Precision Medicine Informatics: Principles, Prospects, and Challenges

Precision Medicine (PM) is an emerging approach that appears with the impression of changing the existing paradigm of medical practice. Recent advances in technological innovations and genetics, and the growing availability of health data have set a new pace of the research and imposes a set of new requirements on different stakeholders. To date, some studies are available that discuss about different aspects of PM. Nevertheless, a holistic representation of those aspects deemed to confer the technological perspective, in relation to applications and challenges, is mostly ignored. In this context, this paper surveys advances in PM from informatics viewpoint and reviews the enabling tools and techniques in a categorized manner. In addition, the study discusses how other technological paradigms including big data, artificial intelligence, and internet of things can be exploited to advance the potentials of PM. Furthermore, the paper provides some guidelines for future research for seamless implementation and wide-scale deployment of PM based on identified open issues and associated challenges. To this end, the paper proposes an integrated holistic framework for PM motivating informatics researchers to design their relevant research works in an appropriate context.Comment: 22 pages, 8 figures, 5 tables, journal pape

Exploring post-COVID-19 health effects and features with advanced machine learning techniques

COVID-19 is an infectious respiratory disease that has had a significant impact, resulting in a range of outcomes including recovery, continued health issues, and the loss of life. Among those who have recovered, many experience negative health effects, particularly influenced by demographic factors such as gender and age, as well as physiological and neurological factors like sleep patterns, emotional states, anxiety, and memory. This research aims to explore various health factors affecting different demographic profiles and establish significant correlations among physiological and neurological factors in the post-COVID-19 state. To achieve these objectives, we have identified the post-COVID-19 health factors and based on these factors survey data were collected from COVID-recovered patients in Bangladesh. Employing diverse machine learning algorithms, we utilised the best prediction model for post-COVID-19 factors. Initial findings from statistical analysis were further validated using Chi-square to demonstrate significant relationships among these elements. Additionally, Pearson’s coefficient was utilized to indicate positive or negative associations among various physiological and neurological factors in the post-COVID-19 state. Finally, we determined the most effective machine learning model and identified key features using analytical methods such as the Gini Index, Feature Coefficients, Information Gain, and SHAP Value Assessment. And found that the Decision Tree model excelled in identifying crucial features while predicting the extent of post-COVID-19 impact

Multimodal fusion for audio-image and video action recognition

Multimodal Human Action Recognition (MHAR) is an important research topic in computer vision and event recognition fields. In this work, we address the problem of MHAR by developing a novel audio-image and video fusion-based deep learning framework that we call Multimodal Audio-Image and Video Action Recognizer (MAiVAR). We extract temporal information using image representations of audio signals and spatial information from video modality with the help of Convolutional Neutral Networks (CNN)-based feature extractors and fuse these features to recognize respective action classes. We apply a high-level weights assignment algorithm for improving audio-visual interaction and convergence. This proposed fusion-based framework utilizes the influence of audio and video feature maps and uses them to classify an action. Compared with state-of-the-art audio-visual MHAR techniques, the proposed approach features a simpler yet more accurate and more generalizable architecture, one that performs better with different audio-image representations. The system achieves an accuracy 87.9% and 79.0% on UCF51 and Kinetics Sounds datasets, respectively. All code and models for this paper will be available at https://tinyurl.com/4ps2ux6n

AEF : Adaptive en-route filtering to extend network lifetime in wireless sensor networks

Funding Information: This work was supported by National Research Foundation of Korea-Grant funded by the Korean Government (Ministry of Science and ICT)-NRF-2017R1A2B2012337). This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (Ministry of Science and ICT) NRF-2017R1A2B2012337). Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.Peer reviewe

Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro­phen­yl)-2-hydro­peroxy-4-hydr­oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo­[3.1.0]hexane-1-carboxamide

The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C26H24FNO6, which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter­molecular hydrogen bonding is found

PyMAiVAR: An open-source Python suit for audio-image representation in human action recognition

We present PyMAiVAR, a versatile toolbox that encompasses the generation of image representations for audio data including Wave plots, Spectral Centroids, Spectral Roll Offs, Mel Frequency Cepstral Coefficients (MFCC), MFCC Feature Scaling, and Chromagrams. This wide-ranging toolkit generates rich audio-image representations, playing a pivotal role in reshaping human action recognition. By fully exploiting audio data\u27s latent potential, PyMAiVAR stands as a significant advancement in the field. The package is implemented in Python and can be used across different operating systems

SAM-SoS: A stochastic software architecture modeling and verification approach for complex System-of-Systems

A System-of-Systems (SoS) is a complex, dynamic system whose Constituent Systems (CSs) are not known precisely at design time, and the environment in which they operate is uncertain. SoS behavior is unpredictable due to underlying architectural characteristics such as autonomy and independence. Although the stochastic composition of CSs is vital to achieving SoS missions, their unknown behaviors and impact on system properties are unavoidable. Moreover, unknown conditions and volatility have significant effects on crucial Quality Attributes (QAs) such as performance, reliability and security. Hence, the structure and behavior of a SoS must be modeled and validated quantitatively to foresee any potential impact on the properties critical for achieving the missions. Current modeling approaches lack the essential syntax and semantics required to model and verify SoS behaviors at design time and cannot offer alternative design choices for better design decisions. Therefore, the majority of existing techniques fail to provide qualitative and quantitative verification of SoS architecture models. Consequently, we have proposed an approach to model and verify Non-Deterministic (ND) SoS in advance by extending the current algebraic notations for the formal models as a hybrid stochastic formalism to specify and reason architectural elements with the required semantics. A formal stochastic model is developed using a hybrid approach for architectural descriptions of SoS with behavioral constraints. Through a model-driven approach, stochastic models are then translated into PRISM using formal verification rules. The effectiveness of the approach has been tested with an end-to-end case study design of an emergency response SoS for dealing with a fire situation. Architectural analysis is conducted on the stochastic model, using various qualitative and quantitative measures for SoS missions. Experimental results reveal critical aspects of SoS architecture model that facilitate better achievement of missions and QAs with improved design, using the proposed approach

Cyber Threat Predictive Analytics for Improving Cyber Supply Chain Security

Cyber Supply Chain (CSC) system is complex which involves different sub-systems performing various tasks. Security in supply chain is challenging due to the inherent vulnerabilities and threats from any part of the system which can be exploited at any point within the supply chain. This can cause a severe disruption on the overall business continuity. Therefore, it is paramount important to understand and predicate the threats so that organization can undertake necessary control measures for the supply chain security. Cyber Threat Intelligence (CTI) provides an intelligence analysis to discover unknown to known threats using various properties including threat actor skill and motivation, Tactics, Techniques, and Procedure (TT and P), and Indicator of Compromise (IoC). This paper aims to analyse and predicate threats to improve cyber supply chain security. We have applied Cyber Threat Intelligence (CTI) with Machine Learning (ML) techniques to analyse and predict the threats based on the CTI properties. That allows to identify the inherent CSC vulnerabilities so that appropriate control actions can be undertaken for the overall cybersecurity improvement. To demonstrate the applicability of our approach, CTI data is gathered and a number of ML algorithms, i.e., Logistic Regression (LG), Support Vector Machine (SVM), Random Forest (RF), and Decision Tree (DT), are used to develop predictive analytics using the Microsoft Malware Prediction dataset. The experiment considers attack and TTP as input parameters and vulnerabilities and Indicators of compromise (IoC) as output parameters. The results relating to the prediction reveal that Spyware/Ransomware and spear phishing are the most predictable threats in CSC. We have also recommended relevant controls to tackle these threats. We advocate using CTI data for the ML predicate model for the overall CSC cyber security improvement

A software agent enabled biometric security algorithm for secure file access in consumer storage devices

In order to resist unauthorized access, consumer storage devices are typically protected using a low entropy password. However, storage devices are not fully protected against an adversary because the adversary can utilize an off-line dictionary attack to find the correct password and/or run an existing algorithm for resetting the existing password. In addition, a password protected device may also be stolen or misplaced allowing an adversary to easily retrieve all the stored confidential information from a removable storage device. In order to protect the consumer’s confidential information that has been stored, this paper proposes a mutual authentication and key negotiation protocol that can be used to protect the confidential information in the device. The functionality of the protocol enables the storage device to be secure against relevant security attacks. A formal security analysis using Burrows-Abadi-Needham (BAN) logic is presented to verify the presented algorithm. In addition, a performance analysis of the proposed protocol reveals a significantly reduced communication overhead compared to the relevant literature

Gafor : Genetic algorithm based fuzzy optimized re-clustering in wireless sensor networks

Acknowledgments: The authors are grateful to the Deanship of Scientific Research at King Saud University for funding this work through Vice Deanship of Scientific Research Chairs: Chair of Pervasive and Mobile Computing. Funding: This research was funded by King Saud University in 2020.Peer reviewedPublisher PD