1 research outputs found
POSSIBILITIES OF POSITRON-EMISSION TOMOGRAPHY IN DIAGNOSIS OF MALIGNANT BRAIN TUMORS (Literature Review)
Π Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π½Π° Π΄ΠΎΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΡΡΠ°ΠΏΠ°Ρ
ΠΏΠΎΠ·ΠΈΡΡΠΎΠ½Π½ΠΎ-ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ (ΠΠΠ’) ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΌΡΠΌ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π»ΡΡΠ΅Π²ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ, ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΡΡΡΡΠΊΡΡΡΡ ΠΈ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ (ΠΊΠ°ΠΊ Π² ΡΠ»ΡΡΠ°Π΅ ΠΠ Π’ β ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ ΠΈ ΠΠ‘ΠΠ’ β ΠΌΡΠ»ΡΡΠΈΡΠΏΠΈΡΠ°Π»ΡΠ½Π°Ρ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ), Π½ΠΎ ΡΠ°ΠΊΠΆΠ΅ ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² Π½ΠΈΡ
, ΡΡΠΎ Π΄Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°ΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡ Π½Π° ΡΠ°ΠΌΡΡ
ΡΠ°Π½Π½ΠΈΡ
ΡΡΠΎΠΊΠ°Ρ
, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π·Π³ΡΠ°Π½ΠΈΡΠΈΡΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½Π½ΡΠΉ ΡΠΎΡΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΎΡ ΠΏΡΠ΅Π²Π΄ΠΎΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΠΈ Π½Π° ΡΠΎΠ½Π΅ ΠΏΠΎΡΡΠ»ΡΡΠ΅Π²ΡΡ
Π½Π΅ΠΊΡΠΎΠ·ΠΎΠ². Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΠΈΡΠΎΠΊΠΈΠΉ ΡΠΏΠ΅ΠΊΡΡ ΡΠ°Π΄ΠΈΠΎΡΠ°ΡΠΌΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
Π΄Π»Ρ ΠΠΠ’, ΠΏΡΠΈ ΡΡΠΎΠΌ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π½Π°Ρ
ΠΎΠ΄ΡΡ 18F-Π€ΠΠ ΠΈ 11Π‘-ΠΠΠ’ (18F-ΡΡΠΎΡΠ΄ΠΈΠΎΠΊΡΠΈΠ³Π»ΡΠΊΠΎΠ·Π° ΠΈ 11Π‘-ΠΌΠ΅ΡΠΈΠΎΠ½ΠΈΠ½). Π ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΌ ΠΎΠ±Π·ΠΎΡΠ΅ ΠΎΠΏΠΈΡΡΠ²Π°Π΅ΡΡΡ ΠΌΠ΅ΡΡΠΎ ΠΏΠΎΠ·ΠΈΡΡΠΎΠ½Π½ΠΎ-ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ Π½Π° ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠ°Π·Π½ΡΡ
ΡΠ°Π΄ΠΈΠΎΡΠ°ΡΠΌΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΏΡΠΈ ΡΠ°Π·Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, ΡΡΠΎ ΠΈΠΌΠ΅Π΅Ρ Π²Π°ΠΆΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈ Π²ΡΠ΅ Π±ΠΎΠ»Π΅Π΅ ΡΠΈΡΠΎΠΊΠΎΠΌ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ.In the diagnosis of neoplasms at the preoperative and postoperative stages, positron emission tomography (PET) is the most informative method of radiation diagnosis, the main advantage of which is the determination of not only the structure and localization of tumors (as in the case of MRI and MSCT), but also the metabolic processes in them, which makes it possible to diagnose the tumor process at the earliest possible time, and also to delimit the continued growth of the tumor from pseudo-progression against the background of post-radiation necrosis. Nowadays, there is a fairly wide range of radiopharmaceuticals used for PET, with 18F-FDG and 11C-MET (18F-fluorodeoxyglucose and 11C-methionine) being the most clinically important. This review describes the location of positron emission tomography in the diagnosis of malignant brain tumors, and also points out the sensitivity of various radiopharmaceuticals with different brain pathologies, which is important with the ever wider introduction of this diagnostic method into clinical practice