TRANSMÍDIA E REDES SOCIAIS: aspectos da inovação no telejornalismo

A partir de um olhar direcionado ao Jornal da Record News, esta pesquisa procura compreender os usos e apropriações da transmídia e das redes sociais digitais enquanto aspectos de inovação nos modos de fazer telejornalismo. O JR News se autointitula o primeiro telejornal transmídia do Brasil e usa as redes sociais para transmitir suas edições, chamadas e até reuniões de pauta, ao vivo, com a participação do público. Adotando-se entrevista semiestruturada e observação direta como procedimentos metodológicos, este artigo ampara-se em Charron e Bonville (2016), Recuero (2009), Alzamora e Tárcia (2012), Zago e Bastos (2013), Canavilhas (2013), Martins, Castro e Vinagre (2017), dentre outros, para discutir intersecções entre transmidialidade e redes sociais como alternativa para o jornalismo frente às mudanças na contemporaneidade.   PALAVRAS-CHAVE: Jornalismo Transmídia; Redes Sociais; Inovação no jornalismo, JR News.     ABSTRACT Based on a look at the Journal of Record News, this research seeks to understand the uses and appropriations of transmedia and the digital and social networks as aspects of innovation in ways of doing telejournalism. The JR News calls itself the first transmedia telejournal in Brazil and uses social networks to broadcast its issues, calls and even staff meetings, live, with audience participation. This article is based on Charron and Bonville (2016), Recuero (2009), Alzamora and Tárcia (2012), Zago and Bastos (2013), Canavilhas (2013), Martins, Castro and Vinagre (2017), among others, to discuss intersections between transmidiality and social networks as an alternative to journalism in the face of changes in contemporaneity.   KEYWORDS: Transmedia Journalism; Social networks; Innovation in journalism; JR News.     RESUMEN A partir de una mirada dirigida al Jornal da Record News, esta investigación busca comprender los usos y apropiaciones de la transmedia y de las redes sociales digitales como aspectos de innovación en los modos de hacer teleperiodismo. El JR News se autointitula el primer telediario transmedia de Brasil y utiliza las redes sociales para transmitir sus ediciones, llamadas e incluso reuniones de pauta, en vivo, con la participación del público. Adoptando entrevista semiestructurada y observación directa como procedimientos metodológicos, este artículo se ampara en Charron y Bonville (2016), Recuero (2009), Alzamora y Tárcia (2012), Zago y Bastos (2013), Canavillas (2013), Martins, Castro y Vinagre (2017), entre otros,  para discutir intersecciones entre transmidialidad y redes sociales como alternativa para el periodismo frente a los cambios en la contemporaneidad.   PALABRAS CLAVE: Periodismo transmedia; Redes sociales; Innovación en el periodismo, JR News

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer