An Experimental Study of Student Personnel Guidance with Freshman Girls at Omaha Central High School

During the twentieth century, because of the increase in the number of students in colleges, universities, and secondary schools, the shift in the responsibility for students from the home to the school, and the present-day emphasis upon personnel work, there has come a steady increase in the number of deans for women students and the importance of their function in the public eye. New deanships have been established in many colleges, universities, and secondary schools; since 1919 twenty-four courses have been organized in different institutions for the purpose of training deans; and the membership of the National Association of Deans of Women has increased from 18 in 1903 to 1,015 in 1927

NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods

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Integrated Text Mining and Chemoinformatics Analysis Associates Diet to Health Benefit at Molecular Level.

Awareness that disease susceptibility is not only dependent on genetic make up, but can be affected by lifestyle decisions, has brought more attention to the role of diet. However, food is often treated as a black box, or the focus is limited to few, well-studied compounds, such as polyphenols, lipids and nutrients. In this work, we applied text mining and Naïve Bayes classification to assemble the knowledge space of food-phytochemical and food-disease associations, where we distinguish between disease prevention/amelioration and disease progression. We subsequently searched for frequently occurring phytochemical-disease pairs and we identified 20,654 phytochemicals from 16,102 plants associated to 1,592 human disease phenotypes. We selected colon cancer as a case study and analyzed our results in three directions; i) one stop legacy knowledge-shop for the effect of food on disease, ii) discovery of novel bioactive compounds with drug-like properties, and iii) discovery of novel health benefits from foods. This works represents a systematized approach to the association of food with health effect, and provides the phytochemical layer of information for nutritional systems biology research

Postoperative Pain Treatment in Day Surgery: A Quality Improvement Study Examining the Needs of Opioid and Effects of Oxycodone and Morphine

Background: There is sparse literature providing evidence for postoperative pain treatment in day surgery and for differences between morphine and oxycodone. Objectives: The objectives of this study were to examine the need for opioids and the effects of morphine versus oxycodone for pain relief and side effects at home after day surgery. Methods: This study was a prospective observational study with a quasi-randomized approach. Data consisted of self-reported three-day registration of use and the effects of the opioids, their side effects, and patient satisfaction with regards to pain treatment in a Danish day surgery conducting orthopedic and abdominal surgery. The outcomes, including the use of opioids, self-reported pain relief, and related side effects (nausea, fatigue, dizziness, and skin itchiness) were measured by a numeric rating scale and patient satisfaction with regards to pain treatment. Results: Out of the 199 included day surgery patients, 162 (81%) returned self-reported postoperative data. A total of 73% of the patients had used opioids an average of 4 times (range 1 - 16). Median levels of nausea, dizziness, and skin itching were 0 (IQR 0 - 3) whereas the median level of fatigue was 3 (IQR 0 - 6). More than 90% of the patients were satisfied or very satisfied with their postoperative pain treatment. No statistically significant differences were found between oxycodone and morphine in regard to onset time, level, duration of pain treatment, and the experienced side effects. Conclusions: Three-quarters of the patients used opioids after day surgery with a substantially varied number of doses. Few patients experienced substantial side effects, and the patients were generally satisfied with their pain treatment. No significant difference was found between oxycodone and morphine. The need for opioids after day surgery varies substantially and further investigations on individuals and follow-up are needed

Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks

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N-terminal and core-domain random mutations in human topoisomerase II α conferring bisdioxopiperazine resistance

AbstractRandom mutagenesis of human topoisomerase II α cDNA followed by functional expression in yeast cells lacking endogenous topoisomerase II activity in the presence of ICRF-187, identified five functional mutations conferring cellular bisdioxopiperazine resistance. The mutations L169F, G551S, P592L, D645N, and T996L confer >37, 37, 18, 14, and 19 fold resistance towards ICRF-187 in a 24 h clonogenic assay, respectively. Purified recombinant L169F protein is highly resistant towards catalytic inhibition by ICRF-187 in vitro while G551S, D645N, and T996L proteins are not. This demonstrates that cellular bisdioxopiperazine resistance can result from at least two classes of mutations in topoisomerase II; one class renders the protein non-responsive to bisdioxopiperazine compounds, while an other class does not appear to affect the catalytic sensitivity towards these drugs. In addition, our results indicate that different protein domains are involved in mediating the effect of bisdioxopiperazine compounds

Theorizing the Transcendent Persona: Amelia Earhart’s Vision in The Fun of It

In this article, we define and theorize the ‘‘transcendent persona,’’ a discursive strategy in which a rhetor draws from a boundary-breaking accomplishment and utilizes the symbolic capital of that feat to persuasively delineate unconventional ways of communicating and behaving in society. Aviator Amelia Earhart’s autobiography The Fun of It (1932) functions as an instructive representative anecdote of this concept and demonstrates that the transcendent persona’s persuasive force hinges on one’s ability to balance distance from audiences with similarities to them. Striking such a balance creates a platform for rhetors to promote transformative visions of society. Earhart utilized the transcendent persona to illustrate an alternative vocabulary of what contemporary theorists might call feminine gender performativity. The article concludes by exploring the implications of the transcendent persona as an enduring, rhetorical resource for communicators, as well as for scholars of persuasion and social change, religious communication, and communication history