フクコウジョウセン キノウ コウシンショウ : ガク シュヨウ ショウコウグン ノ ゲンイン イデンシ サンブツ パラフィブロミン

Primary hyperparathyroidism is characterized by the calcium-insensitive hypersecretion of parathyroid hormone and formation of parathyroid tumors. The disease usually results from a single parathyroid adenoma, but in a minority of cases is a part of hereditary syndromes; multiple endocrine neoplasia types 1 and 2A, familial isolated hyperparathyroidism, and hyperparathyroidism-jaw tumor (HPT-JT) syndrome. HPT-JT syndrome is characterized by parathyroid tumors, fibro-osseous lesions of the mandible and maxilla, and renal cysts and tumors. The gene whose inactivation is directly associated with the pathogenesis of HPT-JT syndrome has been identified as the tumor suppressor gene HRPT2. Parafibromin, a 531-amino acid protein encoded by HRPT2, has partial homology with the yeast Cdc73, a component of the RNA polymerase II-associated Paf1 complex including Paf1, Leo1, Ctr9, and Rtf1. Parafibromin binds to RNA polymerase II as a part of human Paf1 complex together with human orthologs of Paf1, Leo1, Ctr9. Human Paf1 complex appears to be involved in transcription elongation. Parafibromin has antiproliferative activity by inhibition of cyclin D1 and c-myc proto-oncoprotein. Whereas, we recently demonstrated that parafibromin acts as a positive regulator of cell growth like an oncoprotein in the presence of SV40 large T antigen, indicating parafibroimin has potentially ambivalent functions in tumorigenesis. This review focuses on the functions of parafibromin and human Paf1 complex, providing an insight into its potential involvement in the development of cancer

Large scale analysis of interactive behaviors of bubbles and particles in a liquid by a coupled immersed boundary and vof technique

A new approach for direct numerical simulation of three-phase (gas-liquid-solid) flows is proposed. Implementation of moving rigid surface in a fluid is based on an immersed boundary/solid-object method method developed by the present authors, and gas-liquid interface is captured by volume-of-fluid (VOF) method with an interface reconstruction scheme. The proposed coupling technique enables simulation of flow structures induced by both bubble and particle of comparable sizes, including the flow pattern around the gas-liquid and solid-liquid interfaces. In a suspension of 1024 solid particles and a bubble, some typical behaviours of bubble-particle interaction and liquid flow pattern are captured. The detailed analysis on the motion of the falling particles suggests that the particle rotation is strongly influenced by the behaviours of the rising bubble, giving rise a snap reversal of the rotating directions of the particles due to the flow induced by the bubble.This is a pre-copyedited, author-produced PDF of an article accepted for publication in Multiphase Science and Technology following peer review