Methods and compositions for stimulating T-lymphocytes

Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes. Novel peptides are described which have been shown to stimulate cytotoxic T-lymphocytes, and act as antigens in generation of oncogenic epitope-recognizing antibodies. Methods are disclosed for use in treating various proliferative disorders, and diagnosing HER-2/neu-containing cells; also disclosed are therapeutic kits useful in the treatment of cancer and production of potential anti-cancer vaccines.Board of Regents, University of Texas Syste

State Transitions Logical Design for Hybrid Energy Generation with Renewable Energy Sources in LNG Ship

In terms of energy generation and consumption, ships are autonomous and isolated power systems with energy requirements related to the type and kind of power demands and according to ship types: passenger ships, or commercial ships. Power supply on ships is traditionally based on engines thermal generators, which use fossil fuels, diesel, or natural gas. Due to the continuous operation of thermal generators in ships, this ends up increasing polluting gas emissions for the environment, mainly CO2. A combination of Renewable Energy Sources (RES) with traditional ship thermal engines can reduce CO2 emissions, resulting in a ‘greener’ interaction between ships and the environment. Due to the varying power needs for ship operation, considering the varying nature of load demands during long distance travels and during harbor entry, the use of RES must be evaluated. This paper presents a new control method to balance LNG ship load demands and power generation from RES, based on an accurate model and solution in real conditions. The Energy Management System (EMS) is designed and implemented in a Finite State Machine structure using the logical design of state transitions. The results prove that the reduction of consumption of fossil fuels is feasible, and, if this is combined with RES, it reduces CO2 emissions