GPTArticleExtractor: An Automated Workflow for Magnetic Material Database Construction

A comprehensive database of magnetic materials is valuable for researching the properties of magnetic materials and discovering new ones. This article introduces a novel workflow that leverages large language models for extracting key information from scientific literature. From 22,120 articles in the Journal of Magnetism and Magnetic Materials, a database containing 2,035 magnetic materials was automatically generated, with ferromagnetic materials constituting 76% of the total. Each entry in the database includes the material's chemical compounds, as well as related structures (space group, crystal structure) and magnetic temperatures (Curie, N'eel, and other transitional temperatures). To ensure data accuracy, we meticulously compared each entry in the database against the original literature, verifying the precision and reliability of each entry

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or “golden rules,” for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice

Lipid Induced Overexpression of NF-κB in Skeletal Muscle Cells is Linked to Insulin Resistance

Lipid induced NF-κB activation is known to be associated with insulin resistance and type2 diabetes. Here we show that incubation of L6 skeletal muscle cells with palmitate significantly increased NF-κB p65 and NF-κB p50 expression along with their phosphorylation. NF-κB p65 siRNA inhibited palmitate induced overexpression of NF-κB p65 indicating palmitate effect on transcriptional activation. RT-PCR and real time PCR experiments also showed a significant increase in NF-κB p65 gene expression due to palmitate. Overexpression of NF-κB p65 by palmitate was linked to impairment of insulin activity. Palmitate effect on NF-κB gene and protein expression was found to be mediated by phospho-PKCɛ as calphostin C (an inhibitor of PKC) and ɛV1 (PKCɛ translocation inhibitor) significantly reduced NF-κB expression. To understand the underlying mechanism, we purified NF-κB and pPKCɛ from palmitate incubated skeletal muscle cells and their interaction in cell free system demonstrated the transfer of phosphate from PKCɛ to NF-κB. This prompted us to transduct pPKCɛ to the skeletal muscle cells. These cells showed increased amount of pNF-κB and NF-κB. Excess of NF-κB p65 pool thus created in the cells made them insulin resistant. Addition of NF-κB p65 siRNA and SN50 inhibited palmitate induced NF-κB p65 expression indicating NF-κB regulation of its gene expression. Increase of NF-κB did not affect the activation of IKK/IκB indicating NF-κB p65 expression to be a distinct effect of palmitate. Since NF-κB p65 is linked to several diseases, including type2 diabetes, this report may be important in understanding the pathogenicity of these diseases

Insulin Resistance due to Lipid-Induced Signaling Defects could be Prevented by Mahanine

It is well known that free fatty acids (FFAs) play a key role in implementing insulin resistance and type 2 diabetes. Resources of chemical compounds that intervene the derogatory effect of FFAs are indeed very limited. We have isolated mahanine, a carbazole alkaloid, from the leaves of Murraya koenegii that prevented palmitate-induced inhibition of insulin-stimulated phosphorylation of IRb, PI3K, PDK1, and Akt in L6 myotubes. This was also reflected in the palmitate-induced inhibition of insulinstimulated [3H] 2-DOG uptake by L6 myotubes, where palmitate adverse effect was significantly blocked by mahanine. Previous reports indicated that one of the major targets of lipid-induced damage in insulin signaling pathway resulting impairment of insulin sensitivity is insulin receptor (IR). Here, we have observed that palmitate significantly increased pPKCe in both cytosol and nuclear region of L6 myotubes in comparison to control. Translocation of pPKCe to the nucleus was associated with the impairment of HMGA1, the architectural transcription factor of IR gene and all these were reversed by mahanine. Palmitate-induced activation of IKK/IjB/NF-jB pathway was also attenuated by mahanine. Taken together, mahanine showed encouraging possibility to deal with lipid induced insulin resistance. In order to examine it further, mahanine was administered on nutritionally induced type 2 diabetic golden hamsters; it significantly improved hyperglycemia in all the treated animals. Our results, therefore, suggest that mahanine acts on two important sites of lipid induced insulin resistance (i) impairment of IR gene expression and (ii) activation of NF-jB pathway, thus, showing promise for its therapeutic choice for type 2 diabetes

Ten golden rules for optimal antibiotic use in hospital settings : the WARNING call to action

Abstract: Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or "golden rules," for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice

Ten golden rules for optimal antibiotic use in hospital settings : the WARNING call to action

Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or "golden rules," for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice