Thermodynamic and kinematic structure of tropical cyclones in the western North Pacific based on ACARS/AMDAR

Meteorological variables are often reported by commercial aircraft flying around tropical cyclones (TCs). They are archived in Aircraft Communications, Addressing, and Reporting System/Aircraft Meteorological Data Relay (ACARS/AMDAR). Therefore, they are potentially useful for constructing a composite mean structure of TCs based on in-situ measurements. The number of temperature and wind observations are 4.0 × 106 and 1.0 × 104 within the radius of 1,200 km and 100 km from the TC center during 2010–2020, respectively. The warm-core potential temperature anomaly with respect to the climatology is 6.4 K, 9.1 K, and 14.4 K maximized around 300 hPa for weak, moderate, and strong TCs, respectively. The composite of the potential temperature anomaly potentially extends more than 1,000 km from the TC center in the upper troposphere, cautioning the typical definition of the environment. The region of significant upper-level positive potential temperature anomalies extends broadly with increasing TC intensity. Moreover, large TCs tend to have a broad and deep upper-level warm core for a given intensity. In addition, we ensured that a single observation of potential temperature around 300 hPa could be used as a proxy for minimum sea level pressure. Low-level inflow and upper-level outflow were detected in the ACARS/AMDAR data

Structural Dependent Ferromagnetic-Nonmagnetic Phase Change in FePtRu Films

Herein, we studied correlations between crystal structures and magnetic properties of FePt1−xRux films. At room temperature, the chemical disordered A1 films with 0≤x<0.20 and 0.20≤x≤1.00 exhibited ferromagnetic properties and paramagnetic properties, respectively. Curie temperature of the disordered film with x=0.30 was 200 K. In contrast, the ordered L10 films had ferromagnetic properties in a wider range of 0≤x<0.80 with the magnetic easy-axis perpendicular to the film plane. For 0≤x≤0.50, with the ordered structure, the films had high magnetization and high uniaxial magnetic anisotropy of over 107 erg cm−3. For x = 0.60–0.70 with the ordered structure, a temperature-dependent magnetic phase transition appeared, and magnetization reached its maximum value at around 200 K. Using this material system, we proposed a nanopatterning method involving a ferromagnetic-paramagnetic phase change due to the ordered-disordered structural transformation

A Case of Metastatic Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome-Associated Renal Cell Carcinoma Treated with a Sequence of Axitinib and Nivolumab Following Cytoreductive Nephrectomy

Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) associated renal cell carcinoma (RCC) is an aggressive form of type 2 papillary RCC caused by deficiency of the fumarate hydratase gene. For patients with metastatic disease, no standard treatment has been established with dismal prognosis. We report a case of metastatic HLRCC-associated RCC in a 65-year-old Japanese male whose clinical features mimicked advanced renal pelvic cancer. A durable response was achieved with a sequence of axitinib and nivolumab after cytoreductive and diagnostic nephrectomy. Their potential therapeutic roles in the management of metastatic HLRCC-associated RCC have been discussed based on its molecular and biological backgrounds

オルメサルタンは、JNK及びp38シグナル経路を抑制することで、周期的機械的伸展による培養大動脈平滑筋細胞死を抑制する

Acute aortic dissection (AAD) is a life-threating disease; however, there is almost no effective pharmacotherapy for it. An increase in c-Jun N-terminal kinase (JNK) phosphorylation and smooth muscle cell (SMC) apoptosis is observed tissues in patients with AAD. Therefore, we hypothesized that an acute rise in blood pressure leads to SMC death through phosphorylation of JNK or p38, which may cause AAD. We investigated the influence of cyclic mechanical stretch, which mimics an acute increase in blood pressure, on cultured rat aortic SMCs (RASMCs) and examined the changes in JNK and p38 phosphorylation. Further, we investigated the effect of olmesartan, an angiotensin II receptor blocker, on stretch-induced RASMC death. We found that mechanical stretch-induced RASMC death in a time-dependent manner, which correlated with the phosphorylation of JNK and p38. Olmesartan inhibited RASMC death and the phosphorylation of JNK and p38. JNK and p38 inhibitors reversed stretch-induced RASMC death. These results suggest that acute mechanical stretch causes JNK and p38 phosphorylation, which may result in SMC death leading to aortic dissection. Olmesartan may be used for pharmacotherapy to prevent aortic dissection, independent of its blood pressure-lowering effect, through its inhibition of JNK and p38 phosphorylation.博士（医学）・甲第627号・平成27年3月16日Copyright © 2014 Japanese Pharmacological Society. Production and hosting by Elsevier B.V

A RESOURCE ANALYSIS ON SOLAR PHOTOVOLTAIC GENERATION BY A REMOTE SENSING APPROACH

ABSTRACT A planning of large-scale PV system installed in a desert has been studied. This study has defined the conditions of estimation for suitable land in order to set up large-scale photovoltaic with remote sensing. Basis requirements for the land selection of PV systems are considered that the land surface should be flat and rigid and should not move like sand dune, mountain and river basin are also excluded. Authors show the identified examples of a flat ground, a sand dune and mountain by the combination of types of processed images, i.e. the image which is presumed as conglomerate desert, the image which is presumed as desert steppe, and the image which is extracted as an edge line by using various filters. So far, we could indicate that a detail classification algorithm for right land is developed. It is concluded that this proposed method can provide sufficient information for the planning of PV system installations

Synthesis and Evaluation of 1,3a,6a-triazapentalene (TAP)-bonded system

A method of synthesizing a directly connected 1,3a,6a-triazapentalene (TAP) ring system as a linearly bonded aromatic system with a planar form was established. Various TAP-dimers and a 2-alkyl-TAP-trimer were synthesized and their fluorescence properties were evaluated. Although the direct connection of the TAP ring with other TAP rings did not affect the fluorescence properties in diluted solvent, TAP-dimers showed unique fluorescence properties derived from the aggregation state under highly concentrated conditions. In particular, TAP-dimer 5f showed aggregation-induced emission in highly concentrated solution, and 5b showed typical mechanochromic fluorescence in the solid state despite their compact molecular size