10 research outputs found
Danger of multiple use of insulin pen needles for diabetic patients
Aim. To evaluate the risk of multiple use of BD Micro-Fine Plus insulin pen needles in terms of their contamination with microflora, pain and localreaction at the injection site. Materials and methods. The study included 45 patients aged above 18 yr with type 1 and 2 diabetes mellitus (DM1 and DM2) treated with shortorultrashort-acting insulins TID. Account was taken of the time each needle was used (once, for 4 and 7 days). Microbiological analysis was madeat the respective time points. Pain sensation after injection was evaluated by patients themselves using a visual-analog scale and severity of local reactionsby the physician. Results. Microbial growth was documented in 20 and 33,3% of the patients who used needles ones or many times respectively. Patients of the lattergroup more frequently complained of pain after injection (on day 4, p=0,08) compared with those of the former one (on day 7, p=0,03). Hyperemicfoci at injection sites developed only in case of using the same needle for 4 and 7 days (13,3 and 26,6% respectively). Conclusion. Multiple use of insulin pen needles by patients with DM should be avoided since it leads to hyperemia at injection sites, pain sensation,and risk of microbial contamination
Leptin secretion and severity of glycemic disorders in women with body weight excess
Aim.
To characterize leptin secretion in fasting state and upon intravenous glucose administration in patients with type 2 diabetes mel- litus (T2DM), prediabetes and obesity.
Materials and methods.
59 female patients took part in this study: 12 had no signs of glycemic disorder, 18 were diagnosed with prediabetes and 30 ? with newly diagnosed T2DM. Median age was 54 [48.6?60] years, median BMI ? 33.2 [29.0?37.2] kg/m2. All participants were tested for fasting leptin, fasting insulin and blood glucose levels. Prediabetic and diabetic subjects also received a bolus intravenous injection of 40% glucose solution (0.75 g/kg of body mass) with subsequent additional measurement of insulin levels at 2, 70 and 120 min upon injection, and leptin levels ? at 120 min.
Results.
Median fasting leptin in obese and patients with weight excess was 42.0 [22?60] ng/mL, which is about 2 times higher than normal reference maximum (27.6 ng/mL). Subjects with prediabetes and T2DM showed significantly lower median fasting leptin levels of 29.1 ng/mL [13.5?45.7] and 21.3 [14.3?42.2], respectively (
Metformin effects to carbohydrate and lipids metabolism in impaired glucose tolerance patients.
Aim of this study was to investigate the effect metformin to carbohydrate, lipids metabolism and leptin level in impaired glucose tolerance (IGT)patients.Methods.
16 patients with IGT were studied. Age of participant was 55.1?8.2 yrs. All patients was divide into two groups: treatment group (bagomet1700 a day and diet) and control group (only diet). Effect of therapy was access in HbA1c, fasting glucose (FG), HOMA, lipids, liver glucose production(LGP) and leptin, which investigate in intravenous glucose tolerance test (IVGTT).
Results.
Normalization of carbohydrate metabolism was discover in 37.5% in treatment group and in 12.5% in control group. HbA1c was decreasefrom 6.4 to 5.9 % (
Algoritm podbora effektivnoy dozy mikronizirovannogo Maninila v nachal'noy stadii sakharnogo diabeta 2 tipa
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ
Π Π°ΠΊΡΠΈΠ²Π½ΠΎ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠΌ ΡΠ°Ρ
Π°ΡΠΎΡΠ½ΠΈΠΆΠ°ΡΡΠΈΠΌ ΡΡΠ»ΡΡΠ°Π½ΠΈΠ»Π°ΠΌΠΈΠ΄Π°ΠΌ (Π‘Π‘) ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΠ°Π½ΠΈΠ½ΠΈΠ»* (ΠΠ΅ΡΠ»ΠΈΠ½-Π₯Π΅ΠΌΠΈ, ΠΠ΅ΡΠΌΠ°Π½ΠΈΡ), Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ Π²Π΅Π΄Π΅Ρ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΠΈ Ρ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π° Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΠ°Π½ΠΈΠ½ΠΈΠ» Π½Π΅ΡΠ΅Π΄ΠΊΠΎ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΠ΅Ρ Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΡ Π² ΡΠ΅Ρ
ΡΠ»ΡΡΠ°ΡΡ
, ΠΊΠΎΠ³Π΄Π° Π΄ΡΡΠ³ΠΈΠ΅ Π‘Π‘ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΡΡ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½Ρ.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ° ΠΏΠΎΠ΄Π±ΠΎΡΠ° ΡΠ°Ρ
Π°ΡΠΎΡΠ½ΠΈΠΆΠ°ΡΡΠΈΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΠ°Π½ΠΈΠ½ΠΈΠ»ΠΎΠΌ, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΡΡΠ΅ΠΉ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΡΠΉ ΠΎΠ±ΠΌΠ΅Π½ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π½Π΅Π΄Π°Π²Π½ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π‘Π 2 ΡΠΈΠΏΠ°, ΠΏΡΠΈ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π΄ΠΈΠ΅ΡΠΎΠΉ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
ΠΠ»ΠΈΠΊΠ΅ΠΌΠΈΡ ΠΏΠ»Π°Π·ΠΌΡ Π½Π°ΡΠΎΡΠ°ΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π³Π»ΡΠΊΠΎΠ·ΠΎΠΎΠΊΡΠΈΠ΄Π°Π·Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎ ΠΈ Π² ΠΊΠΎΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π³Π»ΠΈΠΊΠ΅ΠΌΠΈΠΈ Π½Π°ΡΠΎΡΠ°ΠΊ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΠΎΡ?ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π³Π»ΡΠΊΠΎΠΌΠ΅ΡΡΠ° (One-Touch, ΡΠΈΡΠΌΡ ΠΠ°ΠΉΡ-ΡΠΊΡΠ½) 1 ΡΠ°Π· Π² 2 Π½Π΅Π΄Π΅Π»ΠΈ. ΠΠ»ΠΈΠΊΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½ ΡΡΠ°ΠΊΡΠΈΠΈ Π1Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠΎΠ½ΠΎΠΎΠ±ΠΌΠ΅Π½Π½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΠΎΠ»ΡΠ½ΡΠΌ Π½Π°Π·Π½Π°ΡΠ°Π»ΠΈ ΠΌΠΈΠΊΡΠΎΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΠ°Π½ΠΈΠ½ΠΈΠ», Π² ΠΎΠ΄Π½ΠΎΠΉ ΡΠ°Π±Π»Π΅ΡΠΊΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠΈΡΡΡ 1,75 ΠΈΠ»ΠΈ 3,5 ΠΌΠ³ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π°.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ.
Π‘Π½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ HbA1c Π² ΠΊΠΎΠ½ΡΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
: Π² 1-ΠΉ Π³ΡΡΠΏΠΏΠ΅ Π΅Π³ΠΎ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ½ΠΈΠ·ΠΈΠ»ΡΡ Π½Π° 2 % ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΈΡΡ
ΠΎΠ΄Π½ΡΠΌ, Π²ΠΎ 2-ΠΉ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π±ΡΠ»ΠΎ Π±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΌ. Π ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° Π½ΠΈΠ·ΠΊΠ°Ρ ΡΠ°ΡΡΠΎΡΠ° Π³ΠΈΠΏΠΎΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ. ΠΠΠ’ Π½Π΅ ΡΠ²Π΅Π»ΠΈΡΠΈΠ»ΡΡ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
. ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΠΎΠ±ΡΠ΅Π³ΠΎ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π·Π° ΡΡΠ΅Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ ΠΈ ΡΡΠΎΠ²Π½Ρ ΡΡΠΈΠ³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ².
ΠΡΠ²ΠΎΠ΄Ρ
ΠΠΈΠΊΡΠΎΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΠ°Π½ΠΈΠ½ΠΈΠ» ΠΌΠΎΠΆΠ΅Ρ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΊΠ°ΠΊ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ Π²ΡΠ±ΠΎΡΠ° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π 2 ΡΠΈΠΏΠ° ΠΏΡΠΈ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π΄ΠΈΠ΅ΡΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π΅Π³ΠΎ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ»ΡΡΡΠ°Π΅Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΏΡΠΈ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΠ°ΡΡΠΎΡΠ΅ Π³ΠΈΠΏΠΎΠ³Π»ΠΈΠΊΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ. ΠΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΡ ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Ρ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π° Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π½Π΅Π΄Π°Π²Π½ΠΎ Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠΌ Π‘Π 2 ΡΠΈΠΏΠ° ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΠ° Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΈΠ΅ΠΌΠ° Π΄ΠΎΠ· ΠΌΠΈΠΊΡΠΎΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΠ°Π½ΠΈΠ½ΠΈΠ»Π°, Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠΈΡ
ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Ρ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ
Initial glucose-lowering therapy and risks of overall and cardiovascular mortality, myocardial infarction and stroke in patients with type2 diabetes
Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΈΡΡ ΡΠΈΡΠΊΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΠ±ΡΠ΅ΠΉ ΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΈΡΠΊΠΈ ΡΠ°ΡΠ°Π»ΡΠ½ΡΡ
ΠΈ Π½Π΅ΡΠ°ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΠ½ΡΠ°ΡΠΊΡΠΎΠ² ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° (ΠΠ) ΠΈ ΠΎΡΡΡΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΠΌΠΎΠ·Π³ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ (ΠΠΠΠ) Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ 2 ΡΠΈΠΏΠ° (Π‘Π2) Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΈΠ΄Π° ΠΏΠ΅ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°Ρ
Π°ΡΠΎΡΠ½ΠΈΠΆΠ°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (ΠΠ‘Π‘Π), Π½Π°Π·Π½Π°ΡΠ΅Π½Π½ΠΎΠΉ ΠΏΠΎΡΠ»Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π΄ΠΈΠ°Π±Π΅ΡΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΡΠΊΡΡΡΠΎΠ³ΠΎ ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΏΡΡΠΈΠ»Π΅ΡΠ½Π΅Π³ΠΎ ΡΠΈΡΠΊΠ° ΠΎΠ±ΡΠ΅ΠΉ ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΠ ΠΈ ΠΠΠΠ Ρ Π»ΠΈΡ, Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ
Π‘Π2 Π² 2004 Π³ΠΎΠ΄Ρ ΠΈ ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
ΡΠ΅ΡΠ°ΠΏΠΈΡ ΡΠ°Π·- Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΠ‘Π‘Π. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΈΡΠΊΠΎΠ² ΡΠΌΠ΅ΡΡΠΈ ΠΎΡ Π»ΡΠ±ΡΡ
ΠΏΡΠΈΡΠΈΠ½, ΡΠΌΠ΅ΡΡΠΈ ΠΎΡ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΠ ΠΈ ΠΠΠΠ Π±ΡΠ» ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Cox-ΡΠ΅Π³ΡΠ΅ΡΡΠΈΠΎΠ½Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΠΎΡΠ»Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ?Π‘Π2? Π±ΡΠ»ΠΈ Π½Π°Π·Π½Π°ΡΠ΅Π½Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΡΡΠ»ΡΡΠΎΠ½ΠΈΠ»ΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ (Π‘Π), ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΌΠ΅ΡΡΠΎΡΠΌΠΈΠ½Π° ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠΊΠ° ΠΎΠ±ΡΠ΅ΠΉ ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Π² Π΄Π²Π° ΡΠ°Π·Π° (
Significance of HbA1c targets based on an individual approach to the treatment of patients with type 2 diabetes mellitus
Background.
Over the past few years, special attention has been paid to achieving glycaemic control for type 2 diabetes mellitus (T2DM) patients, since it is a factor for determining the risk of developing macro- and microvascular complications of diabetes. Certain modern guidelines suggest an individual approach to the choice of HbA1cΒ target.
Objective.
Objective.
Β .
of this study was to estimate the percentage of T2DM patients who have reached the HbA1cΒ levels. This was determined based on their age and the presence of severe complications.
Materials and Methods.
A total of 2195 patients with T2DM were studied. The patients were divided into the following age groups
Incidence of sleep apnea in patients with various types of glycemic disturbances
Aims. To assess the risk for sleep apnea in patients with various types of glycemic disorders by means of Epworth Sleepiness Scale andSleep Apnea Screening Questionnaire. Materials and Methods. We examined 744 residents of Mozhaisk Region, that were considered to have high risk for development of type2 diabetes mellitus (T2DM), as estimated by FINDRISK Questionnaire. Patients, who scored 12+ were cleared for participation in this study. Combined score from Epworth Sleepiness Scale and Sleep Apnea Screening Questionnaire was applied for diagnosis of sleep apnea, supplemented with specific questions about snoring and episodes of apnea. Glycemic disorders were diagnosed with standard glucose tolerance test. Results. 42.7% of examined patients (n=318) were diagnosed with various types of glucose disorders. Prevalence of abdominal obe- sity (according to waist circumference measurement) comprised 59.3% in male patients and 54.1% in females. We observed positive correlation between body mass index (BMI) and snoring ? 0.3 (p=0.0001), BMI and apnea ? 0.2 (p=0.0001), BMI and daytime sleepiness ? 0.1 (p=0.007); we also observed direct correlation between age and snoring ? 0.2 (p=0.0001), as well as age and sleep apnea ? 0.1 (p=0.028). Risk for sleep apnea was found to be 4.7 times higher in patients with arterial hypertension. After adjustment71ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°, ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅Π‘Π°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ. 2013;(1):71?77Π‘Π°Ρ
Π°Ρ Π½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρfor age risk of apnea remained 2.8 times higher in patients with T2DM, 1.9 times higher in subjects with impaired glucose tolerance and1.6 times higher in subjects with impaired fasting glycaemia. Relative risk for snoring in patients with various types of glycemic disorders was 1.1-1.2 against normoglycemic controls. We estimated that all types of glycemic disorders increase risk for apnea 1.2?1.6 times. Conclusion. Glycemic disorders, body weight excess, obesity and arterial hypertension are risk factors for snoring and sleep apnea. Corresponding patient categories should be screened for sleep apnea by questionnaire survey to identify those in need of further complex examination and treatment
Optimizing screening procedures for early detection of glycemic disorders
Aim.
To estimate the actual prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in individuals at high risk for T2DM and to develop an optimized stepwise screening procedure.
Materials and Methods.
A mobile diagnostic unit conducted outpatient screening for glycemic disorders. First stage of the survey included distribution of the FINDRISK questionnaire within the target subpopulation. At the second stage, study groups were formed based on the acquired data. Third stage involved clinical evaluation of glucose homeostasis by testing HbA1c levels and performing oral glucose tolerance test (OGTT). Individuals considered at high risk for development of T2DM were referred to specialized educational programs. A total of 2200 subjects were included in the present survey. In 1377 cases OGTT was supplemented with the testing of HbA1c. Statistical processing of the data was performed with Microsoft Excel software utility.
Results.
The interpretation of OGTT results identified 53.5% (n=1176) of study subjects as positive for glycemic disorders: 26.7% (n=587) with T2DM and 26.8% (n=589) with prediabetes, respectively. Impaired glucose tolerance was detected in 12.1% (n=266), impaired fasting glucose ? in 9.1% (n=199), and the combination of these two conditions ? in 5.6% (n=124) of examined individuals, respectively. In 235 subjects (17.1%) T2DM was diagnosed by means of HbA1c testing. 45% of examined individuals (n=620) had HbA1