Национально-обусловленный дискурсивный паттерн русскоязычных текстов

The article deals with the currently important issue of the influence of mentality and national character on peculiarities of a nation’s mindset, and as a result on the peculiarities of text-building procedure. The author calls such peculiarities of text-building procedure “nationally determined discourse pattern” and gives its definition. In order to identify the peculiarities of the nationally determined discourse pattern typical for Russian-speaking people the author conducted the comparative analysis of Russian-speaking students’ papers, written both in Russian and in English. The process of identifying the features of the discourse pattern was based on a number of typologies of nationally determined mindsets and some national features of Russian people, which were described by several researchers in the spheres of culturology and ethno-psychology. The features of Russian people’s discourse pattern described in the article appear to be very important in teaching foreign languages, since teachers of English have to take these features into consideration while teaching Effective Writing in English to Russian-speaking students.Данная статья посвящена актуальному вопросу влияния менталитета и национального характера на особенности мышления народа и, как следствие, на особенности текстопостроения. Данные особенности текстопостроения автор статьи именует национально-обусловленным дискурсивным паттерном и дает ему определение. Для определения особенностей национально-обусловленного дискурсивного паттерна носителей русского языка был проведен сравнительный анализ письменных работ русскоязычных учащихся, написанных ими как на русском, так и на английском языках. Выделение особенностей дискурсивного паттерна велось на основе ряда типологий национально-обусловленных видов мышления, а также некоторых национальных чертах носителей русского языка, выявленных различными исследователями в области культурологии и этнопсихологии. Описанные в статье характеристики национально-обусловленного дискурсивного паттерна носителей русского языка имеют большое значение для лингводидактики, так как преподаватели английского языка должны учитывать данные характеристики при обучении русскоязычных учащихся письменной речи на английском языке

Equine Tendinopathy Therapy Using Mesenchymal Stem Cells

The application of animal mesenchymal stem cells has been actively studied in veterinary medicine over the past decade. In horses, the use of stem cells is mainly aimed at the treatment and maintenance of the musculoskeletal system. This review summarizes the currently published data on the therapeutic use of mesenchymal stem cells in equine tendon injuries. Tendon lesions are the most common cause of horse limp. It has been demonstrated that the use of mesenchymal stem cells compared with traditional methods of treatment can significantly reduce the re-injury. Currently, there are a large number of stem cell application protocol versions. Many researchers have obtained positive clinical results in using a combination of mesenchymal stem cells and platelet-rich blood plasma. Studies have demonstrated the safety of using allogeneic mesenchymal stem cells as an alternative to autologous. This review shows that the application of mesenchymal stem cells for horse tendon regeneration is a perspective area in veterinary medicine

Diffusion coefficient when fine aerosol media propagate in a confined volume

An experimental estimation is reported of the value of the effective diffusion coefficient during aerosol deposition in a confined volume. Aerosol propagation regularities have experimentally been studied in a chamber of a complex configuration with different placement of aerosol generators

Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome

Background: Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabilities remain largely elusive in HPV-negative head and neck squamous cell carcinoma (HNSCC). Methods: The cytotoxic and radiochemosensitizing potential of targeting 10 RTK and β1 integrin was determined in up to 20 3D matrix-grown HNSCC cell models followed by drug screening and patient-derived organoid validation. RNA sequencing and protein-based biochemical assays were performed for molecular characterization. Bioinformatically identified transcriptomic signatures were applied to patient cohorts. Results: Fibroblast growth factor receptor (FGFR 1–4) targeting exhibited the strongest cytotoxic and radiosensitizing effects as monotherapy and combined with β1 integrin inhibition, exceeding the efficacy of the other RTK studied. Pharmacological pan-FGFR inhibition elicited responses ranging from cytotoxicity/radiochemosensitization to resistance/radiation protection. RNA sequence analysis revealed a mesenchymal-to-epithelial transition (MET) in sensitive cell models, whereas resistant cell models exhibited a partial epithelial-to-mesenchymal transition (EMT). Accordingly, inhibition of EMT-associated kinases such as EGFR caused reduced adaptive resistance and enhanced (radio)sensitization to FGFR inhibition cell model- and organoid-dependently. Transferring the EMT-associated transcriptomic profiles to HNSCC patient cohorts not only demonstrated their prognostic value but also provided a conclusive validation of the presence of EGFR-related vulnerabilities that can be strategically exploited for therapeutic interventions. Conclusions: This study demonstrates that pan-FGFR inhibition elicits a beneficial radiochemosensitizing and a detrimental radioprotective potential in HNSCC cell models. Adaptive EMT-associated resistance appears to be of clinical importance, and we provide effective molecular approaches to exploit this therapeutically

Experimental study into the evolution of pulse atomization-generated aerosol systems in confined space

Basic characteristics of the powder aerosol generated by the shockwave method using a pyrotechnic atomizer were experimentally studied

Experimental study into the evolution of pulse atomization-generated aerosol systems in confined space

Basic characteristics of the powder aerosol generated by the shockwave method using a pyrotechnic atomizer were experimentally studied

Measurement Procedure for Surface Emissivity of Heat-Shielding Materials

A procedure is suggested for the measurement of the integral emissivity coefficient of heat-shielding materials in the temperature range close to the thermal destruction temperature

Measurement Procedure for Surface Emissivity of Heat-Shielding Materials

A procedure is suggested for the measurement of the integral emissivity coefficient of heat-shielding materials in the temperature range close to the thermal destruction temperature

Measurement Procedure for Surface Emissivity of Heat-Shielding Materials

A procedure is suggested for the measurement of the integral emissivity coefficient of heat-shielding materials in the temperature range close to the thermal destruction temperature

Deictic Elements as Means of Text Cohesion and Coherence in Academic Discourse

The article presents the results of the research aimed at analyzing some functions and features of deictic elements in academic discourse in English. The material under analysis covers 20 academic texts written by English-speaking linguists. In the article it is proved that in academic discourse deictic elements can operate only within the fixed scheme of deictic coordinates, which has got three main elements: deictic center, deictic element, and antecedent/subsequent element. Out of this scheme deictic elements fail to fulfill referential procedure. All deictic elements in academic discourse are divided into two big groups: conventional deictic elements and endemic ones. The result of the research shows that conventional deictic elements in most cases provide text cohesion (within small text units, such as adjoining sentences); whereas endemic deictic elements tend to serve for text coherence (in larger text units, such as paragraphs, chapters, etc.). Thus, deictic elements can be considered important units providing text-building