A TiO study of the black-hole binary GRO J0422+32 in a very low state

We present 53 simultaneous photometric (I band) and spectroscopic (6900-9500 Angstroms) observations of J0422+32, taken during December 1997. From these we determine that J0422+32 was in its lowest state yet observed, at I=20.44+/-0.08. Using relative spectrophotometry, we show that it is possible to correct very accurately for telluric absorption. Following this, we use the TiO bands at 7055 Angstroms and 7589 Angstroms for a radial velocity study and thereby obtain a semi-amplitude of 378+/-16kms-1, which yields f(M)=1.191+/-0.021M_solar and q=9.0+2.2-2.7, consistent with previous observations. We further demonstrate that this little explored method is very powerful for such systems. We also determine a new orbital ephemeris of HJD=2450274.4156+/-0.0009 + 0.2121600+/-0.0000002E. We see some evidence for an ellipsoidal modulation, from which we determine the orbital inclination of J0422+32 to be less than 45 degrees. We therefore calculate a minimum mass for the primary of 2.22M_solar, consistent with a black hole, but not necessarily the super-massive one proposed by Beekman et al (1997). We obtain an M4-5 spectral type for the secondary star and determine that the secondary contributes 38+/-2% of the flux that we observe from J0422+32 over the range 6950-8400 Angstroms. From this we calculate the distance to the system to be 1.39+/-0.15kpc.Comment: (1) Department of Physics, Keele University, Keele, Staffordshire, ST5 5BG (2) Department of Astrophysics, Nuclear Physics Laboratory, Keble Road, Oxfo rd, OX1 3RH Accepted, to appear in MNRAS 8 pages, 5 figure

Blade root moment sensor failure detection based on multibeam LIDAR for fault-tolerant individual pitch control of wind turbines

Detection of blade root moment sensor failures is an important problem for fault-tolerant individual pitch control, which plays a key role in reduction of uneven blade loads of large wind turbines. A new method for detection of blade root moment sensor failures which is based on variations induced by a vertical wind shear is described in this paper. The detection is associated with monitoring of statistical properties of the difference between amplitudes of the first harmonic of the blade load, which is calculated in two different ways. The first method is based on processing of the load sensor signal, which contains a number of harmonics. The first harmonic is recovered via least squares estimation of the blade load signal with harmonic regressor and strictly diagonally dominant (SDD) information matrix. The second method is a model-based method of estimation of the first harmonic, which relies on the blade load model and upwind speed measurements provided by multibeam Light Detection and Ranging (LIDAR). This is a new application for future LIDAR-enabled wind turbine technologies. Moreover, adaptation of the load model in a uniform wind field is proposed. This adaptation improves accuracy of the load estimation and hence the performance of the blade load sensor failure detection method

A new mass-ratio for the X-ray Binary X2127+119 in M15?

The luminous low-mass X-ray binary X2127+119 in the core of the globular cluster M15 (NGC 7078), which has an orbital period of 17 hours, has long been assumed to contain a donor star evolving off the main sequence, with a mass of 0.8 solar masses (the main-sequence turn-off mass for M15). We present orbital-phase-resolved spectroscopy of X2127+119 in the H-alpha and He I 6678 spectral region, obtained with the Hubble Space Telescope. We show that these data are incompatible with the assumed masses of X2127+119's component stars. The continuum eclipse is too shallow, indicating that much of the accretion disc remains visible during eclipse, and therefore that the size of the donor star relative to the disc is much smaller in this high-inclination system than the assumed mass-ratio allows. Furthermore, the flux of X2127+119's He I 6678 emission, which has a velocity that implies an association with the stream-disc impact region, remains unchanged through eclipse, implying that material from the impact region is always visible. This should not be possible if the previously-assumed mass ratio is correct. In addition, we do not detect any spectral features from the donor star, which is unexpected for a 0.8 solar-mass sub-giant in a system with a 17-hour period.Comment: 6 pages, 4 figures, accepted by A&

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study.

IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in these patients. We carried out a rigorous analysis of the associations between IgG anti-apoA-1 levels and disease activity, drug therapy, serology, damage, mortality and CVD events in a large British SLE cohort

The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice

BACKGROUND: Ineffective induction of T cell mediated immunity in older individuals remains a persistent challenge for vaccine development. Thus, there is a need for more efficient and sophisticated adjuvants that will complement novel vaccine strategies for the elderly. To this end, we have investigated a previously optimized, combined molecular adjuvant, CASAC (Combined Adjuvant for Synergistic Activation of Cellular immunity), incorporating two complementary Toll-like receptor agonists, CpG and polyI:C, a class-II epitope, and interferon (IFN)-γ in aged mice. FINDINGS: In aged mice with typical features of immunosenescence, antigen specific CD8+ T cell responses were stimulated after serial vaccinations with CASAC or Complete/Incomplete Freund's Adjuvant (CFA/IFA) and a class I epitope, deriving either from ovalbumin (SIINFEKL, SIL) or the melanoma-associated self-antigen, tyrosinase-related protein-2 (SVYDFFVWL, SVL). Pentamer analysis revealed that aged, CASAC/SIL-vaccinated animals had substantially higher frequencies of H-2K(b)/SIL-specific CD8+ T cells compared to the CFA/IFA-vaccinated groups. Similarly, higher frequencies of H-2K(b)/SVL-pentamer+ and IFN-γ+ CD8+ T cells were detected in the aged, CASAC + SVL-vaccinated mice than in their CFA/IFA-vaccinated counterparts. In both antigen settings, CASAC promoted significantly better functional CD8+ T cell activity. CONCLUSION: These studies demonstrate that functional CD8+ T cells, specific for both foreign and tumour-associated self-antigens, can be effectively induced in aged immunosenescent mice using the novel multi-factorial adjuvant CASAC

Notifications for child safeguarding from an acute hospital in response to presentations to healthcare by parents.

BACKGROUND : Consideration of child safeguarding is routine within maternity services but less common in other health services for adults. We audited notifications for child safeguarding from an acute general hospital where the policy includes questioning adults presenting with violence, mental health problems or drug or alcohol misuse to any department within the hospital about children at home and notifying to the local authority children's social care services if there are safeguarding concerns. METHODS : Cross-sectional audit of notifications for child safeguarding, including abuse, neglect or victimization, from all departments in one hospital to the local authority children's social care department during 12 months (2010/11). RESULTS : Of 681 notifications (57 per month), 40% (270/681) were triggered by parents' presentation to acute hospital services. Of these, 37% (100/270; 12 teenage mothers) presented for maternity care and 60% (162/270; 8 teenage parents) presented to the emergency department (ED). Of the 60% (411/681) of notifications prompted by children presenting for healthcare, most originated from the ED (358/411; 87%): two-thirds of these presented with injury (250/358; 70%). CONCLUSION : Given a policy to ask adults about children at home, a substantial proportion of children notified for child safeguarding were recognized through presentations to acute healthcare by their parents. Further research and development of this policy needs to ensure that questioning results in effective interventions for the children and their parents

Experimental Results of Concurrent Learning Adaptive Controllers

Commonly used Proportional-Integral-Derivative based UAV flight controllers are often seen to provide adequate trajectory-tracking performance only after extensive tuning. The gains of these controllers are tuned to particular platforms, which makes transferring controllers from one UAV to other time-intensive. This paper suggests the use of adaptive controllers in speeding up the process of extracting good control performance from new UAVs. In particular, it is shown that a concurrent learning adaptive controller improves the trajectory tracking performance of a quadrotor with baseline linear controller directly imported from another quadrotors whose inertial characteristics and throttle mapping are very di fferent. Concurrent learning adaptive control uses specifi cally selected and online recorded data concurrently with instantaneous data and is capable of guaranteeing tracking error and weight error convergence without requiring persistency of excitation. Flight-test results are presented on indoor quadrotor platforms operated in MIT's RAVEN environment. These results indicate the feasibility of rapidly developing high-performance UAV controllers by using adaptive control to augment a controller transferred from another UAV with similar control assignment structure.United States. Office of Naval Research. Multidisciplinary University Research Initiative (Grant N000141110688)National Science Foundation (U.S.). Graduate Research Fellowship Program (Grant 0645960)Boeing Scientific Research Laboratorie

Approximating Fractional Time Quantum Evolution

An algorithm is presented for approximating arbitrary powers of a black box unitary operation, $\mathcal{U}^t$, where $t$ is a real number, and $\mathcal{U}$ is a black box implementing an unknown unitary. The complexity of this algorithm is calculated in terms of the number of calls to the black box, the errors in the approximation, and a certain `gap' parameter. For general $\mathcal{U}$ and large $t$, one should apply $\mathcal{U}$ a total of $\lfloor t \rfloor$ times followed by our procedure for approximating the fractional power $\mathcal{U}^{t-\lfloor t \rfloor}$. An example is also given where for large integers $t$ this method is more efficient than direct application of $t$ copies of $\mathcal{U}$. Further applications and related algorithms are also discussed.Comment: 13 pages, 2 figure