Metallicities of 0.3<z<1.0 Galaxies in the GOODS-North Field

We measure nebular oxygen abundances for 204 emission-line galaxies with redshifts 0.3<z<1.0 in the Great Observatories Origins Deep Survey North (GOODS-N) field using spectra from the Team Keck Redshift Survey (TKRS). We also provide an updated analytic prescription for estimating oxygen abundances using the traditional strong emission line ratio, R_{23}, based on the photoionization models of Kewley & Dopita (2003). We include an analytic formula for very crude metallicity estimates using the [NII]6584/Halpha ratio. Oxygen abundances for GOODS-N galaxies range from 8.2< 12+log(O/H)< 9.1 corresponding to metallicities between 0.3 and 2.5 times the solar value. This sample of galaxies exhibits a correlation between rest-frame blue luminosity and gas-phase metallicity (i.e., an L-Z relation), consistent with L-Z correlations of previously-studied intermediate-redshift samples. The zero point of the L-Z relation evolves with redshift in the sense that galaxies of a given luminosity become more metal poor at higher redshift. Galaxies in luminosity bins -18.5<M_B<-21.5 exhibit a decrease in average oxygen abundance by 0.14\pm0.05 dex from z=0 to z=1. This rate of metal enrichment means that 28\pm0.07% of metals in local galaxies have been synthesized since z=1, in reasonable agreement with the predictions based on published star formation rate densities which show that ~38% of stars in the universe have formed during the same interval. (Abridged)Comment: AASTeX, 49 pages, 16 figures, accepted for publication in The Astrophysical Journa

The Reddest DR3 SDSS/XMM Quasars

We have cross-correlated the SDSS DR3 Schneider et al. (2005) quasar catalog with the XMM-Newton archive. Color and redshift selections (g - r > 0.5 and 0.9 z < 2.1) result in a sample of 17 red, moderate redshift quasars. The redshift selection minimizes possible contamination due to host galaxy emission and Lyalpha forest absorption. Both optical and X-ray information are required to distinguish between the two likely remaining causes of the red colors: 1) dust-reddening and 2) an intrinsically red continuum. We find that 7 of 17 quasars can be classified as probable `intrinsically red' objects. These 7 quasars have unusually broad MgII emission lines (=10,500 km s^{-1}), moderately flat, but unabsorbed X-ray spectra =1.66+/-0.08), and low accretion rates (mdot/mdot_{Edd}} ~ 0.01). We suggest low accretion rates as a possible physical explanation for quasars with intrinsically red optical continua. We find that 8 of 17 quasars can be classified as dust-reddened. Three of these have upper-limits on the absorption column from X-ray spectral fits of N_H = 3-13 x 10^{22} cm^2, while the other five quasars must be absorbed by at least N_H = 10^{23} cm^2 in order to be consistent with a comparably selected alpha_{ox}-l_{uv} distribution. Two objects in the sample are unclassified.Comment: 20 pages, 12 figures, Accepted for publication in Ap

A New Probe of the Molecular Gas in Galaxies: Application to M101

Recent studies of nearby spiral galaxies suggest that photodissociation regions (PDRs) are capable of producing much of the observed HI in galaxy disks. In that case, measurements of the HI column density and the far-ultraviolet (FUV) photon flux provide a new probe of the volume density of the local underlying H_2. We develop the method and apply it to the giant Scd spiral M101 (NGC 5457). We find that, after correction for the best-estimate gradient of metallicity in the ISM of M101 and for the extinction of the ultraviolet emission, molecular gas with a narrow range of density from 30-1000 cm^-3 is found near star- forming regions at all radii in the disk of M101 out to a distance of 12' (approximately 26 kpc), close to the photometric limit of R_25 = 13.5'. In this picture, the ISM is virtually all molecular in the inner parts of M101. The strong decrease of the HI column density in the inner disk of the galaxy at R_G < 10 kpc is a consequence of a strong increase in the dust-to-gas ratio there, resulting in an increase of the H_2 formation rate on grains and a corresponding disappearance of hydrogen in its atomic form.Comment: accepted for publication in The Astrophysical Journal (1 August 2000); 29 pages including 20 figures (7 gif); AAS LaTex; contact authors for full resolution versions of gif figure

Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.

Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA samples from 51 MDS patients by single nucleotide polymorphism (SNP) arrays, and identified somatically acquired clonal genomic abnormalities in 21 patients (41%). Among the 33 patients with normal bone marrow cell karyotypes, 5 (15%) had clonal, somatically acquired aberrations by SNP array analysis, including 4 with segmental uniparental disomies (UPD) and 1 with three separate microdeletions. Each abnormality was detected more readily in CD34+ cells than in unselected bone marrow cells. Paired analysis of bone marrow and buccal cell DNA from each patient was necessary to distinguish true clonal genomic abnormalities from inherited copy number variations and regions with apparent loss of heterozygosity. UPDs affecting chromosome 7q were identified in two patients who had a rapidly deteriorating clinical course despite a low-risk International Prognostic Scoring System score. Further studies of larger numbers of patients will be needed to determine whether 7q UPD detected by SNP array analysis will identify higher risk MDS patients at diagnosis, analogous to those with 7q cytogenetic abnormalities

Confocal Blue Reflectance Imaging in Type 2 Idiopathic Macular Telangiectasia

PURPOSE. To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT). METHODS. In a prospective observational cross-sectional study, both eyes of 33 patients with type 2 IMT were examined by means of fundus biomicroscopy, fundus photography, fluorescein angiography, and optical coherence tomography (OCT). Confocal blue reflectance (CBR) imaging was performed using a confocal scanning laser ophthalmoscope (HRA2; Heidelberg Engineering, Heidelberg, Germany). To compare the results derived from different imaging modalities, an analysis was performed using image analysis software (Heidelberg Eye Explorer; Heidelberg Engineering). RESULTS. CBR imaging revealed a parafoveal area of increased reflectance that was slightly larger than the area of hyperfluorescence in late-phase fluorescein angiography. The area usually encompassed an oval parafoveal area, but sectors could be spared. A parafoveal area of increased CBR was detected in 98% of eyes that showed angiographic evidence for type 2 IMT. CONCLUSIONS. CBR imaging is a new, noninvasive, and sensitive method that may contribute to differentiate type 2 IMT from other diseases. Abnormalities of macular pigment distribution and Miiller cell pathology may contribute to the phenomenon of increased CBR and thus the pathophysiology of type 2 IMT

Modelling microlayer formation in boiling sodium

During boiling at a solid surface, it is often the case that a liquid layer of a few microns of thickness (’microlayer’) is formed beneath a bubble growing on the heated surface. Microlayers have been observed forming beneath bubbles in various transparent fluids, such as water and refrigerants, subsequently depleting due to evaporation, thus contributing significantly to bubble growth and possibly generating the majority of vapor in a bubble. On the other hand, boiling of opaque fluids, such as liquid metals, is not amenable to optical observations, and microlayers have not yet been observed in liquid metals. Among that class of fluids is sodium, suitable as a coolant for nuclear reactors and as the working fluid in phase-change solar power receivers. In order to support these applications, it is necessary to understand the boiling behavior of sodium and identify the parameters that might influence microlayer formation during boiling of this important fluid. This paper presents simulations of the hydrodynamics of sodium vapor bubble growth at a surface. An interface capturing flow solver has been implemented in the OpenFOAM code and used to predict the behavior of a sodium vapor bubble near a solid surface in typical boiling conditions. The methodology has been validated using recently reported direct experimental observations of microlayer formation in water and then applied to sodium boiling cases. Simulations indicate that microlayers are formed in sodium in a similar fashion to water. Comparison of simulation results with an extant algebraic model of microlayer formation showed good agreement, which increases confidence in the current predictions of microlayer formation. Typical values of microlayer thickness thus computed indicate that the microlayer is likely to play an important role during bubble growth in sodium

Hyperbolic planforms in relation to visual edges and textures perception

We propose to use bifurcation theory and pattern formation as theoretical probes for various hypotheses about the neural organization of the brain. This allows us to make predictions about the kinds of patterns that should be observed in the activity of real brains through, e.g. optical imaging, and opens the door to the design of experiments to test these hypotheses. We study the specific problem of visual edges and textures perception and suggest that these features may be represented at the population level in the visual cortex as a specific second-order tensor, the structure tensor, perhaps within a hypercolumn. We then extend the classical ring model to this case and show that its natural framework is the non-Euclidean hyperbolic geometry. This brings in the beautiful structure of its group of isometries and certain of its subgroups which have a direct interpretation in terms of the organization of the neural populations that are assumed to encode the structure tensor. By studying the bifurcations of the solutions of the structure tensor equations, the analog of the classical Wilson and Cowan equations, under the assumption of invariance with respect to the action of these subgroups, we predict the appearance of characteristic patterns. These patterns can be described by what we call hyperbolic or H-planforms that are reminiscent of Euclidean planar waves and of the planforms that were used in [1, 2] to account for some visual hallucinations. If these patterns could be observed through brain imaging techniques they would reveal the built-in or acquired invariance of the neural organization to the action of the corresponding subgroups.Comment: 34 pages, 11 figures, 2 table

Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

BACKGROUND: Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing. Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy by deregulation of cell growth and division. Our previous pilot study with pairs of malignant and normal breast tissues identified correlated methylation of two pairs of genes - HIN-1/RASSFIA and RIL/CDH13 - with expression of estrogen receptors (ER), progesterone receptors (PR), and HER2 (HER2). To determine the impact of methylation on clinical outcome, we have conducted a larger study with breast cancers for which time to first recurrence and overall survival are known. METHODS: Tumors from 193 patients with early stage breast cancer who received no adjuvant systemic therapy were used to analyze methylation levels of RIL, HIN-1, RASSF1A and CDH13 genes for associations with known predictive and prognostic factors and for impact on time to first recurrence and overall survival. RESULTS: In this study, we found that ER was associated with RASSF1A methylation (p < 0.001) and HIN-1 methylation (p = 0.002). PR was associated with RIL methylation (p = 0.012), HIN-1 (p = 0.002), and RASSF1A methylation (p = 0.019). Tumor size was associated with RIL and CDH13 methylation (both p = 0.002), and S-phase was associated with RIL methylation (p = 0.036). Only RASSF1A was associated with worse time to first recurrence (p = 0.045) and worse overall survival (p = 0.016) after adjusting for age, tumor size, S-phase, estrogen receptor and progesterone receptor. CONCLUSIONS: Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival. Our data suggest that RASSF1A methylation could be a potential prognostic biomarker

The complete submillimetre spectrum of NGC 891

Submillimetre maps of NGC 891 have been obtained with the PRONAOS balloon-borne telescope and with the ISOPHOT instrument on board the ISO satellite. In this article, we also gather data from IRAS and SCUBA to present the complete submillimetre spectrum of this nearby edge-on spiral galaxy. We derive submillimetre emission profiles along the major axis. The modified blackbody fits, assuming a single dust component, lead to temperatures of 19-24 K toward the centre and 18-20 K toward the edges, with possible variations of the dust spectral index from 1.4 to 2. The two-component fits lead to a warm component temperature of 29 K all along the galaxy with a cold component at 16 K. The interstellar medium masses derived by these two methods are quite different: 4.6 x 10^9 Mo in the case of the one-component model and 12 x 10^9 Mo in the case of the two-component one. This two-component fit indicates that the cold dust to warm dust ratio is 20 to 40, the highest values being in the wings of this galaxy. Comparing to dust mass estimates, both estimations of the ISM mass are consistent with a gas to dust mass ratio of 240, which is close to the Milky Way value. Our results illustrate the importance of accurate submillimetre spectra to derive masses of the interstellar medium in galaxies.Comment: 5 pages, 2 figures, accepted May 2003 in the MNRA