6 research outputs found
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- Abo‐Auda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- Arias‐Mendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- Biering‐Sørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
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- Brito Dulce
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- Bruno Marco Raul Litvak
- Bu Peili
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- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
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- Caccavo Alberto
- Canesin Manoel
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- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
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- Chen Jiyan
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- Chung Eugene
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- Corbalan Ramon
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- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- Crespo‐Leiro Maria G.
- Cruz Kimberly
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- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
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- Diaz Rafael
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- Doi Masayuki
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- Drexel Heinz
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- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
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- Eberly Arthur
- Ebner Christian
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- Vandekerckhove Hans
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- Vasilyeva Larysa
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- Vazquez Eduardo Salcido
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- Videbaek Lars
- Vidotti Maria Helena
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- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
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- Voevoda Mikhail
- Vogel Daniel
- Voicu Olga‐Cristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- Wozakowska‐Kaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594).
Conclusions:
GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
The utility of CD200 expression and modified Matutes score in the diagnostic differentiation of mantle cell lymphoma and chronic lymphocytic leukemia using flow cytometry
- Publication venue
- 'Informa UK Limited'
- Publication date
- 24/09/2019
- Field of study
A rare case of Candida parapsilosis endocarditis in a young healthy woman – case report
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- 'Springer Science and Business Media LLC'
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Prediction of general medical admission length of stay with natural language processing and deep learning: a pilot study
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- A Esteva
- A Wong
- C Mazzali
- C-J Lin
- David K. Menon
- H Maharlou
- Ivana Chim
- J Waring
- JAM Sidey-Gibbons
- Jim Jannes
- Joy Cheng
- JT Senders
- L Chambless
- L Turgeman
- M Chary
- M Elbattah
- M-T Chuang
- N Schwartz
- O Khosravizadeh
- PN Ramkumar
- S Bacchi
- Samuel Gluck
- Simon Koblar
- SM Navarro
- Stephen Bacchi
- T Daghistani
- T Goto
- T Hollon
- Timothy Kleinig
- Toby Gilbert
- TY Yong
- WJ Youden
- Y Liu
- Yiran Tan
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
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- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
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- Claudio Cavallini
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- Dmitriy Belenkiy
- Dmitry Dronov
- Dmytro Reshotko
- Domenico Bonaduce
- Domingo Andres Pascual Figal
- Dongye Li
- Donna Mancini
- Dora Ines Molina de Salazar
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- Erik Hajko
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- Ertugrul Okuyan
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- Eva Goncalvesova
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- Filipa Almeida
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- Georgi Todorov
- Georgiy Dzyak
- Georgy Arbolishvili
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- Gerardus Linssen
- Gerasimos Filippatos
- Gerhard Poelzl
- Geza Lupkovics
- Giancarlo Piovaccari
- Gianfranco Sinagra
- Gianpiero Perna
- Gilmar Reis
- Gintare Sakalyte
- Giovanni Geronilla
- Giovanni Quinto Villani
- Giuseppe Ambrosio
- Giuseppe Musumeci
- Glenn Hamroff
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- Guillermo Antonio Llamas Esperon
- Guoqin Chen
- Gurinder Grewal
- Gurusher Panjrath
- Gustavo Francisco Mendez Machado
- Guy Proulx
- Gyula Szasz
- Hakima Bourhaial
- Hal Skopicki
- Hamish Hart
- Hanbin Cui
- Hans Vandekerckhove
- Hans-Dirk Duengen
- Haralambos Karvounis
- Harinder Gogia
- Harukazu Iseki
- Hassan Ibrahim
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- Henning Ebelt
- Henricus Van Kesteren
- Henrik Wiggers
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- Henry Ooi
- Hernan Emilio Francisco Polo Friz
- Hideki Ueno
- Hideo Izawa
- Hideo Kawakami
- Hideyuki Tsuboi
- Hiroaki Kitaoka
- Hiroaki Kiyokawa
- Hiroki Uehara
- Hiroshi Asano
- Hiroshi Domae
- Hiroshi Ito
- Hiroshi Meno
- Hiroshi Sugino
- Hiroshi Takaishi
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- Hisashi Kai
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- Igor Vakaliuk
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- Ioannis Styliadis
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- Irina Osipova
- Irina Semenova
- Iurii Rudyk
- Ivan Goncharov
- Ivan Majercak
- Ivana Kellnerova
- Ivaylo Vasilev
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- Ivo Podpera
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- J Russell Strader
- Jacob Eifer Moller
- Jacob Van Eck
- Jadwiga Nessler
- Jagadeesh Ganji
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- Jana Lukacova
- Janka Skrobakova
- Janos Tomcsanyi
- Janusz Spyra
- Jaroslaw Drozdz
- Jaroslaw Trebacz
- Jason C Legg
- Jason Glover
- Jasper Trevelyan
- Javed Butler
- Javier Segovia Cubero
- Javier Vasallo
- Jean Etienne Ricci
- Jean-Louis Georges
- Jean-Marie Lefebvre
- Jean-Michel Tartiere
- Jean-Noel Trochu
- Jean-Pierre Gueffet
- Jeffrey Martindale
- Jelena Celutkiene
- Jenica N Upshaw
- Jennifer Cook
- Jens Taggeselle
- Jeremy Cox
- Jeroen Schaap
- Jerzy Kopaczewski
- Jianjun Li
- Jindrich Spinar
- Jing Li
- Jing Yan
- Jinguo Zhang
- Jiri Krupicka
- Jiyan Chen
- Joao Carlos Braga
- Joaquin Martinez-Arraras
- Johanna Contreras
- Johannes Remmen
- John Amerena
- John Andrew Morrow
- John Atherton
- John Beltrame
- John Boehmer
- John Cleland
- John Collins
- John Corbelli
- John French
- John Groarke
- John Harris
- John Heitner
- John J V McMurray
- John Kao
- John Mignone
- John Murray
- John Parissis
- John van Hal
- Jolita Badariene
- Jonathan Howlett
- Jooyoung Shin
- Jorge Cheirif
- Jorge Leonardo Cobos Segarra
- Jorge Roberto Aiub
- Jorgen Jeppesen
- Jose Alfredo Pagola Carrasco
- Jose Augusto Ribas Fortes
- Jose Cardona
- Jose Francisco Saraiva
- Jose Luis Accini Mendoza
- Jose Luis Arenas Leon
- Jose Luis Lambert Rodriguez
- Jose Maria Arizon Del Prado
- Jose Ramon Gonzalez Juanatey
- Joseph Massaro
- Joseph Radojevic
- Joseph Rahman
- Joshua Asubiaro
- Jozef Gonsorcik
- Juan Francisco Delgado Jimenez
- Juan Jose Gomez Doblas
- Juan Londono
- Juan Luis Bonilla Palomas
- Julian Alonso Coronel Arroyo
- Julian Javier
- Juliano Cardoso
- Julio Eduardo Nuñez Villota
- Julio Ibañez
- Julio Tallet
- Jun Tanabe
- Junji Kanda
- Justin Ezekowitz
- Justin Taylor
- Kabir Yousuf
- Kahraman Cosansu
- Kalman Toth
- Kamil Zeman
- Kaoru Okishige
- Karel Peterka
- Karel Sochor
- Karen P Alexander
- Karen Sliwa
- Karl Dujardin
- Karl Heilman
- Katalin Bezzegh
- Katerina Naka
- Katsunori Kawamitsu
- Kazuhisa Mitsuo
- Keiji Ujino
- Keijiro Saku
- Keisuke Kida
- Keith Aaronson
- Keith Friedman
- Kenji Ando
- Kenji Onoue
- Kenneth Wong
- Kenshi Fujii
- Kentaro Nakamura
- Keyur Shah
- Kimberly Cruz
- Kimiaki Nagase
- Kirkwood Adams
- Klemens Ablasser
- Kodangudi Ramanathan
- Koichi Node
- Koichiro Sugimura
- Konstantin Zrazhevskiy
- Konstantinos Tsioufis
- Kotaro Numaguchi
- Kouji Kajinami
- Krzysztof Cymerman
- Kumiko Nakayama
- Kunihiko Makino
- Kurt Boman
- Kurt Huber
- Kurtz C. E. GALACTIC-HF Investigators: John R Teerlink
- Ladislav Busak
- Lana Tsao
- Lanfear D. E.
- Larry Allen
- Lars Videbaek
- Larysa Mishchenko
- Larysa Vasilyeva
- Laszlo Mark
- Laszlo Nagy
- Laura Jordan Martinez
- Laurie Letarte
- Lawrence Galitz
- Lawrence J Lesko
- Legg J. C.
- Leighton Kearney
- Lenka Spinarova
- Leonard Pianko
- Leonardo Macias
- Leonardo Novaretto
- Leonid Pimenov
- Leonid Rudenko
- Leonid Voronkov
- Leopoldo Soares Piegas
- Lesley Burgess
- Lesya Rasputina
- Li J.
- Libor Nechvatal
- Lidia Ana Zytynski Moura
- Lidia Pawlowicz
- Lilia Luz Lobo Marquez
- Lilia Nigro Maia
- Lilia Schiavi
- Liliana Nicolosi
- Lily Zhang
- Lisa Mielniczuk
- Liudmyla Alieksieieva
- Lixin Jiang
- Llyod Stahl
- Lokesh Chandra
- Louis Van Zyl
- Luanda Grazette
- Lubomir Antalik
- Luc Pierard
- Lucie Sharpsten
- Lucyna Lenartowska
- Luis Almenar Bonet
- Luis Beck da Silva Neto
- Luis de la Fuente Galan
- Luis Eduardo Echeverria
- Luis Eduardo Echeverria
- Luis Horacio Atehortua Lopez
- Luis Martinez
- Luis Oliveira
- Luis Santos
- Lund M.
- Lutfu Bekar
- Lutz Frankenstein
- Macdonald P.
- Maciej Zabowka
- Madhusudhan Pamganamamula
- Magnus Peterson
- Mahazarin Ginwalla
- Makoto Nakahama
- Makoto Usui
- Malgorzata Konieczynska
- Malgorzata Lelonek
- Malik F. I.
- Mamoru Manita
- Manoel Canesin
- Manohara Senaratne
- Manuel Bouza
- Manuel Eduardo Rodriguez Venegas
- Manuel Martinez-Selles D Oliveira Soares
- Manuel Odin De Los Rios Ibarra
- Marat Ezhov
- Marc Simon
- Marcelo Alejandro Garrido
- Marcin Szczasny
- Marco Metra
- Marcos Amuchastegui
- Marcos Raul Litvak Bruno
- Marcus Mittag
- Marcus Sandri
- Marcus Stoddard
- Marcus Vinicius Simoes
- Mareev V.
- Marek Houra
- Marek Piatek
- Margarita Gertrudis Vejar Jalaf
- Maria Alexandra Arias Mendoza
- Maria Cristina Schnettler Cid
- Maria Dorobantu
- Maria Frigerio
- Maria Generosa Crespo Leiro
- Maria Helena Vidotti
- Maria Leonor Parody
- Maria Sanali Paiva
- Maria Sitnikova
- Maria Teresa Blasco Peiro
- Maria Tzekova
- Mariel Rivero
- Mariela Rasmussen
- Marilena Renata Spiridon
- Mario Vega
- Mario Villoch
- Mario Yanez Hidalgo
- Marisa Crespo Leiro
- Marisa Orgera
- Mariusz Kafara
- Mark Abelson
- Mark Ramos
- Mark Smith
- Mark Zucker
- Martin Berk
- Martin Huelsmann
- Martin LeWinter
- Marvin A Konstam
- Mary Lynch
- Masahiro Ishikawa
- Masahiro Suzuki
- Masaki Yoshikawa
- Masanori Asakura
- Masaru Yuge
- Masayoshi Ajioka
- Masayuki Doi
- Masuki Mori
- Mateusz Sidor
- Mathue Baker
- Matt Wilkett
- Matteo Di Biase
- Matthew Janik
- Matthew Wheeler
- Matthias Dupont
- Maurizio Volterrani
- Mayanna Lund
- McMurray J. J. V.
- Mehmet Birhan Yilmaz
- Mehmet Birhan Yilmaz
- Mehmet Duzenli
- Mehrdad Ariani
- Melchor Alpizar Salazar
- Melvin Martinez-Castrillon
- Mesut Demir
- Metra M.
- Michael Boehm
- Michael Böhm
- Michael Felker G.
- Michael Hartleib
- Michael Koren
- Michael Kwan
- Michael Magro
- Michael Miyamoto
- Michael Pham
- Michael Radin
- Michal Cepelak
- Michel Galinier
- Michel Ovize
- Michele Hamilton
- Michele Senni
- Miguel Alfredo Moncada Corredor
- Miguel Angel Hominal
- Miguel Urina Triana
- Mikhail Kotelnikov
- Mikhail Voevoda
- Milan Gupta
- Mio Ebato
- Mircea Ioachim Popescu
- Mirta Diez
- Mitsuhiro Shimomura
- Mitsuru Tsujimoto
- Mitsutaka Yamamoto
- Mohammad Abuannadi
- Mohan Babapulle
- Momomura S.
- Monica Lopez Pareja
- Mori Krantz
- Mukesh Sharma
- Munir Janmohamed
- Muriel Salvat
- Mustafa Tuncer
- Mustafa Vural
- Mykola Rishko
- Mykola Stanislavchuk
- Nabil Dib
- Nadia Giannetti
- Naeem Tahirkheli
- Nampalli Vijay
- Nancy Sweitzer
- Nandini Nair
- Nandkishore Ranadive
- Naoki Sato
- Naoki Watanabe
- Narimon Honarpour
- Naseem Jaffrani
- Nasir Sulemanjee
- Natale Daniele Brunetti
- Nataliya Shilkina
- Nathan Mewton
- Natsuki Takahashi
- Navid Kazemi
- Navin Rajagopalan
- Neil Farris
- Neil Lewis
- Nicholas Kondo
- Nicole Lohr
- Niels Gadsboll
- Niels Menck
- Nikolay Tarasov
- Nishant Shah
- Nobuhide Miyamoto
- Nobuyuki Komiyama
- Noemi Nyolczas
- Nolan Mayer
- Norberto Duda
- Noriaki Takama
- Noriaki Utsu
- Norman Lepor
- Nqoba Tsabedze
- Nyda Fourie
- O'Meara E.
- Okan Onur Turgut
- Ole Nyvad
- Oleg Solovev
- Oleksandr Karpenko
- Oleksandr Parkhomenko
- Oleksandr Prokhorov
- Oleksii Korzh
- Oleksii Kulynych
- Olga Barbarash
- Olga Bolshakova
- Olga-Cristina Voicu
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- Ondrej Jerabek
- Oscar Alberto Gomez Vilamajo
- Oscar Alejandro Salomone
- Oscar Romano Montana
- Oswaldo Greco
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- Otavio Coelho Filho
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- Pascalle van Huysduynen-Monraats
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- Patrick Donnelly
- Patrizio Lancellotti
- Paul Kalra
- Paulo Ernesto Leaes
- Paulo Roberto Ferreira Rossi
- Pavel Koleckar
- Pawel Balsam
- Pawel Miekus
- Pedro Gabriel Melo de Barros E Silva
- Pedro Monteiro
- Pedro Morais Sarmento
- Pedro Pimentel Filho
- Peili Bu
- Peter Andreka
- Peter Carson
- Peter Fulop
- Peter Kaiser-Nielsen
- Peter Macdonald
- Peter Rahko
- Peter Siostrzonek
- Peter Wodlin
- Petr Tyl
- Philip Haines
- Philip Keeling
- Philippe Berdague
- Philippe Meyer
- Piergiuseppe Agostoni
- Piers Clifford
- Ping Yang
- Piotr Berkowski
- Piotr Jankowski
- Piotr Ponikowski
- Ponikowski P.
- Pradeep Singh
- Pranas Serpytis
- Pratik Desai
- Priya Pillutla
- Qinghua Han
- Radim Kryza
- Rafael Diaz
- Rafael Díaz
- Rafael Luiz Rech
- Rafik Abadier
- Raja Chehayeb
- Rajat Barua
- Rajendra H Metha
- Rajendran Moodley
- Rajesh Sharma
- Rakesh Bhargava
- Ralf Westenfeld
- Rami Alharethi
- Ramires F. J. A.
- Ramon Bover Freire
- Ramon Corbalan
- Ramon Corbalan Herreros
- Randall Starling
- Raul Reyes Araiza
- Raveen Arora
- Ravi Bhagwat
- Renato Chaves
- Renato Lopes
- Ricardo Alfonso Leon de la Fuente
- Ricardo Garcia Gonzalez
- Richard Fremont
- Richard Gilmore
- Richard Isnard
- Richard Katz
- Rimvydas Slapikas
- Rita Kazinczy
- Robert Buynak
- Robert Gianfagna
- Robert Kowalski
- Robert McKelvie
- Robert Mohapatra
- Robert Schnitzler
- Robert Stewart
- Robert W Harrison
- Robert W McGarrah
- Roberta Bogaev
- Roberta Rossini
- Roberto Colque
- Robin Mathews
- Robin Weir
- Rodolfo Andres Ahuad Guerrero
- Rodrigo Botero Lopez
- Rodrigo da Silva
- Rodrigo Julio Cerci
- Roger Hullin
- Roman Margoczy
- Roman Myasnikov
- Roman Pfister
- Roman Stets
- Ronald Bourgeois
- Ronald Fernando
- Ronald Zolty
- Rosario Santa Fe
- Rostislav Polasek
- Ruben Omar Garcia Duran
- Rudolf Smik
- Rudolf Spacek
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- Salvador Rassi
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- Shahid Mahmood
- Shamaila Aslam
- Sharpsten L.
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- Sliwa K.
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- Susan Joseph
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- Svetlana Dovgolis
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- Syed Hasni
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- Takahiro Okumura
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- Takeshi Serikawa
- Takeshi Yoshida
- Tamas Forster
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- Tianfa Li
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- Timothy Doyle
- Tina Sichrovsky
- Tiziano Moccetti
- Tjeerd Römer
- Tokushi Koga
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- Tomas Brabec
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- Tor Biering-Sørensen
- Toru Kubota
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- Toshio Kasai
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- Ulf Dahlstrom
- Umit Guray
- Uwe Zeymer
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- Viviane Nguyen
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- Vladimir Nosov
- Vladimir Rafalskiy
- Vladimir Salukhov
- Vladislav Mitrokhin
- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
- Walter Abhayaratna
- Walter Droogne
- Walter Hermans
- Wataru Shimizu
- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
- Wilder Castaño Osorio
- William Anderson
- William Herzog
- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
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- Baracioli Luciano
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- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
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- Behnke Thomas
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- Bertrand Olivier
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- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
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- Bolshoun David
- Bonansea Teresa C
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- Carrasco Jose P
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- Chehayeb Raja
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- Chen Jersey
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- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
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- Chiang Chern
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- Green Sandy
- Greenberg Gabriel
- Grena Paul
- Greschik István
- Gring Christian
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- Guedes Antoine
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- Guillen Mario
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- Haro Jaime M
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- HASH(0x55aa09b7f480)
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- Hofseth Ola D
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- Manshadi Ramin
- Mansour Samer
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- Mantserova Olga
- Manzur Fernando
- Mar Guang-Yuan
- Marcucci Rossella
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- Markov Dimitar
- Markov Valentin
- Maron David
- Martinez Guillermo R
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- Nadar Venkatesh
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- Nagy András C
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- Nakamura Toshihiro
- Nakhle Samer
- Nam Chang-Wook
- Nanji Alykhan
- Napoli Mark
- Nascimento Carlos
- Navarro Manuel J
- Nechaeva Galina
- Negron Sandra
- Neuenschwander Fernando
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- Nicolau José C
- Niedbal-Yahfouf Izabela
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- Ongen Zeki
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- Opolski Grzegorz
- Oral Ivo
- Ortiz Antonio F
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- Raisinghani Ajit
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- Ramos López Gabriel A
- Randeva Harpal S.
- Range Gregoire
- Ranjith Naresh
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- Rassi Nelson
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- Ray Kausik K
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- Vallejo Gregorio S
- van de Wal Ruud
- van den Heuvel Christian
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- Wojcik Ronald
- Wojnowski Lukasz
- Wolzt Michael
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- Wong Michelle
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- Woolf Kevin
- Worthley Matthew
- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk