Застосування методу екологічної оцінки будівельних матеріалів при порівнянні різних аспектів впливу на навколишнє середовище

This article discusses the methods of environmental assessment of building materials in terms of their hygienic safety, identifies these safety criteria and characteristics to assess the impact of building materials on human health. On their basis, we developed ecological ways to improve the sanitary and hygienic properties of finishing materials.У даній статті розглянуті методи екологічної оцінки будівельних матеріалів за показниками їх гігієнічної безпеки, визначені ці критерії безпеки і характеристики для оцінки впливу будівельних матеріалів на здоров’я людини. На їх основі розробили екологічні шляхи покращення санітарно-гігієнічних властивостей оздоблювальних матеріалів

Photoelectric and Spectral Properties of Composite Films based on GCBE-Oligomer with Different Concentrations of Polymethine Dyes

Thin film of composites based on N-epoxypropylcarbazole and n-butylglycidyl ether co-oligomer (GCBE) sensitized by various concentrations of cationic polymethine dyes with different polymethine chain length have been prepared. Their photophysical, electrical, and spectral properties have been investigated. All studied composite films have been shown to exhibited photoconductivity effect. In film composites with high concentration of the dye photovoltaic effect have been detected. The diffusion nature of this effect and its features correlation with electronic properties of PCFs components has been established

ОСОБЛИВОСТІ ПЕРИНАТАЛЬНОГО АНАМНЕЗУ В ДІТЕЙ З БРОНХОЛЕГЕНЕВОЮ ДИСПЛАЗІЄЮ НА СУЧАСНОМУ ЕТАПІ.

Bronchopulmonary dysplasia - one of the pressing problems of Pediatrics, whose significance goes beyond the neonatal and is considered a chronic obstructive disease of young children. The paper presented the results of the study perinatalanamneses of children with bronchopulmonary dysplasia.Бронхолегочная дисплазия - одна из актуальных проблем педиатрии, значение которой выходит за пределы неонатологии и рассматривается как хроническое обструктивное заболевание детей раннего возраста. В работе представлены результаты изучения особенностей перинатального анамнеза у детей с бронхолегочной дисплазией. Бронхолегенева дисплазія - одна з актуальних проблем педіатрії, значення якої виходить за межі неонатології і розглядається як хронічне обструктивне захворювання дітей раннього віку. В роботі подані результати вивчення особливостей перинатального анамнезу в дітей із бронхолегеневою дисплазією

Special features of high-speed interaction of supercavitating solids in water

Special features of material behavior of a supercavitating projectile are investigated at various initial velocities of entering water on the basis of the developed stress-strain state model with possibility of destruction of solids when moving in water and interacting with various underwater barriers with the use of consistent methodological approach of mechanics of continuous media. The calculation-experimental method was used to study the modes of motion of supercavitating projectiles at sub- and supersonic velocities in water medium after acceleration in the barrelled accelerator, as well as their interaction with barriers. Issues of stabilization of the supercavitating projectile on the initial flight path in water were studied. Microphotographs of state of solids made of various materials, before and after interaction with water, at subsonic and supersonic velocities were presented. Supersonic velocity of the supercavitating projectile motion in water of 1590 m/s was recorded

Evaluation of grain yield performance and its stability in various spring barley accessions under condition of different agroclimatic zones of Ukraine

Two extremely urgent problems of biological and agronomic research nowadays are ensuring an optimal balance between usage of natural resources to meet rapidly growing needs for food production and preservation of biodiversity. It is also important to extend the genetic diversity of the main crop varieties in agroecosystems. At the same time, modern varieties should be characterized by a combination of high yield and preserving yield stability under variable conditions. Solving the outlined tasks requires comprehensive research and involvement in breeding process of the genetical diversity concentrated in genebanks of the world. Barley (Hordeum vulgare L.) is one of the most important crops that satisfy the various needs of humanity. In respect to this, in 2020–2022, a multi-environment trial was conducted in three agroclimatic zones of Ukraine (Forest-Steppe, Polissia, and Northern Steppe). We studied 44 spring barley collection accessions of different ecological and geographical origin, different subspecies and groups of botanical varieties which were obtained from the National Center for Plant Genetic Resources of Ukraine. Statistical indices (Hom, Sc) and graphical models (GGE biplot, AMMI) were used to interpret the yield performance and its stability. Both individual ecological sites in different years and combinations of different sites and years of trials were characterized for productivity, discriminating power and representativeness. The environments differed quite strongly among themselves in terms of these indicators. It was established that most of the genotypes were characterized by higher adaptability to individual environmental conditions (stability in different years), compared to adaptability for all agroclimatic zones (wide adaptation). A strong cross-over genotype by environment interaction was found for most studied accessions. Nevertheless, both genotypes with very high stability in only one agroclimatic zone (Amil (UKR), Gateway (CAN)) and genotypes with a combination of high adaptability to one or two ecological niches and relatively higher wide adaptability (Stymul (UKR), Ly-1064 (UKR), Rannij (KAZ), Shedevr (UKR), and Arthur (CZE)) were identified. There were also the accessions which did not show maximum performance in the individual sites, but had relatively higher wide adaptability (Ly-1059 (UKR), Ly-1120 (UKR), Diantus (UKR), and Danielle (CZE)). In general, the naked barley genotypes were inferior to the covered ones in terms of yield potential and wide adaptability, but at the same time, some of them (CDC ExPlus (CAN), CDC Gainer (CAN), and Roseland (CAN)), accordingly to the statistical indicators, had increased stability in certain ecological sites. Among naked barley accessions relatively better wide adaptability according to the graphical analysis was found in the accession CDC McGwire (CAN), and by the statistical parameters CDC ExPlus (CAN) was better than standard. The peculiarities of yield manifestation and its variability in different spring barley genotypes in the multi-environment trial revealed in this study will contribute to the complementation and deepening of existing data in terms of the genotype by environment interaction. Our results can be used in further studies for developing spring barley variety models both with specific and wide adaptation under conditions of different agroclimatic zones of Ukraine. The disitnguished accessions of different origin and botanical affiliation are recommended for creating a new breeding material with the aim of simultaneously increasing yield potential and stability, as well as widening the genetic basis of spring barley varieties

Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes

Obesity and diabetes mellitus are known to lead to the development of metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). The mechanisms of programmed cell death are actively involved in maintaining cellular homeostasis along development of NAFLD. Proteins of the BCL-2 family are key regulators of physiological and pathological apoptosis. Homozygous males of BKS.Cg-Dock7mLeprdb/+/+/J mice (db/db mice) are characterized by progressive obesity and the development of type 2 diabetes mellitus (DM2) with severe hyperglycemia at 4–8 weeks and organ lesions at 8–10 weeks of age. The aim of this research was to study the expression of molecular cell regulators of apoptosis in liver cells of db/db mice males at different stages of obesity and diabetes development (at the age of 10 and 18 weeks). Immunohistochemical analysis (using the indirect avidin-biotin peroxidase method) and morphometric evaluation of the expression of the antiapoptotic protein Bcl-2 and the proapoptotic protein Bad in liver cells of studied animals at different stages of obesity and DM2 were carried out. An excess of the value of the Bcl-2 protein staining area over the Bad protein staining area was revealed in the liver of 10-week-old animals. The Bcl-2/Bad expression area ratio in 10-week-old animals was twice as high as in 18-week-old animals, which indicates the presence of conditions for blocking apoptosis in the liver of younger db/db mice. At the 18th week of life, db/db mice displayed an almost threefold increase in the expression area of the Bad protein against the background of an unchanged expression of the Bcl-2 protein. The decrease in the Bcl-2/Bad staining area ratio in 18-week-old animals was due to the increase in the Bad expression area, which indicates the absence of antiapoptotic cell protection and creates conditions for activation of the mitochondrial pathway of apoptosis in the liver of male db/db mice with pronounced signs of obesity and DM2

The expression of apoptosis-regulating proteins Bcl-2 and Bad in liver cells of C57Bl/6 mice under light-induced functional pinealectomy and after correction with melatonin

The presence of humans and animals under long-term continuous lighting leads to a suppression of melatonin synthesis, that is, to light-induced functional pinealectomy (LIFP), and the development of desynchronosis. To create LIFP, C57Bl/6 mice were kept under 24-hour lighting (24hL) for 14 days. The animals in the control group were kept under standard lighting conditions. In the next series of experiments, mice with LIFP received daily intragastrically either melatonin (1 mg/kg body weight in 200 μl of distilled water) or 200 μl of water as a placebo. The comparison group consisted of intact animals that received placebo under standard lighting conditions. Immunohistochemical analysis (using an indirect avidin-biotin peroxidase method) revealed the expression of the antiapoptotic protein Bcl-2 and the proapoptotic protein Bad in sinusoid liver cells (a heterogeneous population consisting of the endotheliocytes, Kupffer cells, Ito cells, and Pit cells) and in individual hepatocytes. The Bad expression area in the liver of LIFP mice increased 4 times against a background of the unchanged Bcl-2 expression area. Changes in the brightness (a parameter inversely proportional to the marker concentration) of Bad and Bcl-2 areas did not reach significance. Our results indicate a weakening of the antiapoptotic protection of liver cells of LIFP animals, which creates conditions for activation of the “mitochondrial branch” of apoptosis. Melatonin treatment of LIFP mice resulted in a 3.3-fold increase in Bcl-2 expression area and a 2.7 % decrease in Bcl-2 region brightness compared with the experimental untreated group. Bad protein parameters were unreliable. Thus, melatonin treatment of animals cancels the effect of LIFP, restoring the Bcl-2 expression area and increasing this protein concentration, which indicates an increase in antiapoptotic protection and creates conditions for blocking the development of the “mitochondrial branch” of apoptosis in liver cells

Ce-doped Li6Ln(BO3)3 (Ln = Y, Gd) Single crystals fibers grown by micro-pulling down method and luminescence properties

Ce3+-doped borate crystal fibers of Li6Gd(BO 3)3 (LGBO) and Li6Y(BO3)3 (LYBO) compositions are grown by the micro-pulling down (μ-PD) method for potential application in developing new neutron detectors. The ternary equilibrium diagram of Li2O-Gd2O3-B 2O3 is drawn and the preparations of homogeneous mixed LGBO and LYBO powders and growth conditions for single crystal fibers are discussed. Absorption, excitation and X-ray luminescence spectra are investigated. Absolute light yield derived from energy spectra and kinetic decay curves measured under α- and γ-scintillations of Ce 3+-doped LGBO and LYBO single crystal fibers is provided. © 2012 Elsevier B.V. All rights reserved

Hysteroscopic metroplasty: current status of the problem

Hysteroscopic metroplasty is very important for the restoration of the normal anatomy of the uterus, creation of the conditions for favorable obstetric outcomes. This review of the current scientific papers on the topic summarizes the data on the indications, preoperative preparation, and techniques of hysteroscopic metroplasty. It also presents the information on the approaches to the evaluation of the effectiveness of this kind of surgery, peculiarities of the postoperative care, preventive treatment of the intra- and postoperative complications. The paper provides state-of-the art information on the importance of the hysteroscopic metroplasty for the reproductive health of a woman and peculiarities of the gestation course after the dissection of the intrauterine septum.Гистероскопическая метропластика имеет важное значение для восстановления нормальной анатомии матки, создания условий для благоприятных акушерских исходов. В обзоре данных современной литературы обобщены сведения о показаниях, предоперационной подготовке, методах гистероскопической метропластики. Приведена информация о способах оценки эффективности данной операции, особенностях ведения послеоперационного периода, профилактики интра- и послеоперационных осложнений, а также представлены современные сведения о значении гистероскопической метропластики для репродуктивного здоровья женщины, особенностях течения беременности после рассечения внутриматочной перегородки