Jishindo ni taisuru kenchikubutsu no herusu monitaringu no tame no sokan hen\u27i keisoku ni kansuru kenkyu

制度:新 ; 報告番号:甲3342号 ; 学位の種類:博士(工学) ; 授与年月日:2011/2/25 ; 早大学位記番号:新564

Measuring Relative-Story Displacement and Local Inclination Angle Using Multiple Position-Sensitive Detectors

We propose a novel sensor system for monitoring the structural health of a building. The system optically measures the relative-story displacement during earthquakes for detecting any deformations of building elements. The sensor unit is composed of three position sensitive detectors (PSDs) and lenses capable of measuring the relative-story displacement precisely, even if the PSD unit was inclined in response to the seismic vibration. For verification, laboratory tests were carried out using an Xθ-stage and a shaking table. The static experiment verified that the sensor could measure the local inclination angle as well as the lateral displacement. The dynamic experiment revealed that the accuracy of the sensor was 150 μm in the relative-displacement measurement and 100 μrad in the inclination angle measurement. These results indicate that the proposed sensor system has sufficient accuracy for the measurement of relative-story displacement in response to the seismic vibration

Measuring Relative-Story Displacement and Local Inclination Angle Using Multiple Position-Sensitive Detectors

We propose a novel sensor system for monitoring the structural health of a building. The system optically measures the relative-story displacement during earthquakes for detecting any deformations of building elements. The sensor unit is composed of three position sensitive detectors (PSDs) and lenses capable of measuring the relative-story displacement precisely, even if the PSD unit was inclined in response to the seismic vibration. For verification, laboratory tests were carried out using an Xθ-stage and a shaking table. The static experiment verified that the sensor could measure the local inclination angle as well as the lateral displacement. The dynamic experiment revealed that the accuracy of the sensor was 150 µm in the relative-displacement measurement and 100 µrad in the inclination angle measurement. These results indicate that the proposed sensor system has sufficient accuracy for the measurement of relative-story displacement in response to the seismic vibration

Ultrasonic Lateral Displacement Sensor for Health Monitoring in Seismically Isolated Buildings

An ultrasonic lateral displacement sensor utilizing air-coupled ultrasound transducers is proposed. The normally-distributed far field of an ultrasound transducer in a lateral direction is taken advantage of for measuring lateral displacement. The measurement system is composed of several air-coupled ultrasound transducers as a receiver and several transmitters. The transmitters are immobilized at a fixed point, whereas the receiver set-up is separately arranged on the opposite side. In order to improve measurement accuracy, a correction method that utilizes polynomial approximation is introduced. The difference between the corrected lateral displacement and the reference displacement is estimated to be 0.2 mm at maximum for the two transmitters system. A good responsiveness is demonstrated by conducting a dynamic response experiment. When five transmitters are arranged, their measurement range is easily extended up to ±60 mm with an accuracy of 0.7 mm. In both cases, the fluctuations to the measurement ranges show less than 1%. These results indicate that the developed sensor system is useful for measuring relative lateral displacement of a seismically isolated building in the field of structural health monitoring

Measuring Liquid-Level Utilizing Wedge Wave

A new technique for measuring liquid-level utilizing wedge wave is presented and demonstrated through FEM simulation and a corresponding experiment. The velocities of wedge waves in the air and the water, and the sensitivities for the measurement, are compared with the simulation and the results obtained in the experiments. Combining the simulation and the measurement theory, it is verified that the foundation framework for the methods is available. The liquid-level sensing is carried out using the aluminum waveguide with a 30° wedge in the water. The liquid-level is proportional to the traveling time of the mode 1 wedge wave. The standard deviations and the uncertainties of the measurement are 0.65 mm and 0.21 mm using interface echo, and 0.39 mm and 0.12 mm utilized by end echo, which are smaller than the industry standard of 1.5 mm. The measurement resolutions are 7.68 μm using the interface echo, which is the smallest among all the guided acoustic wave-based liquid-level sensing

DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies

DPP8/9 inhibition induces either pyroptotic or apoptotic cell death in hematological malignancies. We previously reported that treatment with the DPP8/9 inhibitor 1G244 resulted in apoptotic cell death in myeloma, and our current study further evaluates the mechanism of action of 1G244 in different blood cancer cell lines. Specifically, 1G244 inhibited DPP9 to induce GSDMD-mediated-pyroptosis at low concentrations and inhibited DPP8 to cause caspase-3-mediated-apoptosis at high concentrations. HCK expression is necessary to induce susceptibility to pyroptosis but does not participate in the induction of apoptosis. To further characterize this DPP8-dependent broad-spectrum apoptosis induction effect, we evaluated the potential antineoplastic role for an analog of 1G244 with higher DPP8 selectivity, tominostat (also known as 12 m). In vitro studies demonstrated that the cytotoxic effect of 1G244 at high concentrations was enhanced in tominostat. Meanwhile, in vivo work showed tominostat exhibited antitumor activity that was more effective on a cell line sensitive to 1G244, and at higher doses, it was also effective on a cell line resistant to 1G244. Importantly, the weight loss morbidity associated with increasing doses of 1G244 was not observed with tominostat. These results suggest the possible development of novel drugs with antineoplastic activity against selected hematological malignancies by refining and increasing the DPP8 selectivity of tominostat