904 research outputs found
On computational irreducibility and the predictability of complex physical systems
Using elementary cellular automata (CA) as an example, we show how to
coarse-grain CA in all classes of Wolfram's classification. We find that
computationally irreducible (CIR) physical processes can be predictable and
even computationally reducible at a coarse-grained level of description. The
resulting coarse-grained CA which we construct emulate the large-scale behavior
of the original systems without accounting for small-scale details. At least
one of the CA that can be coarse-grained is irreducible and known to be a
universal Turing machine.Comment: 4 pages, 2 figures, to be published in PR
Repairing the Damage: The Effect of Price Expectations on Auto-Repair Price Quotes
In this paper we investigate whether sellers treat consumers differently on the basis of how well-informed consumers appear to be. We implement a large-scale field experiment in which callers request price quotes from automotive repair shops. We show that sellers alter their initial price quotes depending on whether consumers appear to be well-informed, uninformed, or poorly informed about market prices. We find that repair shops quote higher prices to callers who cite a higher expected price. We find that women are quoted higher prices than men when callers signal that they are uninformed about market prices. However, gender differences disappear when callers mention an expected price for the repair. Finally, we find that repair shops are more likely to offer a price concession if asked to do so by a woman than a man
Non-invertible transformations and spatiotemporal randomness
We generalize the exact solution to the Bernoulli shift map. Under certain
conditions, the generalized functions can produce unpredictable dynamics. We
use the properties of the generalized functions to show that certain dynamical
systems can generate random dynamics. For instance, the chaotic Chua's circuit
coupled to a circuit with a non-invertible I-V characteristic can generate
unpredictable dynamics. In general, a nonperiodic time-series with truncated
exponential behavior can be converted into unpredictable dynamics using
non-invertible transformations. Using a new theoretical framework for chaos and
randomness, we investigate some classes of coupled map lattices. We show that,
in some cases, these systems can produce completely unpredictable dynamics. In
a similar fashion, we explain why some wellknown spatiotemporal systems have
been found to produce very complex dynamics in numerical simulations. We
discuss real physical systems that can generate random dynamics.Comment: Accepted in International Journal of Bifurcation and Chao
Genetic analysis of four consanguineous multiplex families with inflammatory bowel disease
Background: Family studies support a genetic predisposition to inflammatory bowel diseases (IBD), but known genetic variants only partially explain the disease heritability. Families with multiple affected individuals potentially harbour rare and high-impact causal variants. Long regions of homozygosity due to recent inbreeding may increase the risk of individuals bearing homozygous loss-of-function variants. This study aimed to identify rare and homozygous genetic variants contributing to IBD. Methods: Four families with known consanguinity and multiple cases of IBD were recruited. In a family-specific analysis, we utilised homozygosity mapping complemented by whole-exome sequencing. Results: We detected a single region of homozygosity shared by Crohn's disease cases from a family of Druze ancestry, spanning 2.6 Mb containing the NOD2 gene. Whole-exome sequencing did not identify any potentially damaging variants within the region, suggesting that non-coding variation may be involved. In addition, affected individuals in the families harboured several rare and potentially damaging homozygous variants in genes with a role in autophagy and innate immunity including LRRK1, WHAMM, DENND3, and C5. Conclusion: This study examined the potential contribution of rare, high-impact homozygous variants in consanguineous families with IBD. While the analysis was not designed to achieve statistical significance, our findings highlight genes or loci that warrant further research. Non-coding variants affecting NOD2 may be of importance in Druze patients with Crohn's disease
Longitudinal morphological and functional characterization of human heart organoids using optical coherence tomography
Organoids play an increasingly important role as in vitro models for studying organ development, disease mechanisms, and drug discovery. Organoids are self-organizing, organ-like three-dimensional (3D) cell cultures developing organ-specific cell types and functions. Recently, three groups independently developed self-assembling human heart organoids (hHOs) from human pluripotent stem cells (hPSCs). In this study, we utilized a customized spectral-domain optical coherence tomography (SD-OCT) system to characterize the growth of hHOs. Development of chamber structures and beating patterns of the hHOs were observed via OCT and calcium imaging. We demonstrated the capability of OCT to produce 3D images in a fast, label-free, and non-destructive manner. The hHOs formed cavities of various sizes, and complex interconnections were observed as early as on day 4 of differentiation. The hHOs models and the OCT imaging system showed promising insights as an in vitro platform for investigating heart development and disease mechanisms
Cauchy-perturbative matching and outer boundary conditions: computational studies
We present results from a new technique which allows extraction of
gravitational radiation information from a generic three-dimensional numerical
relativity code and provides stable outer boundary conditions. In our approach
we match the solution of a Cauchy evolution of the nonlinear Einstein field
equations to a set of one-dimensional linear equations obtained through
perturbation techniques over a curved background. We discuss the validity of
this approach in the case of linear and mildly nonlinear gravitational waves
and show how a numerical module developed for this purpose is able to provide
an accurate and numerically convergent description of the gravitational wave
propagation and a stable numerical evolution.Comment: 20 pages, RevTe
Evolution of the Schr\"odinger--Newton system for a self--gravitating scalar field
Using numerical techniques, we study the collapse of a scalar field
configuration in the Newtonian limit of the spherically symmetric
Einstein--Klein--Gordon (EKG) system, which results in the so called
Schr\"odinger--Newton (SN) set of equations. We present the numerical code
developed to evolve the SN system and topics related, like equilibrium
configurations and boundary conditions. Also, we analyze the evolution of
different initial configurations and the physical quantities associated to
them. In particular, we readdress the issue of the gravitational cooling
mechanism for Newtonian systems and find that all systems settle down onto a
0--node equilibrium configuration.Comment: RevTex file, 19 pages, 26 eps figures. Minor changes, matches version
to appear in PR
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