Radical-Scavenging activities of total extracts and identification of four anthocyanin isomers from two purple-fleshed varieties of Ipomoea batatas L. produced in Burkina Faso, by hplc-ms/ms

peer reviewedAnthocyanins are bioactive compounds which, due to their free radical scavenging properties, can protect the human body against oxidative stress that can cause many diseases, such as cancer, aging. The Tuskegee purple Cap Vert and Tuskegee purple sweet potato (Ipomoea batatas L.) varieties are rich in anthocyanins. Indeed, their total anthocyanin contents are estimated at 0.211 and 0.122 mg/g of fresh plant material, respectively. And the antiradical activities of the varieties Tuskegee purple and Tuskegee purple Cap Vert extracts were estimated at 0.06 and 0.05 mg/mL respectively. The identification of anthocyanins in the extracts of the two sweet potato varieties was performed by HPLC-MS-UV, and HPLC-MS/MS analyses. Four anthocyanin isomers were identified in Tuskegee purple Cap Vert variety. These are : cyanidin 3-sophoroside-5-glucoside ; peonidin 3-sophoroside-5-glucoside ; cyanidin 3-laminaribioside-5-glucoside ; peonidin 3- laminaribioside-5-glucoside.3. Good health and well-being12. Responsible consumption and productio

Contribution à l'amélioration de modèles pour estimer les paramètres de stabilité de substances médicamenteuses :cas particuliers de l'acide acétylsalicylique

Doctorat en sciences pharmaceutiquesinfo:eu-repo/semantics/nonPublishe

A new method for pH-profile data treatment: Non linear parameter estimation

info:eu-repo/semantics/nonPublishe

An original algorithm for non linear parameter estimation of drug stability data

info:eu-repo/semantics/nonPublishe

Incorporating batch effects in the estimation of drug stability parameters using an Arrhenius model

The nonlinear estimation of drug stability parameters (energy of activation E(a) and shelf-life t(Y)) by conventional approaches employs equations relating drug content determination C at time t and temperature T. The identification procedures lead to the determination of only one initial drug content C0 for several different experiments. However, it is well known that because of experimental concentration variation or of intentional modification of the experimental schedule, there are as many initial drug contents as experiments. For these reasons, a method which takes into account batch effects is proposed to determine stability parameters and also all initial drug contents C(0j) where j is the index of experiment in one step. This method is more accurate from a statistical viewpoint and is suitable for data treatment in pharmaceutical industries where the initial drug content of each batch entering the stability program can be checked a posteriori. The application of this method is shown on real kinetic data from the hydrolysis of acetylsalicylic acid (ASA). Copyright (C) 1999 Elsevier Science B.V.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Stability parameter estimation at ambient temperature from studies at elevated temperatures

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Chromatographic determination of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cellular DNA: A validation study

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Improved kinetic parameter estimation in pH-profile data treatment

Statistical problems in temperature stability parameter estimation have been the subject of many papers whereas statistics in, pH-profile parameter estimation have focused little attention. However, the conventional two step method used in data treatment in both cases leads to identical statistical problems. The aim of this study is then to introduce a method that improves statistics in pH-profile parameter estimation. A one step non-linear method that takes into account the errors in drug content determination is proposed. A mathematical relationship between drug content C, pH and time t is tested. The proposed method allows the estimation of the specific kinetic constants and the dissociation constant (pK(a)) in a single run. The most likely experimental initial drug contents C(0j), where j is the index of a given experiment, are also determined. This approach that takes into account all relevant experimental information for the estimation of kinetic parameters is more rigorous from a statistical viewpoint than the classical two step methods. Kinetic data from acetylsalicylic acid (ASA) hydrolysis was used for the tests. (C) 2000 Elsevier Science B.V.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Determination of groundwater mercury (II) content using a disposable gold modified screen printed carbon electrode

Mercury (II) measurements were performed thanks to a newly developed electrochemical method using a disposable gold modified screen printed carbon electrode. The method has a wide dynamic range (1-100 μg/L), a good accuracy and a limit of detection in compliance with WHO standards. The application of the method to several groundwater samples made it possible to identify, for the first time, mercury content higher than the recommended WHO standard value in a gold mining activity area in the northern part of Burkina Faso. The accuracy of the assay was checked by ICP/MS.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Home-based practicies of complementary foods improvement are associated with better height-for-age z score in rural Burkina Faso

info:eu-repo/semantics/publishe