Evaluación formativa y desempeño docente, en los maestros de comunicación de la Unidad de Gestión Educativa Local N°13 – Yauyos, 2020

La presente investigación titulada: Evaluación Formativa y Desempeño Docente, en los maestros de Comunicación de la Unidad de Gestión Educativa Local N°13 – Yauyos, 2020. Tiene el objetivo de determinar la relación entre Evaluación Formativa y Desempeño Docente aplicado por los maestros del área de comunicación en la UGEL Nº13 Yauyos 2020. La investigación desarrollada ha sido clasificada como cuantitativa, no-experimental, aplicativa, descriptiva, transversal y correlacional: ya que no se generan cambios entre las unidades de análisis, los datos se recopilan en un solo momento y se propone determinar el grado de relación entre las variables analizadas y que son aplicadas por los docentes del área de comunicación de la UGEL Nº13 que está ubicada en la provincia de Yauyos, la unidad de análisis fue cada docente que labora en el área de comunicación de la UGEL 13. Como resultado de la investigación se ha encontrado que se concluye que existe relación directa y significativa (Rho de Spearman= 0.564 y Sig. = 0,000), entre la variable Evaluación Formativa aplicada por los docentes y el Desempeño Docente que aplican en el área de comunicación de la UGEL Nº13 Yauyos 2020

Factores asociados a la intención de uso de la vasectomía en trabajadores de la empresa Segurity Apóstol Santiago SAC Lima, mayo 2023

El objetivo de la investigación fue determinar los factores asociados a la intención de uso de la vasectomía en trabajadores de la empresa Segurity Apóstol Santiago SAC Lima, mayo 2023. El diseño de investigación fue no experimental, trasversal analítico, correlacional. El tamaño muestral estuvo conformado por el total del personal activo varón de trabajadores de la empresa Segurity Apóstol Santiago SAC en Lima que laboraron en el mes de mayo del año 2023. Se utilizó un cuestionario virtual donde se midieron factores tales como sociodemográficos, culturales, reproductivos, apoyo conyugal y nivel de conocimiento la vasectomía y su asociación con la intención de uso de la vasectomía. Los resultados de la investigación demostraron que el único factor sociodemográfico asociado a la intención de uso de la vasectomía fue la religión (p=0.01). El factor nivel de conocimiento, los factores reproductivos, culturales y apoyo conyugal no tuvieron asociación significativa con la intención de uso de la vasectomía. Se concluye que la religión fue el factor asociado a la intención de uso de la vasectomía en los trabajadores de la empresa Segurity Apóstol Santiago SAC Lima, mayo 2023

Cancer Stem Cells as a Result of a Reprogramming-Like Mechanism

Open Access: under CC BY-NCSA 3.0 license.Research in our groups is partially supported by FEDER and by MICINN (SAF2009-08803 to ISG), by Junta de Castilla y León (Proyecto Biomedicina 2009-2010 to ISG, and Proyecto Biomedicina 2010-2011 to CVD), by MEC OncoBIO Consolider-Ingenio 2010 (Ref. CSD2007- 0017) to ISG, by NIH grant (R01 CA109335-04A1) to ISG, by Sandra Ibarra Foundation to ISG, and by Group of Excellence Grant (GR15) from Junta de Castilla y Leon to ISG and JJC.Peer reviewe

Reactivación económica postpandemia y su incidencia en la rentabilidad de la empresa comercial DULCEMAR S.A.C, Chimbote – periodo 2021

El presente informe de investigación titulado “Reactivación Económica y su incidencia en la rentabilidad de la empresa comercial DULCEMAR S.A.C. – 2021, tuvo como propósito determinar la incidencia de la reactivación económica en la rentabilidad de la empresa comercial DULCEMAR S.A.C. durante el periodo 2021. La investigación siguió una metodología cuantitativa, de diseño descriptivo – propositivo, no experimental de corte transversal. Se utilizó una muestra no probabilística, por lo que se estimó a 04 trabajadores. Como instrumentos de recolección de datos se hizo uso de una guía de entrevista validada por expertos y sometida a criterios de confiabilidad. Los resultados fueron obtenidos haciendo uso del análisis descriptivo. Como conclusión la investigación da cuenta que la reactivación económica si incide en la rentabilidad, donde se pudo apreciar que la empresa comercial DULCEMAR S.A.C., gracias a la reactivación económica incrementó su rentabilidad económica y financiera en el periodo 2021

The Role of Sphingolipids Metabolism in Cancer Drug Resistance

Acid ceramidase (AC); Glucosylceramide synthase (GCS); ShingolipidsCeramidasa ácida (AC); Glucosilceramida sintasa (GCS); EsfingolípidosCeramidasa àcida (AC); Glucosilceramida sintasa (GCS); EsfingolípidsDrug resistance continues to be one of the major challenges to cure cancer. As research in this field evolves, it has been proposed that numerous bioactive molecules might be involved in the resistance of cancer cells to certain chemotherapeutics. One well-known group of lipids that play a major role in drug resistance are the sphingolipids. Sphingolipids are essential components of the lipid raft domains of the plasma membrane and this structural function is important for apoptosis and/or cell proliferation. Dysregulation of sphingolipids, including ceramide, sphingomyelin or sphingosine 1-phosphate, has been linked to drug resistance in different types of cancer, including breast, melanoma or colon cancer. Sphingolipid metabolism is complex, involving several lipid catabolism with the participation of key enzymes such as glucosylceramide synthase (GCS) and sphingosine kinase 1 (SPHK1). With an overview of the latest available data on this topic and its implications in cancer therapy, this review focuses on the main enzymes implicated in sphingolipids metabolism and their intermediate metabolites involved in cancer drug resistance.We thank Teresa Moline and Rosa Somoza from the VHIR. This work was supported by grants from the Instituto de Salud Carlos III (ISCIII; PI20/00556 and CP03/00101 [ML]) and CIBERONC (ML). This work was also co-financed by the European Regional Fund (ERDF) and AECC (Spanish Association of Cancer Research) (Founding Ref. GC16173720CARR [ML]). YG-M, CM, and AS-G were supported by the VHIR, iP-FIS (ISCIII) and VHIR fellowships, respectively

Effect of Continuous Positive Airway Pressure on Inflammatory, Antioxidant, and Depression Biomarkers in Women With Obstructive Sleep Apnea: A Randomized Controlled Trial

Study objectives: The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA. Methods: We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ? 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor ? (TNF?), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest. Results: Women had a median (25th-75th percentiles) age of 58 (51-65) years, body mass index 33.5 (29.0-38.3) kg/m2, and AHI 33.3 (22.8-49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNF? levels decreased compared to the control group (-0.29 ± 1.1 vs -0.06 ± 0.53, intergroup difference -0.23 [95% CI = -0.03 to -0.50]; p = 0.043). Conclusions: Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA

MUNICIPAL ENVIRONMENTAL MANAGEMENT: A PROPOSAL OF INSTRUMENTS FOR DIAGNOSIS OF PUBLIC ENVIRONMENTAL POLICIES IN THE METROPOLITAN AREA OF SALVADOR (MAS)

The aim in this paper is to propose a model for mapping strategies of municipal environmental management for local environmental public policies. To do so, the study adopted a theoretical approach. More specifically, there is discussion on the concepts of public policies and the scenario of the Brazilian municipal environmental management, a brief history of the aspects that involve current national environmental policies. Methodologically, a bibliographical study was carried out through a literature review, which enabled the proposal of instruments for mapping actions and strategies of environmental management in the municipalities of the Metropolitan Area of Salvador (MAS). This theoretical study resulted in the creation of a model form that will be used by empirical researches for mapping the environmental public policies in the MAS City Halls

Senegalese sole transcriptomic profiles in response to different betanodavirus RGNNV/SJNNV reassortant strains

Betanodaviruses are the causative agents of viral nervous necrosis (VNN), a disease that has been reported in more than 40 marine and freshwater fish species worldwide, including Senegalese sole (Solea senegalensis). Based on the variable region T4 (RNA2), betanodaviruses have been classified into 4 genotypes: striped jack nervous necrosis virus (SJNNV), tiger puffer nervous necrosis virus (TPNNV), redspotted grouper nervous necrosis virus (RGNNV), and barfin flounder nervous necrosis virus (BFNNV). Reassortant isolates combining genomic segments from the SJNNV and RGNNV genotypes have been obtained from farmed fish species. The reassortant SpSs-IAusc160.03 (wild type reassortant), with a genome consisting of RGNNV-type RNA1 and SJNNV-type RNA2 segments, is more suited for infecting sole than the parental genotypes, causing 100% mortality by bath challenges. Furthermore, compared with the parental SJNNV genotype, this reassortant strain presents two aminoacidic substitutions (positions 247 and 270) at the extreme C-terminal of the capsid protein, which are involved in host specificity. In the current study, the RNA-Seq technology has been used to determine changes in Senegalese sole transcriptome after infection with the wild type and a less virulent recombinant (rSs160.03247+270) with mutations at aminoacids 247 (serine to alanine) and 270 (serine to asparagine), provoking a 40% decreased mortality. Animals (5 g weight) were distributed into two groups to be intramuscularly injected with the above described viral strains (2x105 TCID50/fish). A negative control group (L15-injected) was also established. Head kidney and nervous tissues (eye+brain) were sampled at 48 post-inoculation. A total of 633 genes were differentially expressed (DEGs) in animals infected with the wild type isolate (358 up-regulated and 49 down-regulated in head kidney; 206 up-regulated and 20 down-regulated in eye+brain), whereas only 393 genes were differentially expressed in animals infected with the mutated isolate (129 up-regulated and 10 down-regulated in head-kidney; 28 up-regulated and 226 down-regulated in eye+brain). The results obtained indicate a 37.9% decrease in the number of DEGs after infection with the mutated reassortant, as well as an inversion in the proportion of genes up/down-regulated in nervous tissue of these animals. In addition, the expression patterns of genes coding for proteins involved in the IFN type I pathway were different in both group of animals. Thus, genes coding for proteins acting as mediators of IFN type I expression (MDA5, LGP2, IRF3, IRF7) and IFN-stimulated genes (ISG15, Mx, PKR, IFI6, IFI35, IFI44, IFIT-1, among others) were up-regulated in animals infected with the wild type reassortant, whereas no-differential expression of these genes was observed in animals infected with the mutated isolate. The different transcriptomic profiles obtained could help to better understand NNV pathogenesis in Senegalese sole, setting up the importance as virulence determinants of aminoacids at positions 247 and 270 within the RNA2 segment. Furthermore, the results obtained permit to identify DEGs that could be used to develop new strategies to control this infectious disease, which has reached high relevance in the aquaculture sector.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS

Objective: Several factors influence the clinical course of autoimmune inflammatory diseases such as MS and inflammatory bowel disease. Only recently, the complex interaction between the gut microbiome, dietary factors, and metabolism has started to be appreciated with regard to its potential to modulate acute and chronic inflammation. One of the molecular sensors that mediates the effects of these environmental signals on the immune response is the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor with key functions in immune cells. Methods: In this study, we analyzed the levels of AHR agonists in serum samples from patients with MS and healthy controls in a case-control study. Results: We detected a global decrease of circulating AHR agonists in relapsing-remitting MS patients as compared to controls. However, during acute CNS inflammation in clinically isolated syndrome or active MS, we measured increased AHR agonistic activity. Moreover, AHR ligand levels in patients with benign MS with relatively mild clinical impairment despite longstanding disease were unaltered as compared to healthy controls. Conclusions: Collectively, these data suggest that AHR agonists in serum are dynamically modulated during the course of MS. These findings may guide the development of biomarkers to monitor disease activity as well as the design of novel therapeutic interventions for MSInstituto de Salud Carlos III, Unión Europea PT13/0010/004

Tunable narrowband Excitonic Optical Tamm States enabled by a metal-free all-organic structure

Optical Tamm States (OTS) are confined optical modes that can occur at the interface between two highly reflective structures. However, due to the strong reflectance required, their implemen-tation with highly processable and metal-free flexible materials has proven challenging. Herein, we develop the first structure supporting OTS based only on organic polymeric materials, demon-strating a photonic platform based on non-critical, widely available, and easily processable mate-rials. The structures fabricated present large areas and consist of a narrowband multi-layered polymeric Distributed Bragg Reflector (DBR) followed by a thin film of J-aggregate molecular exci-tonic material that can act as a highly reflective surface within a narrowband range. We take ad-vantage of the narrowband spectral response of the DBR and of the reflective molecular layer to tune the OTS band by varying the periodicity of the multilayer, opening the door for the fabrica-tion of OTS structures based on lightweight integrable excitonic devices with cost-effective proce-dures.Comment: 15 pages, 8 (3+5) figures, supplementary information include