Simplified SIMPs and the LHC

The existence of Dark Matter (DM) in the form of Strongly Interacting Massive Particles (SIMPs) may be motivated by astrophysical observations that challenge the classical Cold DM scenario. Other observations greatly constrain, but do not completely exclude, the SIMP alternative. The signature of SIMPs at the LHC may consist of neutral, hadron-like, trackless jets produced in pairs. We show that the absence of charged content can provide a very efficient tool to suppress dijet backgrounds at the LHC, thus enhancing the sensitivity to a potential SIMP signal. We illustrate this using a simplified SIMP model and present a detailed feasibility study based on simulations, including a dedicated detector response parametrization. We evaluate the expected sensitivity to various signal scenarios and tentatively consider the exclusion limits on the SIMP elastic cross section with nucleons.Comment: 18 pages, 7 figure

SPATIAL ANALYSIS OF SOIL FERTILITY MANAGEMENT USING INTEGRATED HOUSEHOLD AND GIS DATA FROM SMALLHOLDER KENYAN FARMS

Although soil fertility is recognized as a primary constraint to agricultural production in developing countries, use of fertilizer in Sub-Saharan Africa is declining. Smallholder farmers still rely heavily on livestock manure for soil fertility management. To explore the determinants of soil fertility management practices, including both the use of cattle manure and inorganic fertilizer, data are used from a sample of 3,330 geo-referenced farm households across Central and Western Kenya. A bivariate probit model is applied to jointly examine the use of the two technologies. Particular attention is given to measures of location related to market access and agroclimate, which in the adoption literature have typically been addressed using crude proxies. To avoid such proxies, GIS-derived variables are integrated into the household decision model. Their use also allows the spatial prediction of uptake based on parameter estimates. The results show clearly the derived-demand nature of soil fertility services, based on markets for farm outputs. They also illustrate that supply of manure for soil fertility amendments is conditioned by demand for livestock products, especially milk. The integration of GIS-derived variables is shown to better estimate the effects of location than the usual measures employed, and offers scope to wider use in technology adoption research.spatial analysis, soil fertility, market access, technology adoption., Farm Management, Land Economics/Use, Q12, Q16,

Ecological Consequences of Shoreline Hardening: A Meta-Analysis

Protecting coastal communities has become increasingly important as their populations grow, resulting in increased demand for engineered shore protection and hardening of over 50% of many urban shorelines. Shoreline hardening is recognized to reduce ecosystem services that coastal populations rely on, but the amount of hardened coastline continues to grow in many ecologically important coastal regions. Therefore, to inform future management decisions, we conducted a meta-analysis of studies comparing the ecosystem services of biodiversity (richness or diversity) and habitat provisioning (organism abundance) along shorelines with versus without engineered-shore structures. Seawalls supported 23% lower biodiversity and 45% fewer organisms than natural shorelines. In contrast, biodiversity and abundance supported by riprap or breakwater shorelines were not different from natural shorelines; however, effect sizes were highly heterogeneous across organism groups and studies. As coastal development increases, the type and location of shoreline hardening could greatly affect the habitat value and functioning of nearshore ecosystems

Advanced Television Research Program

Contains reports on ten research projects.National Science Foundation Grant MIP 87-14969National Science Foundation FellowshipAdvanced Television Research ProgramAT&T Bell Laboratories Doctoral Support ProgramKodak FellowshipU.S. Air Force - Electronic Systems Division Contract F1 9628-89-K-004

Digital Signal Processing

Contains an introduction and reports on fifteen research projects.National Science Foundation FellowshipU.S. Navy - Office of Naval Research (Contract N00014-81-K-0742)National Science Foundation (Grant ECS 84-07285)Sanders Associates, Inc.U.S. Air Force - Office of Scientific Research (Contract F19628-85-K-0028)AT&T Bell Laboratories Doctoral Support ProgramCanada, Bell Northern Research ScholarshipCanada, Fonds pour la Formation de Chercheurs et /'Aide a la Recherche Postgraduate FellowshipCanada, Natural Science and Engineering Research Council Postgraduate FellowshipAmoco Foundation FellowshipFannie and John Hertz Foundation Fellowshi

The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic, and molecular levels. Female predominance, a survival prognosis similar to other MDS, a low monocyte count, and dysmegakaryopoiesis were the specific clinical and cytological features of del(11q) MDS. In most cases, del(11q) was isolated, primary and interstitial encompassing the 11q22-23 region containing ATM, KMT2A, and CBL genes. The common deleted region at 11q23.2 is centered on an intergenic region between CADM1 (also known as Tumor Suppressor in Lung Cancer 1) and NXPE2. CADM1 was expressed in all myeloid cells analyzed in contrast to NXPE2. At the functional level, the deletion of Cadm1 in murine Lineage-Sca1+Kit+ cells modifies the lymphoid-to-myeloid ratio in bone marrow, although not altering their multilineage hematopoietic reconstitution potential after syngenic transplantation. Together with the frequent simultaneous deletions of KMT2A, ATM, and CBL and mutations of ASXL1, SF3B1, and CBL, we show that CADM1 may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies