Polygenic in vivo validation of cancer mutations using transposons

The in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows multiple cancer mutations to be validated in each animal line. Animal lines are generated with multiple candidate cancer mutations using transposons. The candidate cancer genes are tagged and randomly expressed in somatic cells, allowing easy identification of the cancer genes involved in the generated tumours. This system presents a useful, generalised and efficient means for animal validation of cancer genes.Link_to_subscribed_fulltex

A search for pair-produced resonances in four-jet final states at root s=13 TeV with the ATLAS detector

A search for massive coloured resonances which are pair-produced and decay into two jets is presented. The analysis uses 36.7 fb−1 − 1 of √ s = 13 TeV pp collision data recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the background prediction is observed. Results are interpreted in a SUSY simplified model where the lightest supersymmetric particle is the top squark, ̃ t ~ , which decays promptly into two quarks through R-parity-violating couplings. Top squarks with masses in the range 100 GeV<̃<410 100 GeV < m t ~ < 410 GeV GeV are excluded at 95% confidence level. If the decay is into a b-quark and a light quark, a dedicated selection requiring two b-tags is used to exclude masses in the ranges 100 GeV<̃<470 100 GeV < m t ~ < 470 GeV GeV and 480 GeV<̃<610 480 GeV < m t ~ < 610 GeV GeV . Additional limits are set on the pair-production of massive colour-octet resonances

Measurements of electroweak Wjj production and constraints on anomalous gauge couplings with the ATLAS detector

Measurements of the electroweak production of a W boson in association with two jets at high dijet invariant mass are performed using root s = 7 and 8 TeV proton-proton collision data produced by the Large Hadron Collider, corresponding respectively to 4.7 and 20.2 fb(-1) of integrated luminosity collected by the ATLAS detector. The measurements are sensitive to the production of a W boson via a triple-gauge-boson vertex and include both the fiducial and differential cross sections of the electroweak process

UMA DESIGNER NA SERRA DO ABREU: A IDENTIDADE QUILOMBOLA NA PRODU??O ARTESANAL

A identidade cultural ? um conjunto de caracter?sticas que identifica um povo ou comunidade e que representa suas rela??es sociais e seus patrim?nios simb?licos. Dentre as caracter?sticas culturais normalmente associadas aos quilombos, temos a fixa??o das fam?lias em aglomerados de moradias nos quais existem apenas um local de entrada, a confec??o de artefatos cer?micos e outras formas de artesanato, e o hist?rico de sofrimento com a submiss?o e escraviza??o. O objetivo deste projeto ? promover o debate sobre o resgate e a historia da comunidade quilombola Serra do Abreu incentivando a cria??o de uma identidade visual pelas mulheres da comunidade, ensinando conhecimentos b?sicos de projeto de produto e avaliando como interferem nos produtos por elas produzidos. Por meio da etnografia acompanhamos semanalmente as atividades realizadas pelas mulheres, promovendo oficinas sobre a fabrica??o de artefatos cer?micos e de estamparia em tecidos, realizando reuni?es nas quais criamos a identidade visual das mulheres da comunidade. Em novas oficinas foram desenvolvidos onze looks inspirados em pain?is tem?ticos criados a partir de elementos do entorno e sete estampas para tecidos utilizando carimbos de folhas e flores da regi?o. Foram estampadas tamb?m pe?as cer?micas. Percebeu-se um movimento comunit?rio de maior envolvimento dessas mulheres com o esse trabalho, justificado pelas a??es de ensino de suas pr?ticas e saberes e a busca pela melhoria de suas t?cnicas atrav?s do intercambio de saberes com outras comunidades quilombolas e com entidades de ensino

Prevalence and associations of symptoms of upper extremities, repetitive strain injuries (RSI) and 'RSI-like condition'. A cross sectional study of bank workers in Northeast Brazil.

BACKGROUND: The repetitive strain injury syndrome (RSI) is a worldwide occupational health problem affecting all types of economic activities. We investigated the prevalence and some risk factors for RSI and related conditions, namely 'symptoms of upper limbs' and 'RSI-like condition'. METHODS: We conducted a cross-sectional study with 395 bank workers in Recife, Northeast Brazil. Symptoms of upper limbs and 'RSI-like condition' were assessed by a simple questionnaire, which was used to screen probable cases of RSI. The diagnosis of RSI was confirmed by clinical examination. The associations of potential risk factors and the outcomes were assessed by multiple logistic regression analysis. RESULTS: We found prevalence rates of 56% for symptoms of the upper limbs and 30% for 'RSI-like condition'. The estimated prevalence of clinically confirmed cases of RSI was 22%. Female sex and occupation (as cashier or clerk) increased the risk of all conditions, but the associations were stronger for cases of RSI than for less specific diagnoses of 'RSI-like condition' and symptoms of upper limbs. Age was inversely related to the risk of symptoms of upper limbs but not to 'RSI-like' or RSI. CONCLUSION: The variation in the magnitude of risk according to the outcome assessed suggests that previous studies using different definitions may not be immediately comparable. We propose the use of a simple instrument to screen cases of RSI in population based studies, which still needs to be validated in other populations. The high prevalence of RSI and related conditions in this population suggests the need for urgent interventions to tackle the problem, which could be directed to individuals at higher risk and to changes in the work organization and environment of the general population

Performance of the ATLAS Track Reconstruction Algorithms in Dense Environments in LHC Run 2

International audienceWith the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13  $\text {TeV}$ for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb$^{-1}$ of data collected by the ATLAS experiment and simulation of proton–proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13  $\text {TeV}$ . The impact of charged-particle separations and multiplicities on the track reconstruction performance is discussed. The track reconstruction efficiency in the cores of jets with transverse momenta between 200 and 1600 $\text {GeV}$ is quantified using a novel, data-driven, method. The method uses the energy loss, ${\text { d}}{} \textit{E}/d\textit{x}$ , to identify pixel clusters originating from two charged particles. Of the charged particles creating these clusters, the measured fraction that fail to be reconstructed is $0.061 \pm 0.006\ {\text {(stat.)}} \pm 0.014\ {\text {(syst.)}}$ and $0.093 \pm 0.017\ {\text {(stat.)}}\pm 0.021\ {\text {(syst.)}}$ for jet transverse momenta of 200–400  $\text {GeV}$ and 1400–1600  $\text {GeV}$ , respectively