Black Hole Horizon Fluctuations

It is generally admitted that gravitational interactions become large at an invariant distance of order $1$ from the black hole horizon. We show that due to the ``atmosphere'' of high angular particles near the horizon strong gravitational interactions already occur at an invariant distance of the order of $\sqrt[3]{M}$. The implications of these results for the origin of black hole radiation, the meaning of black hole entropy and the information puzzle are discussed.Comment: Latex, 22 pages (minor corrections and precisions added

Ribosomal RNA Synthesis in Chronic Lymphocytic Leukaemia

Lymphocytes from patients with chronic lymphocytic leukaemia make large amounts of stable, rapidly labelled high molecular weight RNA, but ribosomal RNA methylation is normal. However, fewer ribosomes are available for protein synthesis than in normal lymphocytes

Fate of the Black String Instability

Gregory and Laflamme showed that certain nonextremal black strings (and p-branes) are unstable to linearized perturbations. It is widely believed that this instability will cause the black string horizon to classically pinch off and then quantum mechanically separate, resulting in higher dimensional black holes. We argue that this cannot happen. Under very mild assumptions, classical event horizons cannot pinch off. Instead, they settle down to new static black string solutions which are not translationally invariant along the string.Comment: 11 pages, v2: few clarifications and references adde

The usefulness of CA15.3, mucin-like carcinoma-associated antigen and carcinoembryonic antigen in determining the clinical course in patients with metastatic breast cancer

Levels of mucin-like carcinoma-associated antigen (MCA), CA15.3 and carcinoembryonic antigen (CEA) were measured in consecutive serum samples of 40 women with metastatic breast cancer. A change in antigen level of more than 25%, either an increase or a decrease, was considered to predict progressive or responsive disease respectively. A change of less than 25% was considered to predict stable disease. MCA, CA15.3 and CEA were elevated in the serum of 68%, 76% and 48% of the patients respectively (P<0.05). The overall prediction of clinical course was similar for all three markers. A more than 25% increase of MCA, CA15.3, and CEA was observed in 61%, 54% and 36% respectively. The predictive value of a more than 25% increase was high for all three markers: 94%, 94%, 83%. Changes in marker levels were correlated with each other. Logistic regression analysis showed that combining MCA and CA15.3 did not improve the prediction further. In conclusion, these tumour markers may help in evaluating the disease course and there is no advantage in combining MCA and CA15.3

Volume modulus inflection point inflation and the gravitino mass problem

Several models of inflection point inflation with the volume modulus as the inflaton are investigated. Non-perturbative superpotentials containing two gaugino condensation terms or one such term with threshold corrections are considered. It is shown that the gravitino mass may be much smaller than the Hubble scale during inflation if at least one of the non-perturbative terms has a positive exponent. Higher order corrections to the Kahler potential have to be taken into account in such models. Those corrections are used to stabilize the potential in the axion direction in the vicinity of the inflection point. Models with only negative exponents require uplifting and in consequence have the supersymmetry breaking scale higher than the inflation scale. Fine-tuning of parameters and initial conditions is analyzed in some detail for both types of models. It is found that fine-tuning of parameters in models with heavy gravitino is much stronger than in models with light gravitino. It is shown that recently proposed time dependent potentials can provide a solution to the problem of the initial conditions only in models with heavy gravitino. Such potentials can not be used to relax fine tuning of parameters in any model because this would lead to values of the spectral index well outside the experimental bounds.Comment: 27 pages, 9 figures, comments and references added, version to be publishe

AdS Duals of Matrix Strings

We review recent work on the holographic duals of type II and heterotic matrix string theories described by warped AdS_3 supergravities. In particular, we compute the spectra of Kaluza-Klein primaries for type I, II supergravities on warped AdS_3xS^7 and match them with the primary operators in the dual two-dimensional gauge theories. The presence of non-trivial warp factors and dilaton profiles requires a modification of the familiar dictionary between masses and ``scaling'' dimensions of fields and operators. We present these modifications for the general case of domain wall/QFT correspondences between supergravities on warped AdS_{d+1}xS^q geometries and super Yang-Mills theories with 16 supercharges.Comment: 7 pages, Proceedings of the RTN workshop ``The quantum structure of spacetime and the geometric nature of fundamental interactions'', Leuven, September 200

The polarization of F1 strings into D2 branes: "Aut Caesar aut nihil"

We give matrix and supergravity descriptions of type IIA F-strings polarizing into cylindrical D2 branes. When a RR four-form field strength F_4 is turned on in a supersymmetric fashion (with 4 supercharges), a complete analysis of the solutions reveals the existence of a moduli space of F1 -> D2 polarizations (Caesar) for some fractional strengths of the perturbation, and of no polarization whatsoever (nihil) for all other strengths of the perturbation. This is a very intriguing phenomenon, whose physical implications we can only speculate about. In the matrix description of the polarization we use the Non-Abelian Born-Infeld action in an extreme regime, where the commutators of the fields are much larger than 1. The validity of the results we obtain, provides a direct confirmation of this action, although is does not confirm or disprove the symmetrized trace prescription.Comment: 14 page

Fast Scramblers Of Small Size

We investigate various geometrical aspects of the notion of `optical depth' in the thermal atmosphere of black hole horizons. Optical depth has been proposed as a measure of fast-crambling times in such black hole systems, and the associated optical metric suggests that classical chaos plays a leading role in the actual scrambling mechanism. We study the behavior of the optical depth with the size of the system and find that AdS/CFT phase transitions with topology change occur naturally as the scrambler becomes smaller than its thermal length. In the context of detailed AdS/CFT models based on D-branes, T-duality implies that small scramblers are described in terms of matrix quantum mechanics.Comment: 14 pages, 3 figures. Added reference

Dementia, infections and vaccines: 30 years of controversy

This paper reports the proceedings of a virtual meeting convened by the European Interdisciplinary Council on Ageing (EICA), to discuss the involvement of infectious disorders in the pathogenesis of dementia and neurological disorders leading to dementia. We recap how our view of the infectious etiology of dementia has changed over the last 30&nbsp;years in light of emerging evidence, and&nbsp;we present evidence in support of the implication of infection in dementia, notably Alzheimer’s disease (AD). The bacteria and viruses thought to be responsible for neuroinflammation and neurological damage are reviewed. We then review the genetic basis for neuroinflammation and dementia, highlighting the genes that are currently the focus of investigation as potential targets for therapy. Next, we describe the antimicrobial hypothesis of dementia, notably the intriguing possibility that amyloid beta may itself possess antimicrobial properties. We further describe the clinical relevance of the gut–brain axis in dementia, the mechanisms by which infection can move from the intestine to the brain, and recent findings regarding dysbiosis patterns in patients with AD. We review the involvement of specific pathogens in neurological disorders, i.e. SARS-CoV-2, human immunodeficiency virus (HIV), herpes simplex virus type 1 (HSV1), and influenza. Finally, we look at the role of vaccination to prevent dementia. In conclusion, there is a large body of evidence supporting the involvement of various infectious pathogens in the pathogenesis of dementia, but large-scale studies with long-term follow-up are needed to elucidate the role that infection may play, especially before subclinical or clinical disease is present

Improved results for N=(2,2) super Yang-Mills theory using supersymmetric discrete light-cone quantization

We consider the (1+1)-dimensional ${\cal N}=(2,2)$ super Yang--Mills theory which is obtained by dimensionally reducing ${\cal N}=1$ super Yang--Mills theory in four dimension to two dimensions. We do our calculations in the large-$N_c$ approximation using Supersymmetric Discrete Light Cone Quantization. The objective is to calculate quantities that might be investigated by researchers using other numerical methods. We present a precision study of the low-mass spectrum and the stress-energy correlator $$. We find that the mass gap of this theory closes as the numerical resolution goes to infinity and that the correlator in the intermediate $r$ region behaves like $r^{-4.75}$.Comment: 18 pages, 8 figure