Convolutional Neural Networkを使用した物質乱流拡散漏洩源推定に関する研究

東京理科大学202

Intracoronary Autologous Cardiac Progenitor Cell Transfer in Patients With Hypoplastic Left Heart Syndrome (TICAP) : A Prospective Phase 1 Controlled Trial

RATIONALE: Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function. OBJECTIVE: The aim of this study was to test whether intracoronary delivery of CDCs is feasible and safe in patients with hypoplastic left heart syndrome. METHODS AND RESULTS: Between January 5, 2011, and January 16, 2012, 14 patients (1.8±1.5 years) were prospectively assigned to receive intracoronary infusion of autologous CDCs 33.4±8.1 days after staged procedures (n=7), followed by 7 controls with standard palliation alone. The primary end point was to assess the safety, and the secondary end point included the preliminary efficacy to verify the right ventricular ejection fraction improvements between baseline and 3 months. Manufacturing and intracoronary delivery of CDCs were feasible, and no serious adverse events were reported within the 18-month follow-up. Patients treated with CDCs showed right ventricular ejection fraction improvement from baseline to 3-month follow-up (46.9%±4.6% to 52.1%±2.4%; P=0.008). Compared with controls at 18 months, cardiac MRI analysis of CDC-treated patients showed a higher right ventricular ejection fraction (31.5%±6.8% versus 40.4%±7.6%; P=0.049), improved somatic growth (P=0.0005), reduced heart failure status (P=0.003), and lower incidence of coil occlusion for collaterals (P=0.007). CONCLUSIONS: Intracoronary infusion of autologous CDCs seems to be feasible and safe in children with hypoplastic left heart syndrome after staged surgery. Large phase 2 trials are warranted to examine the potential effects of cardiac function improvements and the long-term benefits of clinical outcomes

IHTC14-23138 INFLUENCE OF RHEOLOGICAL PARAMETERS ON TURBULENT HEAT TRANSFER IN DRAG-REDUCING VISCOELASTIC CHANNEL FLOW IHTC14

ABSTRACT Direct numerical simulations (DNS) of a drag-reducing viscoelastic turbulent channel flow with heat transfer had been carried out for three kinds of rheologically different fluids (e.g., different values of Weissenberg number). The molecular Prandtl number was set to be 0.1-2.0. A uniform heat-flux condition was employed as the thermal boundary condition. In this paper, we present various statistical turbulence quantities including the mean and fluctuating temperatures, the Nusselt number (Nu), and the cross-correlation coefficients and discuss about their dependence on the rheological parameters and the Prandtl-number dependency of the obtained drag-reduction rate and heat-transfer reduction rate. NOMENCLATURE We τ Weissenberg number, = ρu 2 τ δλ/η s x, y, z streamwise, wall-normal and spanwise direction α anisotropic mobility factor β ratio of shear viscosities, = η a /η 0 δ channel half width η 0 solution shear viscosity at zero-shear rate, = η s + η a η a shear viscosity of additive contribution η eff effective viscosity at the wall η s shear viscosity of solvent contribution λ relaxation time θ temperature θ m bulk mean temperature τ w mean wall shear stress INTRODUCTION As well known for sixty years, the turbulent friction drag could be reduced by up to 80% through the addition of minute amounts of polymers or surfactants to water. This observation by Toms [1] triggered a large number of studies to characterize this phenomenon. In spite of this long history, neither fully satisfactory theory nor good prediction method of drag reduction (DR) is available yet. There exist several reviews [2-4] provide some highlights of the progress in understanding of this subject. With a recent development of computers, a direct numerical simulation (DNS) has become an important tool to investigate the drag reducing turbulent channel flow of viscoelastic fluids In this paper, we present the results of an extensive DNS investigation of the turbulent channel flow of viscoelastic fluids accompanied by heat transfer, using Giesekus model. To investigate the Prandtl-number dependence of the heat transfer in drag-reducing flow, the Pr was set to be 0.1-2.0. In our previous stud

Experimental study on measurement method of gravel discharge rate in highspeed flow using plate-type sensor

[2nd International Workshop on Sediment Bypass Tunnels = 第2回排砂バイパストンネルに関する国際ワークショップ] May 9-12, Kyoto-Japan, 2017.特定研究集会: 29C-01A sediment bypass tunnel is used as one of the methods of sediment management for reducing the sedimentation of the dam reservoir and conserving and improving the sediment transport downstream of the dam. Measurement of the amount of sediment passing through the sediment bypass tunnel is important for operation and maintenance of the facility concerning abrasion damage, examination and evaluation of riverbed environmental change of the downstream river. Therefore, considering the application to the Koshibu Dam sediment bypass tunnel, the authors are investigating measurement method of gravel flow amount in high-speed flow. The sediment bypass tunnel began test operation in the autumn of 2016 at the Koshibu Dam built in the Koshibu River, the tributary of the Tenryu River in Japan. In this paper, the authors report the results of examining the response characteristics and measurement method of the plate-type sensor against gravel flow by the flume experiment reproducing high speed flow of about 10 m/s

Broadened quantum critical ground state in a disordered superconducting thin film

Abstract A superconductor-insulator transition (SIT) in two dimensions is a prototypical quantum phase transition (QPT) with a clear quantum critical point (QCP) at zero temperature (T = 0). The SIT is induced by a field B and observed in disordered thin films. In some of weakly disordered or crystalline thin films, however, an anomalous metallic (AM) ground state emerges over a wide B range between the superconducting and insulating phases. It remains a fundamental open question how the QPT picture of the SIT is modified when the AM state appears. Here we present measurements of the Nernst effect N, which has great sensitivity to the fluctuations of the superconducting order parameter. From a thorough contour map of N in the B-T plane, we found a thermal-to-quantum crossover line of the superconducting fluctuations, a so-called ghost-temperature line associated with the QPT, as well as a ghost-field line associated with a thermal transition. The QCP is identified as a T = 0 intercept of the ghost-temperature line inside the AM state, which verifies that the AM state is a broadened critical state of the SIT