DETERMINANTS OF FIRMS’ PERFORMANCE IN THE NIGERIAN HYDROCARBON INDUSTRY: DOES INTELLECTUAL CAPITAL MATTER?

This study adopts the Pulic (2002) VAICTM approach as a measure of intellectual capital, to examine the role of intellectual capital in the financial performance of the oil and gas industry in Nigeria. With the aid of panel analysis framework, it was found that aggregated composites of intellectual capital (VAIC) perform less satisfactorily in influencing the financial performance of firms in the oil and gas industry. However, when VAICTM was disaggregated into human, relational, and structural capital efficiency, it was discovered that the positive effect of human capital on the financial performance of these firms was cancelled out by the negative effect of structural capital. However, the relational capital efficiency that could have improved the financial performance of these firms has no significant impact on these firms’ performance and, as such, is ultimately responsible for the insignificant overall effect of intellectual capital (VAIC) on the financial performance of firms in Nigeria’s oil and gas industry. One of the implications of these findings is that these firms place much emphasis on human assets and neglect intangible assets such as processes, patents, copyright, research and development, customer care, etc. Also, the current structural capital of the firms in this industry constitutes a drag on their financial performance. Thus, serious attention should be placed on the effective management of firms’ relational and structural capital efficiency in order to ensure a better financial return

Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep

Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of intravenously (IV) administered tramadol and its active metabolite O-desmethyltramadol (M1) and to assess the mechanical antinociceptive effects in sheep. In a prospective, randomized, blinded study, six healthy adult sheep were given 4 and 6\u2009mg/kg tramadol and saline IV in a cross-over design with a 2-week wash-out period. At predetermined time points blood samples were collected and physiological parameters and mechanical nociceptive threshold (MNT) values were recorded. The analytical determination of tramadol and M1 was performed using high performance liquid chromatography. Pharmacokinetic parameters fitted a two- and a non-compartmental model for tramadol and M1, respectively. Normally distributed data were analysed by a repeated mixed linear model. Plasma concentration vs. time profiles of tramadol and M1 were similar after the two doses. Tramadol and M1 plasma levels decreased rapidly in the systemic circulation, with both undetectable after 6\u2009h following drug administration. Physiological parameters did not differ between groups; MNT values were not statistically significant between groups at any time point. It was concluded that although tramadol and M1 concentrations in plasma were above the human minimum analgesic concentration after both treatments, no mechanical antinociceptive effects of tramadol were reported. Further studies are warranted to assess the analgesic efficacy of tramadol in sheep

On the monotonicity of scalar curvature in classical and quantum information geometry

We study the statistical monotonicity of the scalar curvature for the alpha-geometries on the simplex of probability vectors. From the results obtained and from numerical data we are led to some conjectures about quantum alpha-geometries and Wigner-Yanase-Dyson information. Finally we show that this last conjecture implies the truth of the Petz conjecture about the monotonicity of the scalar curvature of the Bogoliubov-Kubo-Mori monotone metric.Comment: 20 pages, 2 .eps figures; (v2) section 2 rewritten, typos correcte

Testing QCD factorisation and charming penguins in charmless B→PV{\boldsymbol{B\to PV}}

We try a global fit of the experimental branching ratios and CP-asymmetries of the charmless $B\to PV$ decays according to QCD factorisation. We find it impossible to reach a satisfactory agreement, the confidence level (CL) of the best fit is smaller than .1 %. The main reason for this failure is the difficulty to accomodate several large experimental branching ratios of the strange channels. Furthermore, experiment was not able to exclude a large direct CP asymmetry in $\bar {B^0}\to\rho^+ \pi^-$, which is predicted very small by QCD factorisation. Trying a fit with QCD factorisation complemented by a charming-penguin inspired model we reach a best fit which is not excluded by experiment (CL of about 8 %) but is not fully convincing. These negative results must be tempered by the remark that some of the experimental data used are recent and might still evolve significantly.Comment: 21 pages, 4 figures; several typos corrected, added one footnote and two references, comments added about PQCD. To appear in Phys.Rev.

Charming penguin contributions to B => K \pi

We present calculations of the charming-penguin long-distance contributions to B => K \pi decays due to intermediate charmed meson states. Our calculation is based on the Chiral Effective Lagrangean for light and heavy mesons, corrected for the hard pion and kaon momenta. We find that the charming-penguin contributions increase significantly the B => K \pi decay rates in comparison with the short-distance contributions, giving results in better agreement with experimental data.Comment: 13 pages LaTeX (uses RevTeX and epsfig), 3 figures. Corrected typos. To appear in Physical Review

Ultra-High Energy Cosmic Rays in a Structured and Magnetized Universe

We simulate propagation of cosmic ray nucleons above 10^{19} eV in scenarios where both the source distribution and magnetic fields within about 50 Mpc from us are obtained from an unconstrained large scale structure simulation. We find that consistency of predicted sky distributions with current data above 4 x 10^{19} eV requires magnetic fields of ~0.1 microGauss in our immediate environment, and a nearby source density of ~10^{-4}-10^{-3} Mpc^{-3}. Radio galaxies could provide the required sources, but only if both high and low-luminosity radio galaxies are very efficient cosmic ray accelerators. Moreover, at ~10^{19} eV an additional isotropic flux component, presumably of cosmological origin, should dominate over the local flux component by about a factor three in order to explain the observed isotropy. This argues against the scenario in which local astrophysical sources of cosmic rays above ~10^{19} eV reside in strongly magnetized (B~0.1 microGauss) and structured intergalactic medium. Finally we discuss how future large scale full-sky detectors such as the Pierre Auger project will allow to put much more stringent constraints on source and magnetic field distributions.Comment: 11 revtex pages, 10 postscript figures included, final version to appear in PR

Elastic and inelastic SU(3)-breaking final-state interactions in B decays to pseudoscalar mesons

We discuss all contributions from Zweig-rule-satisfying SU(3)-breaking final state interactions (FSIs)in the B -> PP decays (neglecting charmed intermediate states), where PP=pi pi, pi K, KK, pi eta (eta'), and K eta (eta'). First, effects of SU(3) breaking in rescattering through Pomeron exchange are studied. Then, after making a plausible assumption concerning the pattern of SU(3) breaking in non-Pomeron FSIs, we give general formulas for how the latter modify short-distance (SD) amplitudes. In the SU(3) limit, these formulas depend on three effective parameters characterizing the strength of all non-Pomeron rescattering effects. We point out that the experimental bounds on the B -> K^+K^- branching ratio may limit the value of only one of these FSI parameters. Thus, the smallness of the B -> K^+K^- decay rate does not imply negligible rescattering effects in other decays. Assuming a vanishing value of this parameter, we perform various fits to the available B -> PP branching ratios. The fits determine the quark-diagram SD amplitudes, the two remaining FSI parameters and the weak angle gamma. While the set of all B -> PP branching ratios is well described with gamma around its expected SM value, the fits permit other values of gamma as well. For a couple of such good fits, we predict asymmetries for the B -> K pi, pi^+ eta (eta'), K^+ eta (eta') decays as well as the values of the CP-violating parameters S_{pi pi} and C_{pi pi} for the time-dependent rate of B^0(t) -> pi^+ pi^-. Apart from a problem with the recent B^+ -> pi^+ eta asymmetry measurement, comparison with the data seems to favour the values of gamma in accordance with SM expectations.Comment: 27 pages, 5 figure

Donor Lymphocyte Infusions After Allogeneic Stem Cell Transplantation in Acute Leukemia: A Survey From the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

We conducted a retrospective multicenter study including pediatric and adult patients with acute leukemia (AL) who received donor lymphocyte infusions (DLIs) after allogeneic hematopoietic stem cell transplantation (HCT) between January 1, 2010 and December 31, 2015, in order to determine the efficacy and toxicity of the immune treatment. Two hundred fifty-two patients, median age 45.1 years (1.6\u201373.4), were enrolled from 34 Italian transplant centers. The underlying disease was acute myeloid leukemia in 180 cases (71%). Donors were HLA identical or 1 locus mismatched sibling (40%), unrelated (40%), or haploidentical (20%). The first DLI was administered at a median time of 258 days (55\u20133,784) after HCT. The main indication for DLI was leukemia relapse (73%), followed by mixed chimerism (17%), and pre-emptive/prophylactic use (10%). Ninety-six patients (38%) received one single infusion, whereas 65 (26%), 42 (17%), and 49 patients (19%) received 2, 3, or 654 infusions, respectively, with a median of 31 days between two subsequent DLIs. Forty percent of evaluable patients received no treatment before the first DLI, whereas radiotherapy, conventional chemotherapy or targeted treatments were administered in 3, 39, and 18%, respectively. In informative patients, a few severe adverse events were reported: grade III\u2013IV graft versus host disease (GVHD) (3%), grade III\u2013IV hematological toxicity (11%), and DLI-related mortality (9%). Forty-six patients (18%) received a second HCT after a median of 232 days (32\u20131,390) from the first DLI. With a median follow-up of 461 days (2\u20133,255) after the first DLI, 1-, 3-, and 5- year overall survival (OS) of the whole group from start of DLI treatment was 55, 39, and 33%, respectively. In multivariate analysis, older recipient age, and transplants from haploidentical donors significantly reduced OS, whereas DLI for mixed chimerism or as pre-emptive/prophylactic treatment compared to DLI for AL relapse and a schedule including more than one DLI significantly prolonged OS. This GITMO survey confirms that DLI administration in absence of overt hematological relapse and multiple infusions are associated with a favorable outcome in AL patients. DLI from haploidentical donors had a poor outcome and may represent an area of further investigation

Deciphering a subgroup of breast carcinomas with putative progression of grade during carcinogenesis revealed by comparative genomic hybridisation (CGH) and immunohistochemistry

Distinct parallel cytogenetic pathways in breast carcinogenesis could be identified in recent years. Nevertheless, it remained unclear as to which tumours may have progressed in grade or which patterns of cytogenetic alteration may define the switch from an in situ towards an invasive lesion. In order to gain more detailed insights into cytogenetic mechanisms of the pathogenesis of breast cancer, the chromosomal imbalances of 206 invasive breast cancer cases were characterised by means of comparative genomic hybridisation (CGH). CGH data were subjected to hierarchical cluster analysis and the results were further compared with immunohistochemical findings on tissue arrays from the same breast cancer cases. The combined analysis of immunohistochemical and cytogenetic data provided evidence that carcinomas with gains of 7p, and to a lesser extent losses of 9q and gains of 5p, are a distinct subgroup within the spectrum of ductal invasive grade 3 breast carcinomas. These aberrations were associated with a high degree of cytogenetic instability (16.6 alterations per case on average), 16q-losses in over 70% of these cases, strong oestrogen receptor expression and absence of strong expression of p53, c-erbB2 and Ck 5. These characteristics provide strong support for the hypothesis that these tumours may develop through stages of well- and perhaps intermediately differentiated breast cancers. Our results therefore underline the existence of several parallel and also stepwise progression pathways towards breast cancer