Ursinus College Bulletin Vol. 11, No. 10, July 1895

A digitized copy of the July 1895 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1107/thumbnail.jp

Ursinus College Bulletin Vol. 11, No. 7, April 1895

A digitized copy of the April 1895 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1104/thumbnail.jp

Ursinus College Bulletin Vol. 11, No. 8, May 1895

A digitized copy of the May 1895 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1105/thumbnail.jp

Ursinus College Bulletin Vol. 11, No. 6, March 1895

A digitized copy of the March 1895 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1103/thumbnail.jp

Ursinus College Bulletin Vol. 11, No. 9, June 1895

A digitized copy of the June 1895 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1106/thumbnail.jp

Ursinus College Bulletin Vol. 11, No. 5, February 1895

A digitized copy of the February 1895 Ursinus College Bulletin.https://digitalcommons.ursinus.edu/ucbulletin/1102/thumbnail.jp

Symptom Management in Metastatic Breast Cancer

Approximately 40,000 women die as a result of breast cancer each year and many more live with advanced disease. When breast cancer recurs, the goals of treatment often shift from one of cure to controlling the disease for as long as possible while palliating symptoms interfering with the patient's functional status and quality of life. This requires ongoing discussions with the patient and family about the goals of care. Many symptoms depend on the site of metastasis, with bone being the most frequent, and commonly occur with fatigue, depression, insomnia, and pain. The purpose of this paper is to identify and provide an overview of the management of the most common symptoms in patients with breast cancer metastases

Ursinus College Alumni Journal, Spring 1946

Farewells to Ursinus • Education for veterans • Alumni Day • President\u27s page • Faculty and staff changes announced • Exhibits to be shown Commencement week • College pastor retires after 18 years\u27 service • Loyalty Fund grows • Professor and Mrs. Sheeder to leave Ursinus • Enrollments remain at high peak • Warren K. Hess \u2731, elected Berks judge • Wounded veterans attend courses • Ursinus and World War II • Store displays mural of college • News from the campus • Athletic policy defined • Sports revue • Secretary\u27s letter • Ensminger \u2714, receives Legion of Merit medal • Former professor invents electronic computer • Control of nuclear energy • News about ourselves • Necrology • Dr. DeWire aided in atom bomb experiments • Alumni Association nomineeshttps://digitalcommons.ursinus.edu/alumnijournal/1027/thumbnail.jp

\u3cem\u3eCPT1A\u3c/em\u3e Methylation Is Associated with Plasma Adiponectin

Background and Aims—Adiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health. Despite clinical relevance and high heritability, the determinants of plasma adiponectin levels remain poorly understood. Methods and Results—We conducted the first epigenome-wide cross-sectional study of adiponectin levels using methylation data on 368,051 cytosine-phosphate-guanine (CpG) sites in CD4+ T-cells from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n= 991). We fit linear mixed models, adjusting for age, sex, study site, T-cell purity, and family. We have identified a positive association (regression coefficient ± SE= 0.01 ± 0.001, P=3.4x10−13) between plasma adiponectin levels and methylation of a CpG site in CPT1A, a key player in fatty acid metabolism. The association was replicated (n=474, P=0.0009) in whole blood samples from the Amish participants of the Heredity and Phenotype Intervention (HAPI) Heart Study as well as White (n=592, P=0.0005) but not Black (n=243, P=0.18) participants of the Bogalusa Heart Study (BHS). The association remained significant upon adjusting for BMI and smoking in GOLDN and HAPI but not BHS. We also identified associations between methylation loci in RNF145 and UFM1 and plasma adiponectin in GOLDN and White BHS participants, although the association was not robust to adjustment for BMI or smoking. Conclusion—We have identified and replicated associations between several biologically plausible loci and plasma adiponectin. These findings support the importance of epigenetic processes in metabolic traits, laying the groundwork for future translational applications