Kansei analysis shown in a single map: multiple correspondence analysis of design elements and Kansei evaluation

In this study, we regarded the idea that supplementary variables and Multiple Correspondence Analysis are promising for analysis and visualize complicated relations in Kansei analysis. It could merge several different information tables and then project them into a map. Applying this advantage would make the overall view of Kansei. Design elements, samples, and associated Kansei words were shown in an MCA map. Leather patterns of children’s lower leg orthotics are the objective of this Kansei evaluation. The leather surface was simulated with 3D CG with physically based rendering methods

Finite Element Estimation of Pressure Distribution inside the Trunk on a Mattress

We developed a bedsore-prevention mattress and wheel chair cushion. Throughout development, we made numerous body pressure measurements on different mattresses and cushions. Such measurements required much time and effort. Simulation of body pressure has the potential to estimate the pressure distribution caused by physical parameters of different mattresses. In this study, we show attempts to model the body and estimate the pressure on its transverse plane. The computation was based on a non-linear finite element method with hyperelastic materials, such as muscle, skin and fat. Because the model simulates different tissues, we can estimate the pressure not only on the surface, but also that inside the trunk. The simulated results agreed well with actual pressure measurement results. Differences in physical properties of the mattresses were also modeled

Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes

AbstractArginine residue at position 285 (R285) in the intracellular C-terminal domain of inward rectifier potassium channel Kir2.2 is conserved in many species, but missing in previously reported human Kir2.2 sequences. We here identified the human Kir2.2 gene in normal individuals, which contained R285 in the deduced amino-acid sequence (hKir2.2/R285). All 30 individuals we examined were homozygous for Kir2.2/R285 gene. The hKir2.2/R285 was electrophysiologically functional in both mammalian cells and Xenopus oocytes. However, the hKir2.2 missing R285 was functional only in Xenopus oocytes, but not in mammalian cells. Thus, R285 in Kir2.2 is important for its functional expression in mammalian cells

産後6か月間におけるうつ・不安症状の経過と新生児と関わる時の感情との関連

Background: Depressive symptoms and anxiety symptoms during the postpartum period affect physical health and child rearing and that these effects are important social issues. Objective: The aims of this study were to clarify the differences in the transition of depressive symptoms and anxiety symptoms according to parity during a 6-month postpartum period and to clarify the differences in associations of depressive symptoms and anxiety symptoms with feelings for involvement with newborn infants in primiparous and multiparous postpartum women. Methods: The design of this study was a longitudinal investigation. This study was conducted from February 2017 to July 2018 in Japan. By using self-administered questionnaires that included questions on psychological symptoms in a standard climacteric scale and questions on feelings for involvement with newborn infants, we collected data at 3 days postpartum, 2 weeks postpartum, one month postpartum, 3 months postpartum and 6 months postpartum. Results: Responses to all of the questionnaires were obtained from 121 (52.8%) of 229 women. The score for depressive symptoms in primiparous women was significantly higher than that in multiparous women at 3 days postpartum. Depressive symptoms and anxiety symptoms showed peaks at 2 weeks postpartum in both primiparous women and multiparous women, but depressive symptoms reoccurred from 3 months postpartum to 6 months postpartum in primiparous women and anxiety symptoms reoccurred from one month to 3 months postpartum in multiparous women. Depressive symptoms and anxiety symptoms were associated with negative feelings for involvement with newborn infants and with mother’s sleeping time. Conclusion: Changes in depressive symptoms and anxiety symptoms were different in primiparous women and multiparous women during a 6-month postpartum period. In addition, depressive symptoms and anxiety symptoms were associated with negative feelings for involvement with newborn infants and with sleeping time in postpartum women

Prevalence and factors related to hot flashes and night sweats in postpartum women in Japan

Hot flashes and night sweats commonly occur during menopausal transition period due to estrogen deficiency, but these conditions can also occur during postpartum period in which there are marked hormonal fluctuations. This study determined the prevalence and examined factors related to hot flashes and night sweats among the Japanese women in the postpartum period. The design of this study was a longitudinal investigation and the population of the postpartum women recruited was 229. A self-administered questionnaire that adapted Edinburgh Postnatal Depression Scale (EPDS) of measurement was used to collect data at 3 days postpartum, 2 weeks postpartum and one month postpartum. There was a significant association between transient night sweats and anxiety regarding family finances. Women who complained of hot flashes was 22.8% at 3 days postpartum and it decreased thereafter, while women who complained of night sweats were 58.6% at 3 days postpartum, 33.1% at 2 weeks postpartum and 15.2% at one month postpartum. In conclusion, hot flashes and night sweats among Japanese women in the postpartum period was associated with psychological and social factors

Effect of cyclic bis(3′–5′)diguanylic acid and its analogs on bacterial biofilm formation

Cyclic bis(3′–5′)diguanylic acid (cyclic-di-GMP) functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes. We measured cyclic-di-GMP and its structural analogs such as cyclic bis(3′–5′)guanylic/adenylic acid (cyclic-GpAp), cyclic bis(3′–5′)guanylic/inosinic acid (cyclic-GpIp) and monophosphorothioic acid of cyclic-di-GMP (cyclic-GpGps) for effects on the biofilm formation of Staphylococcus aureus and Pseudomonas aeruginosa. We constructed a knockout mutant of SA0701, which is a GGDEF motif protein relevant to diguanylate cyclase from S. aureus 2507. We confirmed that the biofilm formation of this mutant (MS2507ΔSA0701) was reduced. Cyclic-di-GMP corresponding to physiological intracellular levels given in the culture recovered the biofilm formation of MS2507ΔSA0701, whereas its analogs did not, indicating that unlike a previous suggestion, cyclic-di-GMP was involved in the positive regulation of the biofilm formation of S. aureus and its action was structurally specific. At a high concentration (200 μM), cyclic-di-GMP and its analogs showed suppression effects on the biofilm formation of S. aureus and P. aeruginosa, and according to the quantification study using costat analysis, the suppression potential was in the order of cyclic-di-GMP, cyclic-GpGps, cyclic-GpAp and cyclic-GpIp, suggesting that the suppression effect was not strictly specific and the change of base structure quantitatively affected the suppression activity