112 research outputs found
Contrasting histoarchitecture of calcified leaflets from stenotic bicuspid versus stenotic tricuspid aortic valves
AbstractPreliminary findings from clinical trials of percutaneous balloon aortic valvuloplasty and intraoperative debridement of calcific deposits in patients with aortic stenosis have suggested that calcified, congenitally bicuspid aortic valves may be less amenable to these techniques than are calcified tricuspid aortic valves. Accordingly, we evaluated the histoarchitecture of calcific deposits in 30 operatively excised aortic valves. Light microscopic sections taken through the calcified aortic valve leaflets disclosed two principal types of histoarchitectitre. In 11 aortic valves nodular calcific deposits were superimposed on an underlying fibrotic aortic valve leaflet (type A); in 17 valves calcific deposits were diffusely distributed throughout the body (spongiosa) of the aortic valve leaflets (type B). Two aortic valves could not be classified histologically.These histologic subtypes were not randomly distributed with regard to gross valvular morphology. All 14 bicuspid valves (100%) were type B; in contrast, 11 (69%) of 16 tricuspld aortic valves were type A, and only 3 (19%) of 16 tricuspid valves were type B (p < 0.01). Both valves with nonclassifiable histologic features were tricuspid on the basis of gross examination.Thus, the histoarchitectural distribution of calcific deposits is different for bicuspid than for tricuspid stenotic aortic valves. The more diffuse distribution of calcium throughout the body of calcified bicuspid aortic valve leaflets may render these valves less amenable to operative and percutaneous valvuloplasty than are calcified tricuspid aortic valve leaflets on which calcific deposits are typically superimposed in nodular form
Intravascular ultrasound of renal arteries in patients undergoing percutaneous transluminal angioplasty: Feasibility, safety and initial findings, including 3 dimensional reconstruction of renal arteries
Accelerated re-endothelialization and reduced neointimal thickening following catheter transfer of phVEGF165
Low level laser energy delivered percutaneously in vivo reverses spasm induced by administration of intraarterial histamine to atherosclerotic microswine
3-dimensional intravascular ultrasound imaging of human coronary arteries after percutaneous revascularization
Is doppler ultrasound accurate in screening for restenosis after carotid artery stenting? A comparison with quantitative carotid anglography
Transesophageal echocardiographic guidance during percutaneous laser myoplasty for hypertrophic cardiomyopathy: Results of a canine trial
- …