features may facilitate the shared cassette use. The genomic structure of the VLRA/VLRC locus in lampreys is reminiscent of the interspersed nature of the TCRA/TCRD locus in jawed vertebrates that also allows the sharing of some variable gene segments during the recombinatorial assembly of TCR genes

Head-on infall of two compact objects: Third post-Newtonian Energy Flux

Head-on infall of two compact objects with arbitrary mass ratio is investigated using the multipolar post-Minkowskian approximation method. At the third post-Newtonian order the energy flux, in addition to the instantaneous contributions, also includes hereditary contributions consisting of the gravitational-wave tails, tails-of-tails and the tail-squared terms. The results are given both for infall from infinity and also for infall from a finite distance. These analytical expressions should be useful for the comparison with the high accuracy numerical relativity results within the limit in which post-Newtonian approximations are valid.Comment: 25 pages, 2 figures, This version includes the changes appearing in the Erratum published in Phys. Rev.