Stevens-Johnsonov sindrom : prikaz slučaja neuobičajene alergije na autobus

Stevens-Johnson syndrome is an uncommon inflammatory skin disorder in which immune mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. Herein, an unusual case with strange complaint of “bus allergy” is presented, suffering from severe generalized itching and skin lesions, followed by ulcers in his mouth and genitalia. The diagnosis of Stevens-Johnson syndrome was made and appropriate treatment was advised. However, detailed medical history revealed a completely different cause of his allergic reactions, as he had occasionally used dimenhydrinate because of motion sickness in his history. Therefore, adverse drug reaction to dimenhydrinate was considered as the main underlying cause of the disease. In conclusion, thorough medical history should be taken to make a definitive diagnosis and identify the underlying disease, since accurate diagnosis and appropriate treatment can prevent further complications.Stevens-Johnsonov sindrom je rijetka upalna bolest kože gdje se pretpostavlja da su uključeni imuni mehanizmi, citotoksične reakcije i odgođena preosjetljivost. Ovdje se prikazuje neuobičajen slučaj čudne “alergije na autobus” u bolesnika s teškim generaliziranim svrbežom i oštećenjima kože, nakon čega su nastali ulkusi u njegovim ustima i genitalijama. Kod bolesnika je dijagnosticiran Stevens-Johnsonov sindrom i preporučeno je odgovarajuće liječenje. Međutim, podrobna anamneza otkrila je potpuno drugi uzrok njegovih alergijskih reakcija, jer je povremeno uzimao dimenhidrat zbog bolesti pokreta u anamnezi. Stoga je zaključeno da je štetna reakcija na dimenhidrat bila glavni osnovni uzrok bolesti. Postavljanje konačne dijagnoze i utvrđivanje osnovne bolesti zahtijeva podrobno uzimanje anamneze, jer točna dijagnoza i primjereno liječenje mogu spriječiti daljnje komplikacije

The Prevalence of Allergy symptoms in Students in Rural Area

Background: Asthma, allergic rhinitis and eczema as a common disorder in childhood, has many epidemiologic variations in different geographic areas. This study aimed at determining the prevalence of pediatric allergic disease in rural area of Babol. Methods: This analytical-cross sectional study was performed in 2012 by random sampling on 2 groups of children; the first group aged 6-7 years (n=1735) and the second group aged 12-14 years (n=2080) during 2012. Data was collected by ISAAC first phase questionnaire and analyzed by SPSS 17 and Chi square test. Results: The prevalence of asthma in elementary school was 19% and in guidance school was 29.9% (p=0.000). The prevalence of allergic rhinitis in primary school in guidance school was 9.9% and 18.1%, respectively (p=0.000). There was no significant difference (p=0.223) between Elementary school (6.1%) and Guidance school (5.5%) in terms of prevalence of eczema. Conclusions: The results showed that the prevalence of asthma and allergic rhinitis in the rural area of Babol was remarkable that was high in older age group and needs to more attention in health program for decreasing this prevalence

Asthma awareness among primary school teachers in Zanjan in 2014

Background: Asthma is the most common chronic respiratory disease and a leading cause of school absenteeism. Awareness, attitude, and knowledge of asthma can play an effective role in controlling this disease and its consequences. Accordingly, this study aimed to determine the level of asthma awareness among primary school teachers in Zanjan. Methods: This descriptive cross-sectional study was conducted on 403 teachers of boys- and girls-only primary schools, who were selected using single-stage cluster sampling. Data were collected using a researcher-made questionnaire, in which higher scores indicated higher level of asthma awareness. Findings were analyzed using descriptive and analytical statistics in SPSS. Results: Data analysis showed that 58 (14.4%) and 345 (85.6%) out of 403 participants were male and female, respectively. The means of age and work experience of the participants were 45±5.53 and 22±5.92 years old, respectively. In addition, teachers’ mean score for asthma awareness was at a good level (12±2.2). Teachers’ mean level of asthma awareness had a significant relationship with gender and history of dealing with asthmatic children (p = 0.03, p = 0.04), while it had no significant relationship with age, work experience, and education level. Conclusion: In this study, the mean level of asthma awareness among the primary school teachers was good. Due to the importance of the disease in children and effective role of teachers in helping them, effective measures must be taken to increase teachers’ awareness

Evaluation the helicobacter pylori infection in asthmatic children compared to control group

Background: Asthma is a highly prevalent chronic respiratory disease in children. Moreover, the underlying causes of asthma exacerbation are important because they are effective in controlling and preventing asthma. The aim of this study was to evaluate the helicobacter pylori infection in controlled and uncontrolled asthmatic children compared to healthy children. Methods: This case- control study was done on 120 children aged 6-14 years with moderate to severe asthma. Diagnosis of asthma was performed according to GINA criteria with respect to the history and clinical examination. In addition, 120 healthy children without asthma were considered as the control group. Helicobacter pylori stool antigen test was evaluated for all patients. In addition to the above information, age, sex, duration of asthma and gastrointestinal symptoms were also recorded for each patient. Data were analyzed using SPSS15, Chi-square and Fisher's exact test and T-test. Results: The mean age of children in the asthmatic and healthy children was 8.3±2 and 8.5±2.3, respectively (p=0.479). Totally, 57.5% and 58.3% of children were boys in the control group, and in asthmatic group, respectively. Thirty percent of children in the control group and 8.3% of children with asthma were H. pylori positive (p=0.000). Mean duration of asthma in children with H. pylori positive (3.3±1.55) and H. pylori negative (3.33±1.56) stool antigen showed no significant difference (p=0.944). Conclusions: The results of this study indicated that there was an inverse relation between helicobacter pylori infection and asthma

Comparison of serum magnesium level between asthmatic and healthy children

Background and Objective: Hypomagnesemia can lead to bronchial smooth muscle contraction and is associated with wheezeing, airway hyperactivity and impairment of lung function. The aim of this study was to compare serum magnesium levels between asthmatic and healthy children. Methods: This case-control study was performed from September 2018 to February 2019. Totally, 125 children (78 asthmatic and 47 healthy non-asthmatic children) aged 3-14 years referred to Amirkola Children's Hospital in Iran were entered to the study. Sampling was done using the available method based on inclusion criteria. Serum magnesium levels were measured in all children in the laboratory of Amirkola Children's Hospital. P<0.05 was considered a significant level. Findings: The mean age of children was 81.21±35.45 months, among them, 77 (61.6) and 48 (38.4) were male and female, respectively. The mean serum magnesium level of children was 2.08 and 2.04 mg/dl in the control and asthma groups, respectively and there was no statistically significant difference between the two groups (p=0.49). Conclusion: Based on the findings of this study, there is no significant difference between serum magnesium levels in asthmatic patients and the control group and it is not necessary to routinely measure magnesium levels in these patients

The prevalence of allergic rhinitis in Iranian children: A systematic review and descriptive meta-analysis

Allergic rhinitis is a very common disorder that affects children. To determine the national prevalence of allergic rhinitis symptoms in Iranian children, we conducted a systematic review and meta-analysis. We conducted a literature search by using the Google Scholar from 1992 until 2012. The search terms were included: Allergic rhinitis, ISAAC and Iran. All the selected studies on children were performed by the International Study of Asthma and Allergies in Childhood protocol. By following the criteria, we gathered 436 articles. The required information from each study includes the authors, date, city, number of children in age groups 6-7 and 13-14. The information was recorded on particularly designed sheets. The data were analyzed by STATA 11. In this study, we analyzed 13 studies. 20668 children were in 6-7 years age group and 22920 were in 13-14 years age group. The pooled prevalence of allergic rhinitis in children 6-7 years of age was 11.9% and in children aged 13-14 was 21.2%. The result shows that the prevalence of allergic rhinitis in Iranian children is high. This information can be used to help allergic rhinitis control. Normal 0 false false false EN-US X-NONE FA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal" mso-tstyle-rowband-size:0 mso-tstyle-colband-size:0 mso-style-noshow:yes mso-style-priority:99 mso-style-parent:"" mso-padding-alt:0cm 5.4pt 0cm 5.4pt mso-para-margin-top:0cm mso-para-margin-right:0cm mso-para-margin-bottom:10.0pt mso-para-margin-left:0cm line-height:115% mso-pagination:widow-orphan font-size:11.0pt font-family:"Times New Roman","serif" mso-ascii-font-family:"Times New Roman" mso-ascii-theme-font:minor-latin mso-hansi-font-family:"Times New Roman" mso-hansi-theme-font:minor-latin mso-bidi-font-family:"Times New Roman" mso-bidi-theme-font:minor-bidi mso-fareast-language:EN-US

Immunoglobulin IgG, IgM, IgA, and IgE Levels in Children with Chronic Sinusitis

Background and purpose: Sinusitis is a common disease in children that can lead to acute and chronic problems and sometimes severe complications. There is lack of evidence on underlying causes of chronic sinusitis in children in Iran, so, this study aimed to investigate the prevalence of humoral immune deficiency in patients with chronic sinusitis. Materials and methods: This cross-sectional study was performed in all children aged 3 to 14 years old with allergic reactions of the upper respiratory tract for more than 12 weeks who attended Amirkola Children Hospital. All patients were evaluated for serum immunoglobulin concentrations (IgM, IgE, IgA, and IgG) by immunoturbidimetric technique. Results: Out of 120 children studied, 79 were males and the patients’ mean age was 6.9 ± 2.9 years. Humoral immunity was found in 49% of children with chronic sinusitis. Elevated IgE was seen in 54 (45%) patients and 12 patients were observed with low levels of IgA (10%). Seven patients had both IgE and IgA deficiency and 10% of immunocompromised patients had IgA deficiency. Sinusitis was more prevalent in fall. The highest incidence was in patients aged 5-9 years old. There was a significant relationship between elevated IgE and season (P=0.013). Conclusion: Our study showed that immunoglobulin abnormality is relatively common and expected in children with sinusitis

Isolated thrombocytopenia report of a rare presentation of childhood Systemic Lupus Erythematosus

Background: Systemic lupus erythematosus (SLE) has various presentations in children. Hematologic abnormalities is common in childhood onset of SLE, however, isolated thrombocytopenia is relatively rare. Thus, we present a child with isolated thrombocytopenia as a rare presentation of SLE. Case presentation: A 12-year-old boy with chief complaints of loss of appetite, weight loss, decreased platelet count (8000/µL) and lymph node enlargement was referred to our hospital. Biopsy of lymph node showed reactive lymphadenopathy. Investigations regarding infectious disease was negative. Platelet count remained low after low dose steroidned therapy. Antinuclear antibody (ANA) and anti-double stranded DNA antibody screening tests were positive with titer of 1/62 and 1/54, respectively. Therefore, juvenile SLE was considered as the final diagnosis and raising the dose of prednisolone to 2mg/kg/day was associated with increasing platelet count to 40000/µL and a week later to 96000/µL. Conclusion: The findings of this study indicate that in cases with isolated thrombocytopenia refractory to conventional dose of steroids, SLE should be considered. This study justifies serum ANA and anti DNA assessment in children with thrombocytopeni