National Identification, Endorsement of Acculturation Ideologies and Prejudice: The Impact of the Perceived Threat of Immigration

This paper examines how the perceived threat of immigration affects the links between national identification, endorsement of assimilation or multiculturalism, and prejudice against immigrants in France. One hundred thirty-five French undergraduates completed a questionnaire measuring these factors. Path analysis showed that higher national identification increased perception of immigrants as a threat, which in turn predicted increased endorsement of assimilation for immigrants. The link between endorsement of assimilation and prejudice was not significant. In contrast, lower national identification decreased perception of immigrants as a threat and, in turn, increased endorsement of multiculturalism and reduced levels of prejudice. An alternative model specifying perception of threat as an outcome of preferences for multiculturalism or assimilation did not fit the data well. Results suggest that perceived threat from immigration is the key factor that guides the preferences of the majority group for acculturation ideologies and, through these preferences, shapes intergroup attitudes

The difficulty of recognising less obvious forms of group-based discrimination

Research on perceptions of discrimination has focused on group-based differential treatment that is widely accepted as being illegitimate (e.g., based on race or gender). The present research investigates how individuals interpret less obvious forms of group-based exclusion based on age (Study 1) and vision correction status (Study 2). We propose that individuals will not question the legitimacy of such treatment, unless they are provided with explicit cues to do so. Participants who merely encountered exclusion (baseline control) did not differ from those who were directed to consider the legitimate reasons for this treatment, with respect to perceived legitimacy, felt anger, and collective action intentions. In contrast, individuals who were directed to consider the illegitimate reasons for the exclusion perceived it to be less legitimate, felt more anger, and reported higher collective action intentions. Participants’ own status as potential victims or mere observers of the exclusion criterion did not influence their legitimacy perceptions or felt anger. Results suggest that when confronted with forms of group-based exclusion that are not commonly defined as discrimination, people do not perceive an injustice unless explicitly directed to seek it out

Understanding the relationship between self‐compassion and body dissatisfaction

Body dissatisfaction reflects a person's negative perceptions, thoughts, and feelings regarding their body. Two factors—(1) self‐compassion, a positive attitude of self‐acceptance despite flaws, and (2) gratitude, the capability to notice and appreciate the positive aspects of life—may help to reduce body dissatisfaction. The present research aimed to provide further evidence for the relationship between gratitude, self‐compassion, and body dissatisfaction and test whether meditation focusing on self‐compassion can reduce body dissatisfaction. Two online studies were conducted with samples of adult women recruited in the United Kingdom (N = 342 and 117). Study 1 found that self‐compassion, but not gratitude, significantly predicted lower levels of body dissatisfaction. Study 2 found that participating in a 3‐week meditation program—whether focused on self‐compassion or relaxation—increased self‐compassion over time and reduced body dissatisfaction. Taken together, the findings that regular meditation can bring positive outcomes to women with body dissatisfaction, regardless of the specific focus or content of the meditation

Angry opposition to government redress: when the structurally advantaged perceive themselves as relatively deprived

We examined (structurally advantaged) non-Aborigines' willingness for political action against government redress to (structurally disadvantaged) Aborigines in Australia. We found non-Aborigines opposed to government redress to be high in symbolic racism and to perceive their ingroup as deprived relative to Aborigines. However, only perceived relative deprivation was associated with feelings of group-based anger. In addition, consistent with relative deprivation and emotion theory, it was group-based anger that fully mediated a willingness for political action against government redress. Thus, the specific group-based emotion of anger explained why symbolic racism and relative deprivation promoted a willingness for political action against government redress to a structurally disadvantaged out-group. Theoretical and political implications are discussed

Molecular Analysis of Persistent and Recurrent Barretts Esophagus in the Setting of Endoscopic Therapy.

INTRODUCTION: Early neoplastic progression of Barretts esophagus (BE) is often treated with endoscopic therapy. Although effective, some patients are refractory to therapy or recur after apparent eradication of the BE. The goal of this study was to determine whether genomic alterations within the treated BE may be associated with persistent or recurrent disease. METHODS: We performed DNA sequencing on pre-treatment esophageal samples from 45 patients who were successfully treated by endoscopic therapy and did not recur as well as pre-treatment and post-treatment samples from 40 patients who had persistent neoplasia and 21 patients who had recurrent neoplasia. The genomic alterations were compared between groups. RESULTS: The genomic landscape was similar between all groups. Patients with persistent disease were more likely to have pre-treatment alterations involving the receptor tyrosine kinase pathway ( P = 0.01), amplifications of oncogenes ( P = 0.01), and deletions of tumor suppressor genes ( P = 0.02). These associations were no longer significant after adjusting for patient age and BE length. More than half of patients with persistent (52.5%) or recurrent (57.2%) disease showed pre-treatment and post-treatment samples that shared at least 50% of their driver mutations. DISCUSSION: Pre-treatment samples were genomically similar between those who responded to endoscopic therapy and those who had persistent or recurrent disease, suggesting there is not a strong genomic component to treatment response. Although it was expected to find shared driver mutations in pre-treatment and post-treatment samples in patients with persistent disease, the finding that an equal number of patients with recurrent disease also showed this relation suggests that many recurrences represent undetected minimal residual disease

A T-Cell Engaging Bispecific Antibody With a Tumor-Selective Bivalent Folate Receptor Alpha Binding Arm for the Treatment of Ovarian Cancer

The use of T-cell engagers (TCEs) to treat solid tumors is challenging, and several have been limited by narrow therapeutic windows due to substantial on-target, off-tumor toxicities due to the expression of low levels of target antigens on healthy tissues. Here, we describe TNB-928B, a fully human TCE that has a bivalent binding arm for folate receptor alpha (FRα) to selectively target FRα overexpressing tumor cells while avoiding the lysis of cells with low levels of FRα expression. The bivalent design of the FRα binding arm confers tumor selectivity due to low-affinity but high-avidity binding to high FRα antigen density cells. TNB-928B induces preferential effector T-cell activation, proliferation, and selective cytotoxic activity on high FRα expressing cells while sparing low FRα expressing cells. In addition, TNB-928B induces minimal cytokine release compared to a positive control TCE containing OKT3. Moreover, TNB-928B exhibits substantia

Facilitative parenting and children's social, emotional and behavioural adjustment

Facilitative parenting (FP) supports the development of children’s social and emotional competence and effective peer relationships. Previous research has shown that FP discriminates between children bullied by peers from children who are not bullied, according to reports of teachers. This study investigates the association between FP and children’s social, emotional and behavioral problems, over and above the association with dysfunctional parenting (DP). 215 parents of children aged 5–11 years completed questionnaires about parenting and child behavior, and children and teachers completed measures of child bullying victimization. As predicted, FP accounted for variance in teacher reports of children’s bullying victimization as well as parent reports of children’s social and emotional problems and prosocial behavior better than that accounted for by DP. However for children’s reports of peer victimization the whole-scale DP was a better predictor than FP. Contrary to predictions, FP accounted for variance in conduct problems and hyperactivity better than DP. When analyses were replicated substituting subscales of dysfunctional and FP, a sub-set of FP subscales including Warmth, Supports Friendships, Not Conflicting, Child Communicates and Coaches were correlated with low levels of problems on a broad range of children’s adjustment problems. Parent–child conflict accounted for unique variance in children’s peer victimization (teacher report), peer problems, depression, emotional problems, conduct problems and hyperactivity. The potential relevance of FP as a protective factor for children against a wide range of adjustment problems is discussed

Apology and reparation

Apology and reparations can facilitate the transition from conflict to peace, but the processes of deciding to offer them, determining their content, and deciding whether to accept their terms can themselves give rise to additional conflict. We examine these processes in this chapter, starting with a discussion of the parties involved: victims, perpetrators, group representatives, and third parties. Next, we consider the steps needed to bring about offers of apology and reparations: acknowledgment of illegitimate harm by a perpetrator group, and acknowledgment that restitution is feasible. In the third section we outline the various forms that apology and reparation have taken in intergroup conflict. We then focus on the aftermath of apology and reparation: when are victims and perpetrators likely to support such offers? We conclude that apology and reparation can help resolve conflict, but that they also require careful negotiation. We outline some unanswered questions and directions for future research