33 research outputs found
Effect of Origanum heracleoticum L. essential oil on food-borne Penicillium aurantiogriseum and Penicilium chrysogenum isolates
Molds are ubiquitously distributed in nature and their spores can be found in the atmosphere even at high altitudes. The difficulty of controlling these undesirable molds, as well as the growing interest of the consumers in natural products, have been forcing the industry to find new alternatives for food preservation. The modern trends in nutrition suggest the limitation of synthetic food additives or substitution with natural ones. Aromatic herbs are probably the most important source of natural antimicrobial agents. Origanum heracleoticum L. essential oil has been known as an interesting source of antimicrobial compounds to be applied in food preservation. In the this work, we have investigated the effect of essential oil obtained from O. heracleoticum on growth of six isolates of Penicillium aurantiogriseum and four isolates of Penicillium chrysogenum isolated from meat plant for traditional Petrovacka sausage (PetrovskĆ” klobĆ”sa) production. The findings reveal that the essential oil of O. heracleoticum provides inhibition of all of fungal isolates tested. O. heracleoticum L. essential oil exhibited higher antifungal activity against the isolates of P. chrysogenum than the isolates of P. aurantiogriseum. O. heracleoticum essential oil showed a MIC value ranging from 25 to 100 Ī¼L/mL. The fungi cultivated in the medium with higher concentration of essential oil showed certain morphological changes. The alterations included lack of sporulation and loss of pigmentation
Povezanost sniženoga salivarnog melatonina i naruÅ”ene kvalitete života u bolesnika s kroniÄnom spontanom urtikarijom - probno istraživanje
Chronic spontaneous urticaria (CSU) is a dermatological disorder accompanied
by itching that greatly affects the quality of life and quality of sleep. Therefore, it is assumed that
CSU patients consequently experience reduced melatonin secretion and lower values of serum or
salivary melatonin. This pilot study included 20 patients with CSU (chronic urticaria of unknown
etiology that lasts for more than 6 weeks) and 10 healthy controls. All subjects were examined by
a dermatovenereologist-allergist, as well as an oral pathologist, to exclude oral pathological conditions.
Salivary melatonin levels were determined by ELISA and all subjects completed a standardized
Dermatology Life Quality Index questionnaire and Pittsburgh Sleep Quality Index on the
same day they gave a saliva sample for analysis. According to our results, 86% of CSU patients had
decreased values of salivary melatonin, and lower salivary melatonin values significantly correlated
with a reduced quality of life in CSU patients. This study was the first to analyze melatonin in CSU
patients, also suggesting a possible new therapeutic option for the treatment of CSU.KroniÄna spontana urtikarija (KSU) je bolest kože praÄena intenzivnim subjektivnim osjeÄajem svrbeža koji snažno
utjeÄe na kvalitetu života i kvalitetu spavanja bolesnika. Pretpostavka je da bolesnici s KSU-om posljediÄno imaju smanjeno
luÄenje melatonina, kao i niže vrijednosti melatonina u serumu ili slini. Ovo probno istraživanje ukljuÄilo je 20 bolesnika s
KSU-om (urtikarija koja traje dulje od 6 tjedana nepoznate etiologije) i 10 zdravih ispitanika. Svakog bolesnika je pregledao
dermatovenerolog-alergolog, kao i oralni patolog koji je iskljuÄio bolesti usne Å”upljine koje bi mogle utjecati na razinu
melatonina u bolesnika. Razina salivarnog melatonina odreÄena je testom ELISA, a svi ispitanici su ispunili standardizirani
dermatoloŔki upitnik o kvaliteti života (Dermatology Life Quality Index, DLQI) i PittsburŔki upitnik o kvaliteti sna (Pittsburgh
Sleep Quality Index, PSQI) istoga dana kad im je uzet uzorak sline za analizu. Prema rezultatima ovog istraživanja 86%
bolesnika s KSU-om imalo je snižene vrijednosti salivarnog melatonina koje znaÄajno koreliraju s loÅ”ijom kvalitetom života
u bolesnika s KSU-om. Ovo istraživanje je prvo istraživanje koje je analiziralo vrijednosti melatonina u bolesnika s KSU-om
i koje predlaže novu terapijsku moguÄnost u lijeÄenju KSU-e
Gingival Necrosis Caused by an Ill-Fitting Denture
U ovom prikazu opisali smo sluÄaj 80-godiÅ”njeg pacijenta koji je bio upuÄen u Zavod za oralnu medicinu StomatoloÅ”kog fakulteta u Zagrebu zbog gingivalnog ulkusa prisutnog osam dana. Na kliniÄkom
pregledu uoÄena je eksponirana kost na bezubom alveolarnom grebenu u podruÄju molara s desne strane mandibule veliÄine 0,8 cm u promjeru. InaÄe, pacijent je svakodnevno uzimao doksazosin jer je imao teÅ”koÄa s urinarnim traktom te ipatropij-bromid zbog respiratornih tegoba. Donju djelomiÄnu protezu nije promijenio veÄ Å”est godina. Na poÄetku je, toÄnije prva tri dana, bio lijeÄen parodontnim zavojem (Resopack, HagenWerken, NjemaÄka) uz preporuku da ne nosi protezu, no nakon tri dana kliniÄki pregled nije pokazao poboljÅ”anje stanja. Zato smo se odluÄili na lijeÄenje topikalnim kortikosteroidom (betametazon) i oralnim antiseptikom (klorheksidin-diglukonat) tri puta na dan. Nakon tri tjedna lezija je zacijelila. Naveden je popis moguÄih Äimbenika koji mogu rezultirati nastankom ulkusa gingive.We present a case of an 80-year-old male who was referred to the Department of Oral Medicine, School of Dental Medicine University of Zagreb, Croatia due to gingival ulcer which was present for eight days. Clinical examination has revealed exposed bone on the toothless alveolar ridge in the lower molar region on the right side of 0.8 cm in diameter. Otherwise, the patient was taking doxazosin due to urinary problems and ipatropium bromide due to respiratory problems. The patient wore a 6-year-old partial lower denture. He was initially treated with periodontal bandage (Resopack, HagenWerken, Germany) for the first three days and was instructed not to wear the denture; however, no benefit could be seen. Therefore, we added a local corticosteroid (betamethasone) and an oral antiseptic (chlorhexidine digluconate) applied three times a day. After 3 weeks the lesion healed. A list of possible causative factors regarding gingival ulcers is included
Sindrom pekuÄih usta ā goruÄa enigma
Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by an intraoral burning sensation and an absence of oral mucosal lesions and disturbances in laboratory findings. Burning symptoms usually affect the anterior two-thirds of the tongue, its lateral borders, hard palate and labial mucosa, but other oral cavity sites may also be affected. Taste alterations and a decrease in the salivary flow rate frequently accompany the burning symptoms. This condition mostly affects peri- and postmenopausal women. To date, the etiology of BMS remains unclear. This unknown etiology means that no appropriate treatment is currently available. A large number of the treatments and medications have been tried for BMS, but treatment management remains unsatisfactory in some patients. The purpose of this article is to present current knowledge on the treatment of BMS.Sindrom pekuÄih usta (SPU) kroniÄno je bolno stanje koje je karakterizirano osjeÄajem žarenja u usnoj Å”upljini bez vidljivih promjena na sluznici i poremeÄaja u laboratorijskim nalazima. Simptomi žarenja obiÄno zahvaÄaju prednje 2/3 treÄine i lateralne povrÅ”ine jezika, tvrdo nepce, labijalnu sluznicu, ali može biti zahvaÄena bilo koja regija u usnoj Å”upljini. Simptomi žarenja obiÄno su praÄeni promjenom osjeta okusa te smanjenim luÄenjem sline. Ovo stanje najviÅ”e pogaÄa žene u peri- i postmenopauzi. S obzirom na to da je etiologija SPU-a nepoznata, ne postoji niti odgovarajuÄe lijeÄenje. Dostupno je viÅ”e razliÄitih terapija i lijekova za SPU, meÄutim, lijeÄenje kod pojedinih pacijenata i dalje je bezuspjeÅ”no. Svrha ovog rada je prikazati trenutno znanje o lijeÄenju SPU-a
Suvremeni pristup lijeÄenju oralnog mukozitisa: pregledni rad
Oral mucositis (OM) is a serious inflammation of the mucosa and occurs in patients with head and neck cancer (HNC) who are being treated with radiotherapy (RT) and/or chemotherapy (CT), and in patients undergoing hematopoietic stem cell transplantation (HSCT). The inflammation accompanied with painful ulcerations inside the oral cavity impairs its function making the basic functions like eating and speech hard or even impossible. It usually occurs at the end of the first week of RT and lasts for several weeks after cessation. The intensity of OM can sometimes lead to discontinuation of RT. The degree of mucositis regarding chemotherapy depends on the type of antineoplastic drug, therapeutic procedure, duration of the therapy and dose, as well as previous exposure of the oral cavity to toxic agents.
Prolonged or repeated administration of lower doses of chemotherapy is associated with a higher chance of developing oral mucositis comparing to a bolus, while chronomodulation of chemotherapy reduces the possibility of mucositis without affecting antineoplastic activity. The treatment of OM is symptomatic, as there is still no effective treatment. In this review paper, several contemporary options for alleviating the symptoms of oral mucositis are listed.Oralni mukozitis (OM) ozbiljna je upala sluznice i javlja se u bolesnika s karcinomom glave i vrata (HNC) koji se lijeÄe radioterapijom (RT) i/ili kemoterapijom (CT) te u bolesnika koji su podvrgnuti transplantaciji hematopoetskih matiÄnih stanica (HSCT). Upala praÄena bolnim ulceracijama unutar usne Å”upljine naruÅ”ava njezinu funkciju, ÄineÄi osnovne funkcije poput prehrane i govora teÅ”kim ili Äak nemoguÄim. ObiÄno se javlja na kraju prvog tjedna radioterapije i traje nekoliko tjedana nakon prestanka. Intenzitet oralnog mukozitisa ponekad može dovesti do prekida radioterapije. Stupanj mukozitisa kod kemoterapije ovisi o vrsti antineoplastiÄnog lijeka, terapijskom postupku, trajanju terapije i dozi, kao i o prethodnoj izloženosti usne Å”upljine toksiÄnim agensima. Produljena ili ponovljena primjena nižih doza kemoterapije povezana je s veÄom Å”ansom za razvoj oralnog mukozitisa u usporedbi s bolusom, dok kronomodulacija kemoterapije smanjuje moguÄnost mukozitisa bez utjecaja na antineoplastiÄno djelovanje. LijeÄenje oralnog mukozitisa je simptomatsko jer joÅ” uvijek nema uÄinkovitog lijeka. U ovom preglednom radu navodi se nekoliko suvremenih opcija za ublažavanje simptoma oralnog mukozitisa
Lijekovima izazvane oralne ulceracije: prikaz sluÄaja
A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Differential diagnosis of oral ulcerations included drug induced oral ulcerations, paraneoplastic pemphigus, viral ulcerations (cytomegalovirus, herpes simplex viruses), fungal ulcerations (candidiasis, aspergillosis, histoplasmosis, cryptococcosis) and bacterial ulcerations, as well as neutropenic ulcers. One of the possible explanations was that the lesions were due to the use of drugs, the more so as oral lesions evolved when the doses of allopurinol and chlorambucil were increased, and subsided when the doses of both drugs were decreased. However, we could not establish
for sure whether the lesions were due to allopurinol or chlorambucil. According to literature data, allopurinol is one of the most frequent drugs known to induce skin adverse reactions, therefore we assumed that it was the culprit drug. Unfortunately, several weeks later the patient died from sepsis, pneumonia with respiratory insufficiency and multiorgan failure.Bolesnik u dobi od 70 godina upuÄen je na Zavod za oralnu medicinu zbog nekoliko oralnih ulceracija na lijevoj obraznoj sluznici veliÄine oko pola centimetra u promjeru te na gingivi. InaÄe je bolovao od kroniÄne limfocitne leukemije, hipogamaglobulinemije, kroniÄne bubrežne insufi cijencije s potpunom afunkcijom desnog bubrega, astme, hipertenzije, gastritisa i hiperplazije prostate. Diferencijalna dijagnoza oralnih ulceracija ukljuÄivala je oralne ulceracije uslijed uzimanja lijekova, paraneoplastiÄni pemfi gus, virusne ulceracije (citomegalovirus, herpes simpleks viruse), gljiviÄne ulceracije (kandidijaza, aspergiloza, histoplazmoza, kriptokokoza), bakterijske ulceracije te neutropeniÄne ulceracije. Jedno od moguÄih objaÅ”njenja
je bilo da su lezije vjerojatno nastale uslijed uzimanja lijekova, jer su se pojavile kada se doza alopurinola i klorambucila poveÄala, a poÄele su nestajati kada se doza tih lijekova smanjila. Ipak, nismo sigurni koji je od ova dva lijeka doveo do nastanka lezija, jer je nažalost nekoliko tjedana poslije bolesnik izdahnuo uslijed sepse, pneumonije i respiracijske insuficijencije te viÅ”eorganskog zatajenja
Simultana pojava oralnog i kožnog anaplastiÄnog limfoma velikih T stanica
We present case of oral and skin anaplastic T-cell lymphoma in a 68-year-old woman. The patient presented with extensive ulcerations and necrotic tissue on the left mandibular gingiva. Orthopantomogram finding showed extensive necrolytic lesions of the adjacent mandible. Biopsy finding of oral lesions and subsequently of the skin confirmed the diagnosis of anaplastic T-cell lymphoma. The bridge on the teeth 35-37 was taken out. After three cycles of chemotherapy, oral lesions subsided, unlike skin lesions. Dentists should be aware that differential diagnosis when dealing with oral ulcerations might be the result of certain malignant hematologic diseases.U radu se prikazuje sluÄaj oralnog i kožnog anaplastiÄnog limfoma velikih T stanica u 68-godiÅ”nje osobe. U bolesnice su na prvom pregledu uoÄene opsežne ulceracije i nekrotiÄno tkivo u podruÄju gingive na mandibuli lijeve strane lica. Na ortopantomogramu su se vidjele opsežne nekrolitiÄne lezije na kosti mandibule toga dijela. PatohistoloÅ”ki nalaz sluznice usne Å”upljine, a poslije i kože potvrdio je dijagnozu anaplastiÄnog limfoma velikih T stanica. Most na zubima 35-37 je izvaÄen. Nakon tri ciklusa kemoterapije oralne lezije su se povukle, za razliku od kožnih lezija. Stomatolozi pri diferencijalnoj dijagnostici oralnih ulceracija moraju imati na umu i moguÄu povezanost tih lezija s malignim hematoloÅ”kim bolestima
Simultana pojava oralnog i kožnog anaplastiÄnog limfoma velikih T stanica
We present case of oral and skin anaplastic T-cell lymphoma in a 68-year-old woman. The patient presented with extensive ulcerations and necrotic tissue on the left mandibular gingiva. Orthopantomogram finding showed extensive necrolytic lesions of the adjacent mandible. Biopsy finding of oral lesions and subsequently of the skin confirmed the diagnosis of anaplastic T-cell lymphoma. The bridge on the teeth 35-37 was taken out. After three cycles of chemotherapy, oral lesions subsided, unlike skin lesions. Dentists should be aware that differential diagnosis when dealing with oral ulcerations might be the result of certain malignant hematologic diseases.U radu se prikazuje sluÄaj oralnog i kožnog anaplastiÄnog limfoma velikih T stanica u 68-godiÅ”nje osobe. U bolesnice su na prvom pregledu uoÄene opsežne ulceracije i nekrotiÄno tkivo u podruÄju gingive na mandibuli lijeve strane lica. Na ortopantomogramu su se vidjele opsežne nekrolitiÄne lezije na kosti mandibule toga dijela. PatohistoloÅ”ki nalaz sluznice usne Å”upljine, a poslije i kože potvrdio je dijagnozu anaplastiÄnog limfoma velikih T stanica. Most na zubima 35-37 je izvaÄen. Nakon tri ciklusa kemoterapije oralne lezije su se povukle, za razliku od kožnih lezija. Stomatolozi pri diferencijalnoj dijagnostici oralnih ulceracija moraju imati na umu i moguÄu povezanost tih lezija s malignim hematoloÅ”kim bolestima