Evaluation of criteria of trypanotolerance

Evaluates teh criteria for trypanotolerance including three related characterstics, v.z. the ability to control parasitaemia, the ability to control anaemia, and the ability to develop an effective immune response

Fission-fusion dynamics over large distances in raven non-breeders

The influence of fission-fusion dynamics, i.e., temporal variation in group size and composition, on social complexity has been studied in large-brained mammals that rely on social bonds. Little is known about birds, even though some species like ravens have recently received attention for their socio-cognitive skills and use of social bonds. While raven breeders defend territories year-round, non-breeders roam through large areas and form groups at food sources or night roosts. We here examined the fission-fusion patterns of non-breeding ravens over years, investigating whether birds meet repeatedly either at the same or at different locations. We combined four large datasets: presence-absence observations from two study sites (Austria, Italy) and GPS-tracking of ravens across two study areas (Austria, France). As expected, we found a highly dynamic system in which individuals with long phases of temporary settlement had a high probability of meeting others. Although GPS-tagged ravens spread out over thousands of square kilometres, we found repeated associations between almost half of the possible combinations at different locations. Such a system makes repeated interactions between individuals at different sites possible and likely. High fission-fusion dynamics may thus not hinder but shape the social complexity of ravens and, possibly, other long-term bonded birds

International longitudinal registry of patients with atrial fibrillation and treated with rivaroxaban: RIVaroxaban Evaluation in Real life setting (RIVER)

Background Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in everyday practice. RIVER (RIVaroxaban Evaluation in Real life setting) is an ongoing international, prospective registry of patients with newly diagnosed non-valvular atrial fibrillation (NVAF) and at least one investigator-determined risk factor for stroke who received rivaroxaban as an initial treatment for the prevention of thromboembolic stroke. The aim of this paper is to describe the design of the RIVER registry and baseline characteristics of patients with newly diagnosed NVAF who received rivaroxaban as an initial treatment. Methods and results Between January 2014 and June 2017, RIVER investigators recruited 5072 patients at 309 centres in 17 countries. The aim was to enroll consecutive patients at sites where rivaroxaban was already routinely prescribed for stroke prevention. Each patient is being followed up prospectively for a minimum of 2-years. The registry will capture data on the rate and nature of all thromboembolic events (stroke / systemic embolism), bleeding complications, all-cause mortality and other major cardiovascular events as they occur. Data quality is assured through a combination of remote electronic monitoring and onsite monitoring (including source data verification in 10% of cases). Patients were mostly enrolled by cardiologists (n = 3776, 74.6%), by internal medicine specialists 14.2% (n = 718) and by primary care/general practice physicians 8.2% (n = 417). The mean (SD) age of the population was 69.5 (11.0) years, 44.3% were women. Mean (SD) CHADS2 score was 1.9 (1.2) and CHA2DS2-VASc scores was 3.2 (1.6). Almost all patients (98.5%) were prescribed with once daily dose of rivaroxaban, most commonly 20 mg (76.5%) and 15 mg (20.0%) as their initial treatment; 17.9% of patients received concomitant antiplatelet therapy. Most patients enrolled in RIVER met the recommended threshold for AC therapy (86.6% for 2012 ESC Guidelines, and 79.8% of patients according to 2016 ESC Guidelines). Conclusions The RIVER prospective registry will expand our knowledge of how rivaroxaban is prescribed in everyday practice and whether evidence from clinical trials can be translated to the broader cross-section of patients in the real world

Profitability, efficiency and comparative advantage of African cattle meat and milk production: the case of trypanotolerant village cattle production

Trypanosomiasis is a major constraint to increased food production in Africa as it limits livestock production and mixed farming over an area of 10 million km2 • The use of African trypanotolerant breeds of cattle is one approach to control trypanosomiasis that is being given increasing attention. This paper examines under what circumstances trypanotolerant village cattle enterprises can be economically viable in regions of origin and areas of introduction. On-going production is analysed in four countries using cost-benefit analyses. Comparative advantage and subsidies received are also estimated. Results indicate that resources for trypanotolerant cattle production are efficiently allocated as the sector has a comparative advantage and contributes effectively to the national welfare. Financial returns to producers are attractive and by comparing social and private prices important constraints are identified to improve profitability

Modelling possible effects of strategic nutritional interventions on national N'Dama cattle production in The Gambia

Presents the results of an observation and analysis trial carried out to determine the responses of N'Dama cattle to strategic nutritional interventions over a ten-year period using a simulation model of the national cattle herd production

Profitability, efficiency and comparative advantage of African cattle meat and milk production: The case of trypanotolerant village cattle production

Trypanosomiasis is a major constraint to increased food production in Africa as it limits livestock production and mixed farming over an area of 10 million km2. The use of African trypanotolerant breeds of cattle is one approach to control trypanosomiasis that is being given increasing attention.This paper examines under what circumstances trypanotolerant village cattle enterprises can be economically viable in regions of origin and areas of introduction. On-going production is analysed in four countries using cost-benefit analyses. Comparative advantage and subsidies received are also estimated. Results indicate that resources for trypanotolerant cattle production are efficiently allocated as the sector has a comparative advantage and contributes effectively to the national welfare. Financial returns to producers are attractive and by comparing social and private prices important constraints are identified to improve profitability